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    v1.0.28
    OpenPayerBilling CodesExcision Procedures on the HeadCPT cpt-21040-mandible-benign-tumor-enucleation-curettage
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    CPT 21040: Enucleation or Curettage of Mandible, Benign Lesion

    Medicare pays $496 on average nationally for this procedure.

    CPT code 21040 describes surgical removal of a benign mandibular tumor by enucleation and/or curettage, a procedure that involves removing the lesion intact or scraping diseased tissue from the mandible; the service is a minor oral/maxillofacial surgical procedure typically performed in an ambulatory surgical center, hospital outpatient department, or oral surgery clinic under local or general anesthesia.

    For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, Hearing Services - General, Cochlear Implants.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 42-year-old patient presents to an oral and maxillofacial surgery clinic with progressive swelling and localized pain in the posterior mandible. Imaging (panoramic radiograph and CT) demonstrates a radiolucent lesion consistent with a benign odontogenic cystic tumor such as an odontogenic keratocyst or ameloblastoma confined to the mandible. After preoperative evaluation and informed consent, the patient is scheduled for enucleation and curettage of the benign mandibular tumor under general anesthesia. The clinical workflow includes preoperative imaging and labs, anesthesia evaluation, intraoperative removal of the lesion by enucleation and curettage with hemostasis and irrigation, specimen submission for pathology, postoperative monitoring in PACU, and discharge with wound care and outpatient follow-up for radiographic surveillance and potential reconstruction if needed.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    21045Excision of benign tumor or cyst of mandible requiring partial ostectomy, with or without local flapUsed when lesion removal requires partial ostectomy rather than simple enucleation/curettage; may be an alternative or follow-up if more bone removal is needed.
    40820Removal of lesion of oral soft tissue (except tonsillectomy and adenoidectomy) — single lesionPerformed when soft tissue extension of the mandibular lesion requires excision of adjacent intraoral soft tissue.
    40490Biopsy of oral mucosa, single lesionDiagnostic biopsy code used preoperatively or intraoperatively when tissue sampling precedes definitive enucleation.
    88305Level IV surgical pathology, gross and microscopic examinationUsed for pathology processing of the resected specimen to establish definitive histologic diagnosis.
    41899Unlisted procedure, dentoalveolar structuresUsed when a specific dentoalveolar procedure related to the mandible is performed that has no direct CPT match.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    208600000XSurgery PhysicianA general surgeon has expertise related to the diagnosis - preoperative, operative and postoperative management - and management of complications of s…
    332H00000XEyewear SupplierAn organization that provides spectacles, contact lenses, and other vision enhancement devices prescribed by an optometrist or ophthalmologist.
    2080P0208XPediatric Infectious Diseases PhysicianA pediatrician trained to care for children in the diagnosis, treatment and prevention of infectious diseases. This specialist can apply specific know…
    3336H0001XHome Infusion Therapy PharmacyPharmacy-based, decentralized patient care organization with expertise in USP 797-compliant sterile drug compounding that provides care to patients wi…
    2080P0214XPediatric Pulmonology PhysicianA pediatrician dedicated to the prevention and treatment of all respiratory diseases affecting infants, children and young adults. This specialist is …
    2083P0901XPublic Health & General Preventive Medicine PhysicianPublic health and general preventive medicine focuses on promoting health, preventing disease, and managing the health of communities and defined popu…

    Related Payer Policy Updates

    Specialty: Otorhinolaryngology (ENT)1 / 2

    10 rows

    PolicyPayerEffective Date
    Oral Cancer Screening and TestingOscar Health2026-10-01
    Hearing Services - GeneralAlabama Medicaid2026-09-14
    Cochlear ImplantsBlue Cross Blue Shield - Rhode Island2026-09-01
    Balloon Dilation of the Eustachian TubeBlue Cross Blue Shield - Rhode Island2026-09-01
    Treatment of Nasal Valve Collapse and Nasal Septal Swell BodiesBluecross Idaho2026-08-01
    Sinus Surgeries and Interventions (for New Mexico Only)UnitedHealthcare2026-08-01
    Sinus Surgeries and Interventions (for Kansas Only)UnitedHealthcare2026-08-01
    Hearing Aids and Auditory ImplantsUnitedHealthcare2026-08-01
    Repair of Nasal Valve CompromiseAmbetter Georgia2026-08-01
    Surgical Treatment of Snoring and Obstructive Sleep (OSA)Premera Bluecross2026-08-01

    Related Codes

    CPT-21011-FACE-SCALP-SOFT-TISSUE-TUMOR-EXCISION-LESS-THAN-2CM

    CPT 21011: Excision of Small Subcutaneous Soft Tissue Tumor, Face/Scalp

    CPT-21012-SOFT-TISSUE-TUMOR-EXCISION-FACE-SCALP

    CPT 21012: Excision of Soft Tissue Tumor, Face or Scalp

    CPT-21013-SOFT-TISSUE-TUMOR-EXCISION-FACE-SCALP

    CPT 21013: Excision of Soft Tissue Tumor, Face or Scalp

    CPT-21014-SOFT-TISSUE-TUMOR-EXCISION-FACE-SCALP

    CPT 21014: Excision of Soft Tissue Tumor of Face or Scalp

    CPT-21015-RADICAL-EXCISION-FACE-SCALP-TUMOR

    CPT 21015: Radical Excision of Tumor from Face or Scalp

    CPT-21016-EXTENSIVE-EXCISION-SOFT-TISSUE-TUMOR-FACE-SCALP

    CPT 21016: Excision of Soft Tissue Malignant Tumor, Face/Scalp, ≥2 cm

    CPT-21025-MANDIBULAR-OSTEOMYELITIS-DEBRIDEMENT

    CPT 21025: Debridement for Mandibular Osteomyelitis

    CPT-21026-FACIAL-BONE-OSTEOMYELITIS-EXCISION

    CPT 21026: Excision/Debridement of Infected Facial Bone

    CPT-21029-BONE-TUMOR-CONTOURING-RESHAPING

    CPT 21029: Removal of Benign Bone Lesion by Contouring

    CPT-21030-ENUCLEATION-CURETTAGE-BENIGN-MAXILLARY-ZYGOMA-TUMOR

    CPT 21030: Enucleation/Curettage of Upper Jaw and Cheekbone

    Showing 1–10 of 22

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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