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    v1.0.28
    OpenPayerBilling CodesExcision-Malignant Lesions Procedures on the SkinCPT cpt-11646-excision-malignant-lesion-face-gt4cm
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    CPT 11646: Excision of Malignant Lesion of Face, >4.0 cm

    Medicare pays $530 on average nationally for this procedure.

    CPT code 11646 describes surgical excision of a malignant skin lesion on the face, ears, eyelids, nose, or lips with margins for a lesion greater than 4.0 cm in diameter, performed as a procedural surgical excision typically in an outpatient clinic, ambulatory surgical center, or hospital outpatient setting.

    For related coverage guidance, see recent payer policy updates: Onychomycosis diagnostic testing and coverage, Topical Acne-Non-Retinoid Products, Dermatology - Vtama Drug Quantity Management Policy - Per Days.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old patient presents to a dermatologic or surgical clinic with a biopsy-confirmed malignant cutaneous tumor (for example, squamous cell carcinoma or basal cell carcinoma) located on the nose measuring greater than 4.0 cm in maximum diameter. The provider evaluates the lesion, reviews the pathology, obtains informed consent, and schedules an excision in an ambulatory surgical center or hospital outpatient department. On the day of service the patient undergoes local anesthesia with sedation or general anesthesia as clinically indicated; the surgeon excises the lesion with appropriate margins and performs necessary reconstruction (primary closure, flap, or graft) to restore form and function of the face. Specimens are labeled and sent to pathology for permanent section analysis. Postoperative instructions and wound care are provided, and follow-up visits are arranged for wound check and pathology review. Typical site of service: outpatient surgical center or hospital outpatient department. Service type: surgical excision of malignant skin lesion with margins on cosmetically and functionally sensitive facial areas.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11646Excision, malignant lesion including margins, face, ears, eyelids, nose, lips; excised diameter over 4.0 cmThis is the primary procedure for large malignant cutaneous lesions on the face.
    14040Adjacent tissue transfer or rearrangement, trunk; simpleUsed when local flap reconstruction of the surgical defect is required after excision (select technique based on anatomic site).
    15271Full-thickness graft, nose; complex, including cartilage graft when performedUsed when full-thickness skin grafting is performed to reconstruct a facial defect post-excision.
    88305Level IV surgical pathology, gross and microscopic examinationUsed for permanent pathology evaluation of excised malignant specimens to determine margins and tumor characteristics.
    99024Postoperative follow-up visit global period - routine postoperative careUsed for routine postoperative visit within the global period for wound check and follow-up.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    57CPT® modifier -57 (“Decision for Surgery”) is appended to an Evaluation and Management (E/M) service when that encounter results in the initial decision to perform a major surgery (a procedure with a…- Use modifier 57 when an E/M service provided by the same provider (or same tax ID) on the day of or the day before a major surgical procedure (90‑day global period) results in the initial decision…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    208C00000XColon & Rectal Surgery PhysicianA colon and rectal surgeon is trained to diagnose and treat various diseases of the intestinal tract, colon, rectum, anal canal and perianal area by m…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    2472B0301XBiomedical Engineering TechnicianNone
    174400000XSpecialistAn individual educated and trained in an applied knowledge discipline used in the performance of work at a level requiring knowledge and skills beyond…
    207WX0108XUveitis and Ocular Inflammatory Disease (Ophthalmology) PhysicianAn ophthalmologist who specializes in the treatment of intraocular inflammation, scleritis, keratitis and infectious disorders affecting the eye and i…

    Related ICD-10-CM Codes

    19 rows

    ICD-10-CM CodeDescription
    C44.311Basal cell carcinoma of skin of nose
    C44.319Basal cell carcinoma of skin of other parts of face
    C44.511Basal cell carcinoma of skin of breast
    C44.519Basal cell carcinoma of skin of other part of trunk
    C44.611Basal cell carcinoma of skin of unspecified upper limb, including shoulder
    C44.612Basal cell carcinoma of skin of right upper limb, including shoulder
    C44.619Basal cell carcinoma of skin of left upper limb, including shoulder
    C44.711Basal cell carcinoma of skin of unspecified lower limb, including hip
    C44.712Basal cell carcinoma of skin of right lower limb, including hip
    C44.719Basal cell carcinoma of skin of left lower limb, including hip

