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    v1.0.30
    OpenPayerBilling CodesBypass Graft Procedures Other Than VeinCPT cpt-35621-axillofemoral-bypass-synthetic-graft
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    CPT 35621: Axillary–Femoral Bypass with Synthetic Graft

    Medicare pays $990 on average nationally for this procedure.

    CPT code 35621 describes a surgical axillary–femoral bypass using a synthetic graft to bypass obstruction of the lower aorta or iliac artery; the service is a vascular bypass procedure typically performed in an operating room or surgical suite (inpatient or outpatient surgical setting) to restore lower extremity blood flow by connecting the axillary artery to the femoral artery.

    For related coverage guidance, see recent payer policy updates: Surgical Procedures, Outpatient Surgical Procedures - Site of Service, Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 72-year-old male with progressive claudication, rest pain in the lower extremities, and imaging-confirmed severe aortoiliac occlusive disease (chronically occluded infrarenal aorta and bilateral common iliac arteries) is scheduled for revascularization. The vascular surgery team plans an extra-anatomic axillofemoral bypass using a synthetic graft to restore perfusion to the lower extremity by connecting the axillary artery to the femoral artery (CPT 35621). Preoperative workup includes arterial duplex ultrasound and CT angiography, cardiopulmonary risk assessment, and informed consent discussing limb salvage and graft patency expectations. The procedure is performed in an operating room under general or regional anesthesia with vascular surgery or cardiothoracic-vessel trained surgeons and perioperative vascular access and monitoring. Postoperative care includes anticoagulation management, wound and graft surveillance, and vascular imaging follow-up to assess patency and limb perfusion.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36147Arterial catheterization or cannulation for diagnostic or therapeutic injection, percutaneous, femoral, brachial or axillary, including diagnostic angiography when performedCommonly performed preoperatively or intraoperatively for angiographic assessment or distal run-off evaluation prior to CPT 35621

    | 35566 | Thromboendarterectomy, iliac artery, with or without patch graft | Performed in alternative open aortoiliac reconstructions; may be performed in same patient if focal lesions are amenable to endarterectomy rather than extra-anatomic bypass |

    | 35102 | Graft, bypass, or bypass graft, femoral-femoral bypass, prosthetic graft | Femoral-femoral bypass is an alternative extra-anatomic revascularization; may be considered in similar clinical workflows or performed sequentially in staged procedures |

    | 36818 | Introduction of tunneled intravascular catheter, dialysis or long term | May be billed when long-term vascular access is needed in complex vascular patients (contextual ancillary service) |

    | 93975 | Duplex scan of extremity arteries, bilateral study | Noninvasive testing used preoperatively and postoperatively to assess arterial disease and graft patency |

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208800000X
    207L00000X
    207T00000X
    2081P2900X
    103TP2701X
    261Q00000X
    2083X0100X
    2080S0010X

    Related Payer Policy Updates

    Specialty: General Surgery1 / 2

    10 rows

    PolicyPayerEffective Date
    Surgical ProceduresUnitedHealthcare2026-09-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01

    Related Codes

    CPT-35600-ARTERIAL-GRAFT-HARVEST-ARM-FOR-CORONARY-BYPASS

    CPT 35600: Arm Artery Harvest for Coronary Bypass

    CPT-35601-CAROTID-COMMON-ARTERY-BYPASS-SYNTHETIC-GRAFT

    CPT 35601: Common Carotid Artery Bypass with Synthetic Graft

    CPT-35602-CAROTID-TO-CAROTID-PROSTHETIC-ARTERIAL-BYPASS

    CPT 35602: Carotid-to-Carotid Bypass with Prosthetic Graft

    CPT-35606-SUBCLAVIAN-ARTERY-BYPASS-SYNTHETIC-GRAFT

    CPT 35606: Subclavian Artery Bypass with Synthetic Graft

    CPT-35612-SUBCLAVIAN-ARTERY-BYPASS-SYNTHETIC-GRAFT

    CPT 35612: Subclavian Artery Bypass with Synthetic Graft

    CPT-35616-SUBCLAVIAN-TO-AXILLARY-BYPASS-SYNTHETIC-GRAFT

    CPT 35616: Subclavian to Axillary Bypass with Synthetic Graft

    CPT-35623-AXILLARY-TO-POPLITEAL-OR-TIBIAL-BYPASS-SYNTHETIC-GRAFT

    CPT 35623: Axillofemoral to Popliteal/Tibial Bypass with Synthetic Graft

    CPT-35626-AORTIC-TO-SUBCLAVIAN-INNOMINATE-CAROTID-BYPASS-GRAFT

    CPT 35626: Aortic-to-Subclavian/Innominate/Carotid Bypass with Synthetic Graft

    CPT-35631-AORTO-VISCERAL-RENAL-BYPASS-SYNTHETIC-GRAFT

    CPT 35631: Aorto-Visceral Bypass with Synthetic Graft

    CPT-35632-ILIAC-TO-CELIAC-SYNTHETIC-GRAFT-BYPASS

    CPT 35632: Iliac-to-Celiac Arterial Bypass with Synthetic Graft

    Showing 1–10 of 27

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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