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    v1.0.30
    OpenPayerBilling CodesStereotactic Blood-Brain Barrier Disruption using Microbubble Resonators ProcedureCPT cpt-0947t-mr-guided-blood-brain-barrier-disruption-microbubble-enhanced
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    CPT 0947T: MR-Guided Low-Intensity Focused Ultrasound for BBB Disruption

    CPT code 0947T describes an MR-guided low-intensity focused ultrasound procedure to transiently disrupt the blood–brain barrier in a targeted brain region using microbubble resonators to concentrate blood-based biomarkers at the site; service type: image-guided therapeutic neurosurgical procedure; typical site of service: inpatient or outpatient hospital setting with MRI and stereotactic capabilities (stereotactic navigation and frame placement may be included if performed).

    For related coverage guidance, see recent payer policy updates: Navigated Transcranial Magnetic Stimulation for Preoperative Brain Mapping, Navigated Transcranial Magnetic Stimulation for Preoperative Brain Mapping, Navigated Transcranial Magnetic Stimulation for Preoperative Brain Mapping.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old patient with mild cognitive impairment and clinical suspicion for early Alzheimer disease is referred for an investigational MR-guided low-intensity focused ultrasound (LIFU) procedure to transiently disrupt the blood–brain barrier (BBB) at a targeted hippocampal region to enhance local concentration of blood-based biomarkers. The pre-procedure workflow includes neurologic consultation, informed consent detailing investigational nature and risks, preoperative MRI for stereotactic planning, anesthesia evaluation, and placement of a stereotactic frame or head fixation device. On the day of service, the patient undergoes MR-guided LIFU with intravenous microbubble contrast administration; intra-procedural MRI sequences confirm target localization and BBB disruption. Post-procedure monitoring in the recovery area includes neurologic assessment and a post-procedure MRI to document the treatment effect. Imaging and professional components may be billed separately if applicable.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    70553Magnetic resonance (MR) brain with and without contrast; including diffusion, perfusion when performedPre- and post-procedure diagnostic and planning MRI sequences used for target localization and treatment verification.
    61783Stereotactic radiosurgery, non–invasive, when performed — initially listed for intracranial lesion localization (note: included here for workflow relevance)May relate to stereotactic planning/targeting workflows; some stereotactic navigation techniques overlap in preprocedural planning.
    76937Ultrasound guidance for vascular access requiring imaging documentationUsed for ultrasound guidance at intravenous access sites for microbubble administration when documented and billed separately.
    99152Moderate sedation services provided by the same physician performing the diagnostic or therapeutic service (initial 15–30 minutes)If moderate sedation is provided by the proceduralist, moderate sedation services may be reported per payer rules.
    763763D rendering with interpretation and reporting of CT, MRI, ultrasound, or other tomographic modalityAdvanced 3D planning and visualization services for accurate targeting and navigation when applicable.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2084P0800X
    207RG0300X
    363LF0000X
    2086S0105X
    363A00000X
    2278H0200X
    2080A0000X
    2080P0201X

    Related Payer Policy Updates

    Specialty: Neurology/Neurosurgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Navigated Transcranial Magnetic Stimulation for Preoperative Brain Mappingpremerabluecrossofwashington2027-02-05
    Navigated Transcranial Magnetic Stimulation for Preoperative Brain Mappingpremerabluecrossofwashington2027-02-05
    Navigated Transcranial Magnetic Stimulation for Preoperative Brain Mappingpremerabluecrossofwashington2027-02-05
    Calcitonin Gene-Related Peptide (CGRP) Inhibitors: Vyepti (eptinezumab-jjmr)Mass General Brigham Health Plan2027-01-04
    Clinical Review Criteria Intraoperative Neurophysiological Monitoring (IONM)Kaiser Permanente2027-01-01
    Open Neuroplasty Lumbar PlexusCigna2026-12-15
    Laser Interstitial Thermal TherapyCigna2026-11-15
    Remote Electrical Neuromodulation for Migraines (i.e., Nerivio®)bcbsvermont2026-11-01
    Artificial Cervical Intervertebral Discuniverahealthcare2026-10-15
    Lumbar Microdiscectomyuniverahealthcare2026-10-15

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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