CPT 0615U: iDart Lyme IgM ImmunoBlot Kit (Proprietary Lyme Serology)

CPT code 0615U is a Proprietary Laboratory Analyses (PLA) code for the iDart™ Lyme IgM ImmunoBlot Kit (ID–FISH Technology Inc.), an immunoassay that detects IgM antibodies to 26 recombinant Borrelia burgdorferi protein groups to support evaluation for Lyme disease; service type: targeted serologic diagnostic testing for Lyme disease; typical site of service: clinical laboratory or reference laboratory performing the proprietary immunoblot assay.

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CPT 0615U: iDart Lyme IgM ImmunoBlot Kit (Proprietary Lyme Serology)

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Get alerted when payer policies referencing 0615U are released or updated.

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Clinical & Coding Specifications

Clinical Context

A 34-year-old patient presents to an outpatient infectious disease clinic in late spring with a recent history of a tick bite and new onset of fever, headache, myalgias, and an expanding erythematous rash suspicious for erythema migrans. The clinician performs a history and physical exam, documents possible early Lyme disease, and orders serologic testing to aid diagnosis. The laboratory performs the proprietary iDart™ Lyme IgM ImmunoBlot Kit (report with CPT code 0615U) on the patient’s serum to detect IgM antibodies to 26 recombinant Borrelia burgdorferi protein groups. The test is processed in a certified clinical laboratory (CLIA-waived not applicable; typically CLIA high-complexity or moderate-complexity lab) and results are returned to the ordering clinician to support clinical evaluation for acute or early Lyme disease.

Typical clinical workflow:

Clinician evaluates patient and documents indication for Lyme serology.
Blood specimen (serum) is collected, labeled, and shipped to a laboratory that performs the iDart™ Lyme IgM ImmunoBlot Kit.
Laboratory performs the proprietary immunoblot assay and reports qualitative/semistructured results to the ordering provider with interpretation notes about IgM reactivity.
Ordering clinician integrates test results with clinical findings to guide patient management and decisions about antibiotic therapy or further testing.

Typical site of service: outpatient physician office, urgent care clinic, or independent clinical laboratory performing specialized serologic testing.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`0615U`	iDart™ Lyme IgM ImmunoBlot Kit — Proprietary Laboratory Analyses (PLA) code for detection of IgM antibodies to 26 recombinant Borrelia burgdorferi protein groups	Primary code used to report this specific proprietary Lyme IgM immunoblot assay.
`86617`	Antibody; Borrelia burgdorferi	Commonly ordered as an initial enzyme immunoassay (EIA) or screening antibody test before confirmatory immunoblot testing in a two-tiered algorithm.
`86618`	Antibody; Borrelia burgdorferi, IgM	Alternative/general code for IgM antibody testing for Lyme disease when a non-proprietary method is used; may be used if payer requires mapping when PLA code is not recognized.
`86320`	Immunoassay for infectious agent antibody, qualitative or semi-quantitative; single-step method	May describe certain screening immunoassays performed prior to specific immunoblot confirmation.
`88120`	Cytopathology, fluid, except nongynecologic	Not typically related; included here only if specimen processing or specialized cytology is needed in rare atypical presentations. (If unrelated, Data not available in the input.)

Note: If local payer or laboratory policies require, the screening EIA (86617) is often performed before or in parallel with confirmatory immunoblot assays such as the proprietary 0615U test to support Lyme disease diagnosis.

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
24	Modifier 24 denotes an unrelated evaluation and management (E/M) service performed by the same physician or qualified healthcare professional during a postoperative global period. Per CPT guidance,…	- Use modifier 24 when you report an evaluation and management (E/M) service performed by the same physician or same-specialty group during a procedure’s postoperative global period that is unrelated…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
204R00000X	Electrodiagnostic Medicine Physician	Electrodiagnostic medicine is the medical subspecialty that applies neurophysiologic techniques to diagnose, evaluate, and treat patients with impairm…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
261QP2300X	Primary Care Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center
332BC3200X	Customized Equipment (DME)	Suppliers · Durable Medical Equipment & Medical Supplies
261QR0207X	Mobile Mammography Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center
207QG0300X	Geriatric Medicine (Family Medicine) Physician	A family medicine physician with special knowledge of the aging process and special skills in the diagnostic, therapeutic, preventive and rehabilitati…

Related Payer Policy Updates

Specialty: Genetic & Molecular Testing1 / 3

10 rows

Policy	Payer	Effective Date
RTM Testing of Homocysteine Metabolism-Related Conditions	Oscar Health	2026-10-01
Multimarker Serum Testing Related to Ovarian Cancer	Blue Cross Blue Shield - Rhode Island	2026-09-01
Genomic Profiling for Selecting Targeted Cancer Therapies	Blue Cross Blue Shield - Rhode Island	2026-09-01
Whole Exome and Whole Genome Sequencing for Diagnosis of Genetic Disorders	Blue Cross Blue Shield - Rhode Island	2026-09-01
Biomarker and Genetic/Molecular Testing Coverage and Prior Authorization	Blue Cross Blue Shield - Rhode Island	2026-09-01
Non-Invasive Prenatal Testing (NIPT)	univerahealthcare	2026-08-17
Lumizyme (alglucosidase alfa) — Pompe Disease (acid alpha‑glucosidase deficiency)	Cigna	2026-08-15
Molecular Oncology Testing for Solid Tumor Cancer Diagnosis, Prognosis, and Treatment Decisions	Colorado Rocky Mountain Health Plans	2026-08-01
Molecular Oncology Testing for Hematologic Cancer Diagnosis, Prognosis, and Treatment Decisions	Colorado Rocky Mountain Health Plans	2026-08-01
Carrier Testing Panels for Genetic Diseases	Colorado Rocky Mountain Health Plans	2026-08-01

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Typical clinical workflow:

Clinician evaluates patient and documents indication for Lyme serology.
Blood specimen (serum) is collected, labeled, and shipped to a laboratory that performs the iDart™ Lyme IgM ImmunoBlot Kit.
Laboratory performs the proprietary immunoblot assay and reports qualitative/semistructured results to the ordering provider with interpretation notes about IgM reactivity.
Ordering clinician integrates test results with clinical findings to guide patient management and decisions about antibiotic therapy or further testing.

