CPT code 20220 denotes a superficial bone biopsy, a diagnostic procedure to obtain bone tissue for pathological or microbiological examination. This code is used nationally to document and bill for procedures aimed at evaluating suspected bone lesions, infections, or other localized bone pathology when sampling from superficial sites is indicated. Accurate coding supports appropriate clinical documentation, care coordination, and claims adjudication across payers.

Key payers covered in the analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context, common sites of service, and the role of this procedure in diagnostic workups. The publication also summarizes typical billing considerations, commonly reported modifiers, and how payers may categorize the service for coverage and payment purposes.

This report is intended for a national audience and will help clinicians, coders, and revenue cycle professionals understand when CPT code 20220 is applicable, what settings it is most often performed in, and what types of information to expect in payer guidance and benchmark reporting. Data not provided in the input (such as specific payer fee schedules or utilization benchmarks) are noted where applicable.