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    OpenPayerBilling CodesVenous Embolectomy/Thrombectomy, Direct or With CatheterCPT cpt-34421-thrombectomy-vena-cava-iliac-femoropopliteal
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    CPT 34421: Thrombectomy of Vena Cava/Iliac/Femoropopliteal Vein

    Medicare pays $635 on average nationally for this procedure.

    CPT code 34421 describes a surgical thrombectomy involving an incision in the leg to remove thrombus from the vena cava, iliac, and/or femoropopliteal vein, performed with or without catheter assistance; service type: open surgical venous thrombectomy; typical site of service: operating room or surgical suite, often in a hospital inpatient or outpatient surgical setting.

    For related coverage guidance, see recent payer policy updates: Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policy, Emergency Air/Water Ambulance Services Medical Guideline, Non-Emergent Ambulance Services.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a middle-aged adult presenting with acute or subacute lower-extremity venous thrombosis extending into the femoropopliteal, iliac, or inferior vena cava segments causing limb-threatening ischemia, severe swelling, or significant thrombus burden despite anticoagulation. The patient often has risk factors such as recent immobility, malignancy, recent surgery, or a hypercoagulable state. Initial evaluation includes duplex ultrasonography and cross-sectional venography (CT or MR venography) to define thrombus extent. Anticoagulation is started unless contraindicated. When percutaneous catheter-directed techniques are insufficient or thrombus burden/anatomy requires open exposure, the vascular surgeon performs a surgical thrombectomy via an incision in the leg to access femoral or popliteal veins and remove clot material; this may be combined with intraoperative venography, catheter thrombectomy, or caval/iliac exploration. Postoperative care includes anticoagulation management, limb monitoring, and imaging follow-up to confirm patency and detect residual thrombus or complications such as bleeding or recurrent thrombosis.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36010Introduction of catheter, inferior vena cava, by percutaneous translumbar or transjugular approach, with or without radiological supervision and interpretationMay be used for venous access or venography of the IVC when planning or during thrombectomy; commonly performed in hybrid cases
    37211Endovascular mechanical thrombectomy, percutaneous, for acute thrombus removal, peripheral arterial or venous, including aspiration thrombectomy when performedUsed when adjunctive percutaneous catheter-directed mechanical thrombectomy is performed in conjunction with surgical thrombectomy
    36901Open treatment of central venous occlusion (e.g., venous thrombectomy of major central veins)May be reported for open central venous procedures involving iliac or caval thrombectomy components alongside 34421
    37184Thrombolysis, infusion for thrombolytic agent, including angiographic monitoring, infusion catheter placementUsed when catheter-directed thrombolysis is employed pre- or post-thrombectomy to dissolve residual thrombus
    36478Thrombolysis, percutaneous mechanical, for upper or lower extremity venous thrombosis (catheter-directed), including infusion and mechanical componentsReported when percutaneous catheter-directed thrombolysis/thrombectomy is done as part of a combined approach
    36415Collection of venous blood by venipunctureRoutine preoperative lab draw; ancillary to surgical care

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    207RG0300X
    207K00000X
    207L00000X
    106H00000X
    2255A2300X
    156FC0800X
    225XG0600X

    Related Payer Policy Updates

    Specialty: Emergency & Medical Transportation1 / 3

    10 rows

    PolicyPayerEffective Date
    Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policybcbsvermont2026-10-01
    Emergency Air/Water Ambulance Services Medical GuidelineWPS Health Insurance2026-10-01
    Non-Emergent Ambulance ServicesConnectiCare2026-09-11
    Fixed Wing Air Ambulance TransportCigna2026-08-15
    Air AmbulanceAmbetter Georgia2026-08-01
    Ambulance Services (for New Mexico Only)UnitedHealthcare2026-08-01
    Ambulance Services (for Tennessee Only)UnitedHealthcare2026-08-01
    Clinical Policy: Air AmbulanceAmbetter Nevada2026-08-01
    Air AmbulanceCentene2026-08-01
    Clinical Policy: Air AmbulanceArizona Complete Health2026-08-01

    Related Codes

    CPT-34401-OPEN-VENOUS-THROMBECTOMY-VENA-CAVA-ILIAC-VEIN-REPAIR

    CPT 34401: Thromboembolectomy, Vena Cava or Iliac Vein, Open Abdominal Approach

    CPT-34451-SURGICAL-VENOUS-THROMBECTOMY-OPEN-THROMBECTOMY

    CPT 34451: Open Thrombectomy of Vena Cava/Iliac/Femoropopliteal Vein

    CPT-34471-SUBCLAVIAN-VEIN-THROMBECTOMY-OPEN-REMOVAL-CLOT

    CPT 34471: Subclavian Vein Thrombectomy via Neck Incision

    CPT-34490-UPPER-EXTREMITY-VENOUS-THROMBECTOMY-SUBCLAVIAN-AXILLARY

    CPT 34490: Upper-Extremity Thrombectomy, Subclavian/Axillary Vein

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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