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    v1.0.28
    OpenPayerBilling CodesRepair, Revision, and/or Reconstruction Procedures on the Forearm and WristCPT cpt-25449-wrist-prosthesis-revision-removal-replacement
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    CPT 25449: Removal or Replacement of Wrist Prosthesis

    Medicare pays $949 on average nationally for this procedure.

    CPT code 25449 describes surgical reopening of a previously reconstructed wrist joint to remove or replace an artificial prosthesis of the distal radius and metacarpal articulation; service type: surgical prosthesis removal/revision; typical site of service: inpatient or outpatient operating room or ambulatory surgery center for orthopedic hand/wrist surgery where management of infection or prosthesis loosening is required.

    For related coverage guidance, see recent payer policy updates: Hip Arthroplasty (partial and total hip replacement), Shoulder Arthroplasty (Total, Partial, Reverse, Revision and Resurfacing), Artificial Lumbar Intervertebral Disc (Lumbar Total Disc Arthroplasty).

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    Table of contents

    Progress1 / 7

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    • Billing CodesCPT, HCPCS, DRG & more
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    • ModifiersCPT modifiers & usage
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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old patient with a history of wrist arthroplasty presents with progressive wrist pain, swelling, erythema, and decreased range of motion several months after implantation of a distal radius-to-carpal joint prosthesis. Imaging demonstrates peri-prosthetic lucency and component loosening; aspiration yields purulent fluid positive for bacteria. The orthopedic hand surgeon schedules a revision/removal of the wrist prosthesis under general anesthesia. The clinical workflow includes preoperative evaluation and optimization, informed consent addressing risks of infection and instability, perioperative administration of prophylactic or targeted antibiotics, reopening the prior incision, explantation of the radial and/or carpal prosthetic components, irrigation and debridement of infected or necrotic tissue, intraoperative cultures, possible placement of an antibiotic spacer or new prosthesis if indicated, closure with drains as needed, and postoperative wound care with tailored antibiotic therapy and hand therapy referral for rehabilitation. Typical inpatient or ambulatory surgical center resources include anesthesia, intraoperative imaging, microbiology, and orthopedic hand/upper-extremity surgical teams. Ancillary care may include infectious disease consultation for prosthetic joint infection management and coordination with rehabilitation services for recovery planning.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    20610Arthrocentesis, aspiration and/or injection; major joint or bursa (e.g., shoulder, hip, knee), without ultrasound guidancePreoperative diagnostic aspiration of wrist effusion or for culture to evaluate suspected prosthetic infection.
    11042Debridement; skin, subcutaneous tissue and muscle, first 20 sq cm or lessAdjunct debridement of infected soft tissue at the time of prosthesis removal when extensive soft-tissue excision is required.
    23120Arthrotomy, wrist; with exploration, drainage or removal of foreign body or prosthetic deviceAlternative upper-extremity code describing removal of prosthetic material or drainage; may be used as adjunct or for coding related procedures.
    20690Drainage of hematoma, seroma or fluid collection; complicated (e.g., requiring incision)Management of postoperative or intraoperative fluid collections encountered during explantation.
    24361Revision total knee arthroplasty (not wrist; placeholder)Data not available in the input.
    64450Injection, anesthetic agent; other peripheral nerve or branch (eg, ilioinguinal, iliohypogastric)Regional nerve block for perioperative analgesia of the wrist/hand during or after 25449.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207X00000XOrthopaedic Surgery PhysicianAn orthopaedic surgeon is trained in the preservation, investigation and restoration of the form and function of the extremities, spine and associated…
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    364SC0200XCritical Care Medicine Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    364SR0400XRehabilitation Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    207ZC0008XClinical Informatics (Pathology) PhysicianPhysicians who practice Clinical Informatics collaborate with other health care and information technology professionals to analyze, design, implement…
    225XN1300XNeurorehabilitation Occupational TherapistRespiratory, Developmental, Rehabilitative and Restorative Service Providers · Occupational Therapist

    Related ICD-10-CM Codes

    18 rows

    ICD-10-CM CodeDescription
    M00.241Other streptococcal arthritis, right hand
    M00.242Other streptococcal arthritis, left hand
    M00.249Other streptococcal arthritis, unspecified hand
    M02.231Postimmunization arthropathy, right wrist
    M02.232Postimmunization arthropathy, left wrist
    M02.239Postimmunization arthropathy, unspecified wrist
    M05.831Other rheumatoid arthritis with rheumatoid factor of right wrist
    M06.831Other specified rheumatoid arthritis, right wrist
    M17.0Bilateral primary osteoarthritis of knee
    M19.041Primary osteoarthritis, right hand

    Showing 1–10 of 18

    Related Payer Policy Updates

    Specialty: Orthopedics/Musculoskeletal1 / 2

    6 rows

    PolicyPayerEffective Date
    Hip Arthroplasty (partial and total hip replacement)univerahealthcare2026-10-15
    Shoulder Arthroplasty (Total, Partial, Reverse, Revision and Resurfacing)univerahealthcare2026-10-15
    Artificial Lumbar Intervertebral Disc (Lumbar Total Disc Arthroplasty)univerahealthcare2026-10-15
    Osteochondral Grafting of the Kneeuniverahealthcare2026-10-15
    Lumbar Fusion (arthrodesis) with decompressionuniverahealthcare2026-10-15
    Metal-on-Metal Total Hip Resurfacinguniverahealthcare2026-10-15

    Related Codes

    CPT-25260-FLEXOR-TENDON-REPAIR-FOREARM-WRIST-ACUTE

    CPT 25260: Flexor Tendon or Muscle Repair, Forearm or Wrist

    CPT-25263-DELAYED-FLEXOR-TENDON-REPAIR-FOREARM-WRIST

    CPT 25263: Delayed Repair of Flexor Tendon or Muscle, Forearm/Wrist

    CPT-25265-FLEXOR-TENDON-MUSCLE-REPAIR-WITH-AUTOLOGOUS-GRAFT-DELAY

    CPT 25265: Flexor Tendon/Muscle Repair with Autograft, Forearm or Wrist

    CPT-25270-EXTENSOR-TENDON-REPAIR-FOREARM-WRIST-ACUTE

    CPT 25270: Extensor Tendon Repair, Forearm or Wrist

    CPT-25272-DELAYED-EXTENSOR-TENDON-REPAIR-FOREARM-WRIST

    CPT 25272: Delayed Repair of Extensor Tendon or Muscle, Forearm/Wrist

    CPT-25274-DELAYED-EXTENSOR-TENDON-REPAIR-WITH-AUTOLOGOUS-GRAFT

    CPT 25274: Extensor Tendon/Muscle Repair with Autologous Graft

    CPT-25275-EXTENSOR-TENDON-REPAIR-WRIST-FOREARM-GRAFT

    CPT 25275: Extensor Tendon Repair of Forearm/Wrist with Graft

    CPT-25280-FOREARM-WRIST-TENDON-LENGTH-ADJUSTMENT-REPAIR

    CPT 25280: Tendon Shortening/Adjustment in Forearm or Wrist

    CPT-25290-FLEXOR-TENDON-RELEASE-FOREARM-WRIST-OPEN

    CPT 25290: Open Flexor Tendon Release, Forearm or Wrist

    CPT-25295-TENDON-ADHESION-RELEASE-FOREARM-WRIST

    CPT 25295: Tendon Adhesion Release, Forearm or Wrist

    Showing 1–10 of 53

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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