Typical site of service: outpatient physician office, urgent care clinic, or independent clinical laboratory performing specialized serologic testing.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`0615U`	iDart™ Lyme IgM ImmunoBlot Kit — Proprietary Laboratory Analyses (PLA) code for detection of IgM antibodies to 26 recombinant Borrelia burgdorferi protein groups	Primary code used to report this specific proprietary Lyme IgM immunoblot assay.
`86617`	Antibody; Borrelia burgdorferi	Commonly ordered as an initial enzyme immunoassay (EIA) or screening antibody test before confirmatory immunoblot testing in a two-tiered algorithm.
`86618`	Antibody; Borrelia burgdorferi, IgM	Alternative/general code for IgM antibody testing for Lyme disease when a non-proprietary method is used; may be used if payer requires mapping when PLA code is not recognized.
`86320`	Immunoassay for infectious agent antibody, qualitative or semi-quantitative; single-step method	May describe certain screening immunoassays performed prior to specific immunoblot confirmation.
`88120`	Cytopathology, fluid, except nongynecologic	Not typically related; included here only if specimen processing or specialized cytology is needed in rare atypical presentations. (If unrelated, Data not available in the input.)

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
24	Modifier 24 denotes an unrelated evaluation and management (E/M) service performed by the same physician or qualified healthcare professional during a postoperative global period. Per CPT guidance,…	- Use modifier 24 when you report an evaluation and management (E/M) service performed by the same physician or same-specialty group during a procedure’s postoperative global period that is unrelated…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
204R00000X	Electrodiagnostic Medicine Physician	Electrodiagnostic medicine is the medical subspecialty that applies neurophysiologic techniques to diagnose, evaluate, and treat patients with impairm…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
261QP2300X	Primary Care Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center
332BC3200X	Customized Equipment (DME)	Suppliers · Durable Medical Equipment & Medical Supplies
261QR0207X	Mobile Mammography Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center
207QG0300X	Geriatric Medicine (Family Medicine) Physician	A family medicine physician with special knowledge of the aging process and special skills in the diagnostic, therapeutic, preventive and rehabilitati…

Related Payer Policy Updates

Specialty: Genetic & Molecular Testing1 / 3

10 rows

Policy	Payer	Effective Date
RTM Testing of Homocysteine Metabolism-Related Conditions	Oscar Health	2026-10-01
Multimarker Serum Testing Related to Ovarian Cancer	Blue Cross Blue Shield - Rhode Island	2026-09-01
Genomic Profiling for Selecting Targeted Cancer Therapies	Blue Cross Blue Shield - Rhode Island	2026-09-01
Whole Exome and Whole Genome Sequencing for Diagnosis of Genetic Disorders	Blue Cross Blue Shield - Rhode Island	2026-09-01
Biomarker and Genetic/Molecular Testing Coverage and Prior Authorization	Blue Cross Blue Shield - Rhode Island	2026-09-01
Non-Invasive Prenatal Testing (NIPT)	univerahealthcare	2026-08-17
Lumizyme (alglucosidase alfa) — Pompe Disease (acid alpha‑glucosidase deficiency)	Cigna	2026-08-15
Molecular Oncology Testing for Solid Tumor Cancer Diagnosis, Prognosis, and Treatment Decisions	Colorado Rocky Mountain Health Plans	2026-08-01
Molecular Oncology Testing for Hematologic Cancer Diagnosis, Prognosis, and Treatment Decisions	Colorado Rocky Mountain Health Plans	2026-08-01
Carrier Testing Panels for Genetic Diseases	Colorado Rocky Mountain Health Plans	2026-08-01

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 0615U: iDart Lyme IgM ImmunoBlot Kit (Proprietary Lyme Serology)

Sign up for cpt 0615U policy alerts

OpenPayer

CPT 0615U: iDart Lyme IgM ImmunoBlot Kit (Proprietary Lyme Serology)

Sign up for cpt 0615U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

References

CPT 0615U: iDart Lyme IgM ImmunoBlot Kit (Proprietary Lyme Serology)

Sign up for cpt 0615U policy alerts

CPT 0615U: iDart Lyme IgM ImmunoBlot Kit (Proprietary Lyme Serology)

Sign up for cpt 0615U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

What does CPT code 0615U represent?

In what clinical situations is the iDart™ Lyme IgM ImmunoBlot (0615U) typically ordered?

Where is the 0615U test usually performed and reported from?

How does 0615U relate to other Lyme serology CPT codes like 86617 or 86618?

Which diagnosis codes are commonly associated with ordering CPT 0615U?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

What does CPT code 0615U represent?

In what clinical situations is the iDart™ Lyme IgM ImmunoBlot (0615U) typically ordered?

Where is the 0615U test usually performed and reported from?

How does 0615U relate to other Lyme serology CPT codes like 86617 or 86618?

Which diagnosis codes are commonly associated with ordering CPT 0615U?

References