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    v1.0.28
    OpenPayerBilling CodesRepair, Revision, and/or Reconstruction Procedures on the Femur (Thigh Region) and Knee JointCPT cpt-27416-osteochondral-autograft-transfer-mosaicplasty
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    CPT 27416: Osteochondral Autograft Transfer (Mosaicplasty)

    Medicare pays $917 on average nationally for this procedure.

    CPT code 27416 describes an osteochondral autograft transfer (mosaicplasty) procedure in which the surgeon harvests small cylindrical bone-cartilage grafts from a non–weight-bearing area of the joint (commonly the femoral condyles) and transplants them to focal articular cartilage defects to repair damaged cartilage; service type: surgical cartilage restoration; typical site of service: operating room, orthopaedic surgical setting (knee joint, non–weight-bearing donor sites such as femoral condyles).

    For related coverage guidance, see recent payer policy updates: Shoulder Arthroplasty (Total, Partial, Reverse, Revision and Resurfacing), Hip Arthroplasty (partial and total hip replacement), Artificial Lumbar Intervertebral Disc (Lumbar Total Disc Arthroplasty).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 28-year-old physically active patient presents with persistent focal full-thickness articular cartilage defect of the medial femoral condyle after a history of twisting knee injury and failed conservative care. Imaging with MRI demonstrates a 2.2 cm2 osteochondral lesion with preserved surrounding bone and no advanced osteoarthritis. The orthopedic surgeon schedules an arthrotomy or arthroscopic-assisted procedure for autologous osteochondral grafting (mosaicplasty) using small cylindrical osteochondral plugs harvested from a non–weight bearing area of the femoral condyle and transplanted into the defect.

    Preoperative workflow includes clinical evaluation, informed consent, pre-op imaging review, and anesthesia assessment. Intraoperative steps include diagnostic arthroscopy, preparation of the recipient site, harvesting osteochondral plugs from non–weight bearing femoral condyle, placement and press-fit fixation of grafts to restore articular surface congruity, hemostasis, and wound closure. Postoperative workflow includes recovery room monitoring, pain control, immobilization or brace, graduated weight-bearing restrictions, and physical therapy for joint mobilization and strengthening. Typical site of service is an outpatient ambulatory surgery center or hospital outpatient department with regional or general anesthesia.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    29881Arthroscopy, knee, surgical; synovectomy, limitedMay be performed prior to or during cartilage restoration to address synovitis or evaluate the joint arthroscopically.
    27599Unlisted procedure, femur and kneeSometimes used if a component of osteochondral grafting is atypical and no specific CPT exists for a particular adjunct procedure.
    27332Osteotomy, femoral, for correction of deformityPerformed in staged or concurrent cases when alignment correction is required for durable cartilage repair.
    20610Arthrocentesis, aspiration and/or injection; major joint or bursaMay be used pre- or postoperatively for diagnostic aspiration or therapeutic injections.
    29877Arthroscopy, knee, debridement/shaving of articular cartilage (chondroplasty)May be performed arthroscopically as an adjunct to prepare the recipient site or treat other focal lesions.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207X00000XOrthopaedic Surgery PhysicianAn orthopaedic surgeon is trained in the preservation, investigation and restoration of the form and function of the extremities, spine and associated…
    2080P0208XPediatric Infectious Diseases PhysicianA pediatrician trained to care for children in the diagnosis, treatment and prevention of infectious diseases. This specialist can apply specific know…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    2472D0500XDarkroom TechnicianNone
    163WX0601XOtorhinolaryngology & Head-Neck Registered NurseNursing Service Providers · Registered Nurse
    2471S1302XSonography Radiologic TechnologistA radiologic technologist who specializes in sonography and is appropriately educated and trained, consistent with nationally recognized standards, st…
    224L00000XPedorthistAn individual who is trained in the management and treatment of conditions of the foot, ankle, and lower extremities requiring fitting, fabricating, a…

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    M16.11Unilateral primary osteoarthritis, right hip
    M16.12Unilateral primary osteoarthritis, left hip
    M17.0Bilateral primary osteoarthritis of knee
    M17.11Unilateral primary osteoarthritis, right knee
    M17.12Unilateral primary osteoarthritis, left knee
    M17.5Other unilateral secondary osteoarthritis of knee
    M17.9Osteoarthritis of knee, unspecified
    M22.2X1Patellofemoral disorders, right knee
    M22.2X2Patellofemoral disorders, left knee
    M23.201Derangement of unspecified lateral meniscus due to old tear or injury, left knee

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: Orthopedics/Musculoskeletal1 / 3

    10 rows

    PolicyPayerEffective Date
    Shoulder Arthroplasty (Total, Partial, Reverse, Revision and Resurfacing)univerahealthcare2026-10-15
    Hip Arthroplasty (partial and total hip replacement)univerahealthcare2026-10-15
    Artificial Lumbar Intervertebral Disc (Lumbar Total Disc Arthroplasty)univerahealthcare2026-10-15
    Osteochondral Grafting of the Kneeuniverahealthcare2026-10-15
    Metal-on-Metal Total Hip Resurfacinguniverahealthcare2026-10-15
    Lumbar Fusion (arthrodesis) with decompressionuniverahealthcare2026-10-15
    Sacroiliac Joint Fusion or Stabilizationuniverahealthcare2026-10-15
    Percutaneous Vertebroplasty/Mechanical Vertebral Augmentation and Percutaneous Sacroplastyuniverahealthcare2026-10-15
    Autologous Chondrocyte Implantation (ACI)univerahealthcare2026-10-15
    Shoulder Open ProceduresPremera Bluecross2026-09-04

    Related Codes

    CPT-27380-INFRAPATELLAR-TENDON-PRIMARY-REPAIR

    CPT 27380: Primary Repair of Infrapatellar (Patellar) Tendon

    CPT-27381-SECONDARY-INFRAPATELLAR-TENDON-REPAIR

    CPT 27381: Secondary Repair of Infrapatellar Tendon

    CPT-27385-HAMSTRING-QUADRICEPS-RUPTURE-REPAIR-SUTURE

    CPT 27385: Primary Repair of Hamstring or Quadriceps Rupture

    CPT-27386-SECONDARY-QUADRICEPS-HAMSTRING-REPAIR-AUTOGRAFT

    CPT 27386: Secondary Repair of Quadriceps or Hamstring with Graft

    CPT-27390-OPEN-TENOTOMY-HAMSTRING-SINGLE-TENDON

    CPT 27390: Open Tenotomy of Hamstring Tendon

    CPT-27391-OPEN-HAMSTRING-TENOTOMY

    CPT 27391: Open Tenotomy of Multiple Hamstring Tendons

    CPT-27392-OPEN-TENOTOMY-HAMSTRING-BILATERAL

    CPT 27392: Open Bilateral Hamstring Tenotomy

    CPT-27393-HAMSTRING-TENDON-LENGTHENING

    CPT 27393: Hamstring Tendon Lengthening

    CPT-27394-HAMSTRING-TENDON-LENGTHENING-UNILATERAL

    CPT 27394: Hamstring Tendon Lengthening, Unilateral

    CPT-27395-HAMSTRING-TENDON-LENGTHENING-BILATERAL

    CPT 27395: Bilateral Hamstring Tendon Lengthening

    Showing 1–10 of 59

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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