    Showing 1–10 of 19

    Related Payer Policy Updates

    Specialty: Dermatology1 / 3

    10 rows

    PolicyPayerEffective Date
    Onychomycosis diagnostic testing and coverageOscar Health2026-10-01
    Topical Acne-Non-Retinoid ProductsCigna2026-08-15
    Dermatology - Vtama Drug Quantity Management Policy - Per DaysCigna2026-08-15
    Medical Necessity Guidelines: Acne and Rosacea Medicationsharvard pilgrim health care2026-08-11
    Pharmacologic Treatment of PsoriasisPremera Bluecross2026-08-01
    Winlevi (clascoterone 1% cream) — Topical AcneCigna2026-08-01
    Spevigo (spesolimab‑sbzo) for generalized pustular psoriasisUnitedHealthcare2026-08-01
    Onychomycosis Testingblue cross blue shield - louisiana2026-08-01
    Spesolimab-sbzo (Spevigoblue cross blue shield - tennessee2026-07-31
    Home ultraviolet light therapy equipment for skin conditionsselect_health2026-07-01

    Related Codes

    CPT-11600-EXCISION-MALIGNANT-LESION-05-CM-TRUNK-ARMS-LEGS

    CPT 11600: Excision of Malignant Lesion, ≤0.5 cm, Trunk/Arms/Legs

    CPT-11601-EXCISION-MALIGNANT-LESION-TRUNK-ARMS-LEGS-0-6-1-0-CM

    CPT 11601: Excision of Malignant Skin Lesion, Trunk/Arms/Legs, 0.6–1.0 cm

    CPT-11602-EXCISION-MALIGNANT-LESION-TRUNK-ARMS-LEGS-1-1-2-0CM

    CPT 11602: Excision of Malignant Lesion, Trunk/Arms/Legs 1.1–2.0 cm

    CPT-11603-EXCISION-MALIGNANT-LESION-TRUNK-ARMS-LEGS-2-1-3-0-CM

    CPT 11603: Excision of Malignant Lesion, Trunk/Arms/Legs 2.1–3.0 cm

    CPT-11604-EXCISION-MALIGNANT-LESION-TRUNK-ARMS-LEGS-3-1-4-0-CM

    CPT 11604: Excision of Malignant Lesion, Trunk/Arms/Legs 3.1–4.0 cm

    CPT-11606-EXCISION-MALIGNANT-LESION-TRUNK-ARMS-LEGS-OVER-4CM

    CPT 11606: Excision of Malignant Skin Lesion >4.0 cm on Trunk/Arms/Legs

    CPT-11620-EXCISION-MALIGNANT-SKIN-LESION-SMALL-DIAMETER-SCALP-NECK-HANDS-FEET-GENITALIA

    CPT 11620: Excision of Malignant Skin Lesion, ≤0.5 cm

    CPT-11621-EXCISION-MALIGNANT-LESION-06-10-MM-SCALP-NECK-HANDS-FEET-GENITALIA

    CPT 11621: Excision of Malignant Skin Lesion, 0.6–1.0 cm

    CPT-11622-EXCISION-MALIGNANT-LESION-1-1-TO-2CM-SCALP-NECK-HANDS-FEET-GENITALIA

    CPT 11622: Excision of Malignant Skin Lesion 1.1–2.0 cm

    CPT-11623-EXCISION-MALIGNANT-SKIN-LESION-2-1-3CM-SCALP-NECK-HANDS-FEET-GENITALIA

    CPT 11623: Excision of Malignant Lesion, 2.1–3.0 cm, Scalp/Neck/Hands/Feet/Genitalia

    Showing 1–10 of 17

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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