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    v1.0.30
    OpenPayerBilling CodesAI-Based Facial Phenotype AnalysisCPT cpt-0731t-ai-facial-analysis-genetic-syndrome-screening
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    CPT 0731T: Facial AI Analysis for Genetic Syndrome Identification

    CPT code 0731T describes use of artificial intelligence (AI) technology to analyze a patient’s facial features to assist in identification of rare genetic syndromes, with the provider completing a written interpretation report based on the analysis; the service is an AI-assisted diagnostic interpretation typically performed in an outpatient clinic or specialty genetics/medical genetics setting using facial image capture and computational analysis.

    For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency, Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policy.

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    Clinical & Coding Specifications

    Clinical Context

    A pediatric genetics clinic evaluates an infant with multiple dysmorphic facial features and developmental delay. The clinician captures standardized facial photographs during the visit and submits them to a certified AI-based facial analysis platform. The AI analyzes facial morphology to generate similarity scores against known syndromic facial phenotypes and provides ranked candidate genetic syndromes. The provider reviews the AI report, integrates it with the clinical exam, family history, and prior testing (such as CMA or targeted gene panels), documents the interpretation and conclusions in the chart, and uses the information to guide further genetic testing or referral to specialty services. Typical workflow steps: intake and consent for facial image use, standardized image capture, AI processing, provider review of the AI-generated report, documentation of findings and clinical interpretation, and ordering confirmatory genetic testing if indicated. Typical sites of service include outpatient genetics clinics, pediatric specialty clinics, and telemedicine consultations where secure image transmission is permitted.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    0731TThe provider uses artificial intelligence (AI) technology to analyze a patient’s facial features, such as to help identify rare genetic syndromes. The provider completes a report based on interpretation of the data.Primary AI facial analysis service; documents interpretation used to guide further evaluation.
    99213Office or other outpatient visit for the evaluation and management of an established patient, typically 15 minutes.Commonly used for the clinical visit during which images are captured and the AI report is reviewed and documented.
    99203Office or other outpatient visit for the evaluation and management of a new patient, typically 30 minutes.Used for new genetics consultations that include image acquisition and AI-assisted analysis.
    81406Molecular pathology procedure, genomic sequence analysis, small panel (eg, 5-50 genes)Often ordered after AI analysis suggests a specific syndromic suspicion to confirm genetic etiology.
    88271FISH, each probe; initial single targetMay be ordered when AI findings suggest a microdeletion/microduplication syndrome requiring targeted cytogenetic testing.
    G0452Intensive outpatient behavioral health or complex care planning (example adjunct code)May be used in complex care coordination visits following AI-guided diagnosis; included as an example of related care planning codes.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    95Modifier 95 indicates that a service was provided via synchronous, real‑time audio‑video telehealth rather than in‑person. Per CMS, AAPC and professional associations, append modifier 95 to claim…- Use modifier 95 to indicate a service was furnished via synchronous, real‑time audiovisual telehealth (a live audio‑video conference between patient and provider) rather than in‑person. - Pair…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    363L00000X
    207X00000X
    246Z00000X
    2471C3402X
    163WS0200X
    225000000X
    1744R1103X

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Carrier Testing Panels for Genetic Diseases (for Kentucky Only)UnitedHealthcare2026-10-01
    Genetic Testing for Neurological Disorders (for Kansas Only)UnitedHealthcare2026-10-01
    Genetic and Molecular TestingProvidence Health Plan2026-10-01
    Cell-Free Fetal DNA Testing (for Idaho Only)UnitedHealthcare2026-10-01
    Next Generation Sequencing for Minimal Residual Disease DetectionProvidence Health Plan2026-10-01
    Pharmacogenetic Panel Testing (for Kansas Only)UnitedHealthcare2026-10-01
    Non-Covered Genetic Panel TestsProvidence Health Plan2026-10-01

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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