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    v1.0.28
    OpenPayerBilling CodesAutografts/Tissue Cultured AutograftCPT cpt-15151-tissue-cultured-epidermal-autograft-additional-cm2
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    CPT 15151: Tissue Cultured Epidermal Autograft, Additional 1 cm2

    Medicare pays $127 on average nationally for this procedure.

    CPT code 15151 describes coverage for application of a tissue cultured epidermal autograft to an open wound or burn on the trunk, arms, or legs, billed per additional 1 cm2 of grafted skin (used for each additional 1 cm2 after the first 25 cm2, up to 75 cm2); this is a surgical skin grafting service typically provided in an operating room or procedure suite for wound and burn reconstruction.

    For related coverage guidance, see recent payer policy updates: Onychomycosis diagnostic testing and coverage, Topical Acne-Non-Retinoid Products, Dermatology - Vtama Drug Quantity Management Policy - Per Days.

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    Table of contents

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    • Billing CodesCPT, HCPCS, DRG & more
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    Clinical & Coding Specifications

    Clinical Context

    A 45-year-old male with a deep partial-thickness burn involving 60 cm2 of the right thigh following a workplace thermal injury undergoes surgical management. Initial debridement and wound bed preparation are performed in the operating room under general anesthesia. After adequate hemostasis and confirmation of a healthy granulating wound bed, a tissue-cultured epidermal autograft is applied. The first 25 cm2 is reported with the primary graft code (not shown here); 15151 is then used to report each additional 1 cm2 up to 75 cm2 of grafted skin beyond the initial 25 cm2, so this procedure will require multiple units of 15151 to account for the additional 35 cm2. Typical workflow includes preoperative evaluation, operative debridement, graft application, dressing placement, and postoperative wound care instructions with planned outpatient follow-up for graft assessment.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    15100Tissue cultured epidermal autograft, first 25 sq cm or less, trunk, arms, legs; initial areaRepresents the initial unit of cultured epidermal autograft reported for the first 25 cm2; 15151 is reported for additional area beyond this initial unit.
    15150Tissue cultured epidermal autograft, first 25 sq cm or less, scalp, neck, hands, feet, genitalia; initial areaIndicates initial cultured epidermal autograft for other anatomic sites; relevant if graft involves different site coding conventions.
    11042Debridement, muscle and/or fascia (extensive)May be performed prior to grafting to prepare the wound bed when deeper debridement is required.
    11043Debridement including boneUsed if necrotic bone debridement is required before graft placement.
    97597Debridement (e.g., high pressure lavage) non-selective, first 20 sq cm or lessRelevant for serial wound care and bedside debridement before definitive grafting.
    13160Secondary closure of surgical wound or scarMay be used when adjunctive procedures are performed to close donor or adjacent wounds during the same operative episode.

    Related Modifiers

    14 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…

    Showing 1–10 of 14

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208800000XUrology PhysicianA urologist manages benign and malignant medical and surgical disorders of the genitourinary system and the adrenal gland. This specialist has compreh…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    2279G1100XGeneral Care Registered Respiratory TherapistThis level of care includes diagnostics testing, therapeutics, monitoring, rehabilitation of patients with disorders of the cardiopulmonary system, as…
    251J00000XNursing Care AgencyA Nursing Care Agency is an entity that provides skilled nursing care through the services of a Registered Nurse (RN) or a Licensed Practical Nurse (L…
    103TP0016XPrescribing (Medical) PsychologistA licensed, doctoral-level psychologist authorized to prescribe and has undergone specialized education and training in preparation for prescriptive p…
    2279P4000XPatient Transport Registered Respiratory TherapistTransport respiratory therapist provide patient assessment, initiation of treatment modalities and continued monitoring of patient status of the criti…

    Related ICD-10-CM Codes

    18 rows

    ICD-10-CM CodeDescription
    E11.621Type 2 diabetes mellitus with foot ulcer
    I83.013Varicose veins of right lower extremity with ulcer of ankle
    L89.213Pressure ulcer of right hip, stage 3
    L90.5Scar conditions and fibrosis of skin
    L97.309Non-pressure chronic ulcer of unspecified ankle with unspecified severity
    L97.419Non-pressure chronic ulcer of right heel and midfoot with unspecified severity
    L98.9Disorder of the skin and subcutaneous tissue, unspecified
    S01.81XALaceration without foreign body of other part of head, initial encounter
    S01.81XDLaceration without foreign body of other part of head, subsequent encounter
    S21.011ALaceration without foreign body of right breast, initial encounter

    Showing 1–10 of 18

    Related Payer Policy Updates

    Specialty: Dermatology1 / 3

    5 rows

    PolicyPayerEffective Date
    Onychomycosis diagnostic testing and coverageOscar Health2026-10-01
    Topical Acne-Non-Retinoid ProductsCigna2026-08-15
    Dermatology - Vtama Drug Quantity Management Policy - Per DaysCigna2026-08-15
    Medical Necessity Guidelines: Acne and Rosacea Medicationsharvard pilgrim health care2026-08-11
    Winlevi (clascoterone 1% cream) — Topical AcneCigna2026-08-01

    Related Codes

    CPT-15040-SKIN-HARVEST-TISSUE-CULTURED-AUTOGRAFT

    CPT 15040: Harvest of Skin for Tissue Cultured Skin Autograft (≤100 cm2)

    CPT-15050-PINCH-GRAFT-SKIN-GRAFTING-SMALL-DEFECT

    CPT 15050: Pinch Graft, Skin, Up to 2 cm

    CPT-15100-SPLIT-THICKNESS-AUTOGRAFT-TRUNK-ARMS-LEGS

    CPT 15100: Split-Thickness Autograft from Trunk/Arms/Legs

    CPT-15101-SPLIT-THICKNESS-AUTOGRAFT-ADDITIONAL-100CM2

    CPT 15101: Split-Thickness Autograft, Additional 100 cm²

    CPT-15110-EPIDERMAL-AUTOGRAFT-TRUNK-ARMS-LEGS

    CPT 15110: Epidermal Autograft, Trunk/Arms/Legs

    CPT-15111-EPIDERMAL-AUTOGRAFT-TRUNK-ARMS-LEGS-ADDITIONAL

    CPT 15111: Epidermal Autograft, Trunk/Arms/Legs (per 100 cm2)

    CPT-15115-EPIDERMAL-AUTOGRAFT-FACE-AND-SENSITIVE-AREAS

    CPT 15115: Epidermal Autograft for Face/Scalp/Hands/Feet

    CPT-15116-EPIDERMAL-AUTOGRAFT-FACE-SCALP-HANDS-FEET

    CPT 15116: Epidermal Autograft for Face, Hands, Feet, Multiple Digits

    CPT-15120-SPLIT-THICKNESS-AUTOGRAFT-FACE-HANDS-FEET

    CPT 15120: Split‑Thickness Autograft, Face/Scalp (first 100 sq cm)

    CPT-15121-SPLIT-THICKNESS-AUTOGRAFT-ADDITIONAL-100-SQ-CM

    CPT 15121: Split-Thickness Autograft for Face, Scalp, Eyelids, Mouth, Neck, Ears

    Showing 1–10 of 27

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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