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    v1.0.28
    OpenPayerBilling CodesIntraoperative Assessment for Abnormal Breast TissueCPT cpt-0945t-intraoperative-fluorescence-imaging-partial-mastectomy
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    CPT 0945T: Fluorescence Imaging Assessment During Partial Mastectomy

    CPT code 0945T describes an add-on intraoperative service using computer-aided fluorescence imaging during a partial mastectomy to assess the surgical site for residual abnormal (tumor) tissue; service type: intraoperative imaging adjunct to tumor resection; typical site of service: operating room during breast-conserving surgery (partial mastectomy).

    For related coverage guidance, see recent payer policy updates: Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults, Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in Adults, Site of Service Ambulatory Service Center (ASC) Select.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a woman diagnosed with early-stage invasive breast carcinoma or ductal carcinoma in situ (DCIS) presenting for a breast-conserving surgery (partial mastectomy/lumpectomy). Preoperative workup includes imaging (mammography, ultrasound, often MRI) and core needle biopsy confirming malignancy. Intraoperatively, after excision of the targeted lesion with appropriate margins, the surgeon requests the add-on computer-aided fluorescence imaging service to assess the surgical bed for residual tumor tissue. The imaging system uses a fluorescent agent and real-time computer-assisted analysis to highlight areas of abnormal uptake that may represent residual tumor. If residual tissue is identified, the surgeon performs additional targeted excision to achieve clear margins. Typical workflow: preoperative planning and informed consent for partial mastectomy with possible intraoperative imaging; induction of anesthesia; partial mastectomy performed; application of fluorescence agent (if not pre-injected) and activation of imaging; interpretation of imaging results by the operating surgeon; additional resection as indicated; specimen sent to pathology for margin assessment. Typical site of service: hospital operating room or ambulatory surgical center during a partial mastectomy procedure.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    19301Partial mastectomy, lumpectomy, or excision of breast lesion; single lesionThis is the primary procedure during which the add-on fluorescence imaging (0945T) is performed to assess margins.
    88305Level IV surgical pathology, gross and microscopic examinationPathology code used for histologic analysis of excised breast tissue and margin assessment after intraoperative imaging-guided resection.
    77046Magnetic resonance imaging, breast, without and with contrast material, bilateralPreoperative breast MRI often used in surgical planning for partial mastectomy when multifocal disease is a concern.
    19318Reduction mammoplasty (when performed concurrently for symmetry)May be performed by plastic surgeons for oncoplastic reconstruction in conjunction with lumpectomy and intraoperative imaging.
    99152Anesthesia for procedures on patient of age 5 years or older, moderate sedation services provided by the same physician or other qualified health care professional performing the diagnostic or therapeutic serviceExample of anesthesia/sedation services that support the operative setting where intraoperative imaging is used.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    207YX0905XOtolaryngology/Facial Plastic Surgery PhysicianAn otolaryngologist who specializes in the diagnosis and surgical treatment of head and neck conditions.
    213ES0103XFoot & Ankle Surgery PodiatristPodiatric Medicine & Surgery Service Providers · Podiatrist
    1744R1102XResearch Study SpecialistOther Service Providers · Specialist
    261QG0250XGenetics Clinic/CenterAn entity, facility, or distinct part of a facility providing analysis of family history, genetic laboratory testing and analysis, diagnosis of geneti…
    282E00000XLong Term Care HospitalLong-term care hospitals (LTCHs) furnish extended medical and rehabilitative care to individuals who are clinically complex and have multiple acute or…

    Related Payer Policy Updates

    Specialty: General Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01
    Inpatient Surgical Site of ServiceProvidence Health Plan2026-07-01
    Removal of Implantable DevicesBlue Cross Blue Shield - Rhode Island2026-07-01

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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