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    v1.0.28
    OpenPayerBilling CodesTransperineal Prostate Ablation Through LaserCPT cpt-0655t-transperineal-prostate-laser-ablation-mr-fused-ultrasound
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    CPT 0655T: Transperineal Laser Ablation of Malignant Prostate Tissue

    CPT code 0655T describes a transperineal laser ablation procedure in which the provider uses a laser to destroy malignant prostate tissue with transrectal imaging guidance and enhanced ultrasound such as MR–fused images; this service is a minimally invasive image-guided prostate cancer ablation typically performed in an outpatient surgical suite or ambulatory procedure center using real-time ultrasound fused with magnetic resonance images for targeting.

    For related coverage guidance, see recent payer policy updates: Radiation oncology coverage and treatment delivery guidelines, Proton Beam Therapy, Radiation and Oncologic Procedures.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a man aged 60–80 years with biopsy-proven localized prostate cancer who is a candidate for focal or partial gland ablation. The patient often presents after rising prostate-specific antigen (PSA) levels, suspicious multiparametric MRI findings, and targeted biopsy confirming clinically significant cancer (e.g., Grade Group 1–3 localized to discrete prostate regions). The clinical workflow includes preprocedure evaluation (history, physical, laboratory testing including PSA, imaging review with MRI and transrectal ultrasound correlation), informed consent discussing transperineal ablative approach and alternatives, perioperative planning (antibiotic prophylaxis, anticoagulation management), and selection of fusion imaging strategy to integrate prior MRI with real-time transrectal ultrasound.

    On the day of service the patient is positioned for a transperineal approach under general or regional anesthesia in an ambulatory surgery center or hospital outpatient setting. The proceduralist obtains MR–fused ultrasound guidance to localize the tumor, inserts transperineal needles or laser fiber(s), and performs laser ablation of malignant prostate tissue. Postprocedure monitoring includes immediate recovery observation for bleeding, urinary retention, infection, and pain management, with discharge instructions and planned follow-up PSA and imaging to assess treatment response.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    55866Laparoscopy, surgical prostatectomy, retropubic radical prostatectomy or simple prostatectomy (separate codes exist for radical vs simple)Not typically performed on same day with 0655T; listed as related genitourinary surgical codes for context in prostate cancer management decisions.
    52000Cystourethroscopy, with or without irrigation and evacuationMay be performed before or after ablation to evaluate hematuria or urinary tract issues related to the procedure.
    76942Ultrasonic guidance for needle placement (e.g., biopsy, aspiration, injection), imaging supervision and interpretationSupports transrectal ultrasound guidance and may be reported when separate ultrasound guidance services are provided in addition to the ablation.
    55874Laparoscopic radical prostatectomy, retropubic or perineal approaches (robotic-assisted when appropriate)Alternative definitive surgical treatment; useful for documenting other procedures in the prostate cancer treatment pathway.
    88305Surgical pathology, gross and microscopic examinationReported for prostate biopsy specimens obtained in diagnostic workup prior to planning 0655T.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RP1001XPulmonary Disease PhysicianAn internist who treats diseases of the lungs and airways. The pulmonologist diagnoses and treats cancer, pneumonia, pleurisy, asthma, occupational an…
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    225XM0800XMental Health Occupational TherapistOccupational therapists provide treatment for people recovering from a mental or physical illness to regain their independence and stability and to en…
    261QS0112XOral and Maxillofacial Surgery Clinic/CenterThe specialty of dentistry which includes the diagnosis, surgical and adjunctive treatment of diseases, injuries and defects involving both the functi…
    261QR0400XRehabilitation Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    213EG0000XDeactivated - Podiatrist
    163WX0106XOccupational Health Registered NurseNursing Service Providers · Registered Nurse

    Related Payer Policy Updates

    Specialty: Radiation Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Radiation oncology coverage and treatment delivery guidelinesevicore2026-11-05
    Proton Beam Therapyuniversityofutahhealthplans2026-10-25
    Radiation and Oncologic ProceduresUnitedHealthcare2026-09-01
    Electronic Brachytherapy for Nonmelanoma Skin CancerBluecross Idaho2026-07-30
    Surface Radiation Therapy for Treatment of Non-Melanoma Skin Cancereocco2026-07-09
    Radiofrequency Ablation of Tumors Outside the LiverProvidence Health Plan2026-07-01
    Therapeutic Radiopharmaceuticals in Oncology (Lutathera, Pluvicto, Xofigo) Coverage CriteriaBlue Cross Blue Shield - North Carolina2026-07-01
    Irreversible Electroporation (IRE) of Tumors Other Than LiverBlue Cross Blue Shield - Rhode Island2026-06-01
    Intensity Modulated Radiation TherapyAmbetter Georgia2026-06-01
    Irreversible Electroporation (IRE) — NanoKnife (Preauthorization Required)Blue Cross Blue Shield - Nebraska2026-06-01

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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