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    v1.0.31
    OpenPayerBilling CodesTransnasal EGD and Capsule Endoscopy ProceduresCPT cpt-0653t-transnasal-egd-with-biopsy
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    CPT 0653T: Diagnostic Esophagogastroduodenoscopy with Biopsy

    CPT code 0653T describes an esophagogastroduodenoscopy (EGD) performed by inserting an endoscope through the nose into the esophagus, stomach, and duodenum for diagnostic evaluation with collection of one or more biopsy specimens; service type: diagnostic endoscopy with biopsy; typical site of service: outpatient endoscopy suite or hospital outpatient department (ENT or gastroenterology procedural area).

    For related coverage guidance, see recent payer policy updates: Achalasia and Gastroesophageal Reflux Disease (GERD) - Minimally Invasive Procedures - Medical Policy, Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Gastric Pacing/Gastric Electrical Stimulation (GES).

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient presents to the gastroenterology clinic with progressive dyspepsia, iron-deficiency anemia, and intermittent upper abdominal pain. The provider schedules a diagnostic upper endoscopy with biopsy to evaluate for peptic ulcer disease, gastritis, celiac disease, Helicobacter pylori infection, or malignancy. The procedure is performed in an outpatient endoscopy suite or hospital endoscopy unit under conscious sedation or monitored anesthesia care. The provider advances a flexible endoscope transnasally or transorally through the esophagus into the stomach and duodenum, visually inspects mucosa, and obtains one or more targeted mucosal biopsy specimens for histopathologic analysis. Specimens are labeled and sent to the pathology laboratory with clinical indications documented in the operative note and pathology requisition. Typical documentation includes indication(s), consent, sedation type, endoscopic findings, number and site of biopsies, complications (if any), and post-procedure instructions.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43239Upper gastrointestinal endoscopy including esophagus, stomach, and either the duodenum and/or jejunum, with biopsy, single or multipleAlternative widely used CPT code for diagnostic upper endoscopy with biopsies; often billed for standard esophagogastroduodenoscopy procedures.
    43235Upper gastrointestinal endoscopy, flexible, transoral; diagnostic, including collection of specimen(s) by brushing or lavage when performed (separate procedure)Diagnostic endoscopy without biopsy specimens or with brushing/lavage; may be used when biopsy is not obtained.
    43249Removal of foreign body from esophagus, stomach, or duodenum during upper endoscopyPerformed during the same session if a foreign body is encountered and removed in addition to diagnostic biopsy.
    43255Upper gastrointestinal endoscopy, flexible, transoral; with endoscopic mucosal resection (EMR)Performed when biopsy identifies lesions requiring resection during the same or subsequent endoscopic session.
    88305Level IV surgical pathology, gross and microscopic examinationCommon pathology CPT code used to report histologic examination of endoscopic biopsy specimens sent to pathology.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    74Modifier ‑74 indicates an outpatient hospital or ASC procedure that was discontinued after anesthesia was administered and after the procedure had begun. Use this modifier when anesthesia (local,…- Use modifier -74 when a procedure in an outpatient hospital or ASC setting is terminated after anesthesia has been administered and after the procedure has commenced (for example, after incision,…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    208800000X
    363LF0000X
    163WX0106X
    1744R1102X
    207YP0228X
    2279P1005X
    363LP0222X

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Achalasia and Gastroesophageal Reflux Disease (GERD) - Minimally Invasive Procedures - Medical PolicyHealth-New-England2027-02-01
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Gastric Pacing/Gastric Electrical Stimulation (GES)Cigna2026-11-15
    Percutaneous Electrical Nerve Field Stimulation for Disorders of Gut-Brain Interactionpremerabluecrossofwashington2026-11-06
    Percutaneous electrical nerve field stimulation for disorders of gut-brain interactionpremerabluecrossofwashington2026-11-06
    Percutaneous Electrical Nerve Field Stimulation for Disorders of Gut-Brain Interactionpremerabluecrossofwashington2026-11-06
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Surgical Site of Care - Colonoscopy and Sigmoidoscopyregence2026-11-01
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15

    Related Codes

    CPT-0651T-MAGNETICALLY-CONTROLLED-CAPSULE-ENDOSCOPY-ESOPHAGUS-STOMACH

    CPT 0651T: Magnetically Steered Capsule Endoscopy of Esophagus and Stomach

    CPT-0652T-TRANSNASAL-UPPER-ENDOSCOPY-DIAGNOSTIC

    CPT 0652T: Nasal Esophagogastroduodenoscopy, Diagnostic

    CPT-0654T-TRANSNASAL-UPPER-GI-ENDOSCOPY-CATHETER-PLACEMENT

    CPT 0654T: Transnasal Diagnostic Esophagogastroduodenoscopy with Lumen Catheter

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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