CPT 0605U: Tryptase Gene Copy Number Analysis by dPCR

CPT code 0605U is a Proprietary Laboratory Analyses (PLA) code for Tryptase Gene Copy Number Analysis by digital PCR performed by Virant Diagnostics Inc.; the test uses digital polymerase chain reaction to determine copy number of the TPSAB1 gene from whole blood DNA and reports genotype-specific interpretation classifying alpha tryptase copy number as normal or abnormal. Service type: molecular diagnostic test using digital PCR. Typical site of service: clinical diagnostic laboratory or reference laboratory performing proprietary genetic testing on blood specimens.

Customize your policy alerts

Sign up for cpt 0605U policy alerts

Get alerted when payer policies referencing 0605U are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Explore openpayer tools

View all tools

CPT 0605U: Tryptase Gene Copy Number Analysis by dPCR

Customize your policy alerts

Sign up for cpt 0605U policy alerts

Get alerted when payer policies referencing 0605U are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A typical patient is an adult referred by an allergist or immunologist for evaluation of suspected hereditary alpha tryptasemia after clinical features such as recurrent idiopathic anaphylaxis, unexplained systemic mast cell activation symptoms (flushing, abdominal pain, diarrhea, urticaria), elevated baseline serum tryptase, or a family history of elevated tryptase. The ordering clinician collects whole blood in EDTA and sends the specimen to Virant Diagnostics Inc. for 0605U Tryptase Gene Copy Number Analysis by digital PCR. The laboratory performs dPCR to quantify TPSAB1 alpha-tryptase copy number; results are reported as genotype-specific copy number with algorithmic classification as normal or abnormal. The report is reviewed by the ordering clinician to integrate genetic results with clinical findings for diagnostic clarification and family counseling. Typical site of service is an outpatient clinic, specialty allergy/immunology office, or a reference clinical laboratory; specimen collection occurs in a phlebotomy clinic or outpatient lab service.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`0605U`	Tryptase Gene Copy Number Analysis by dPCR (Virant Diagnostics Inc.)	Primary proprietary laboratory analyte; report of TPSAB1 alpha tryptase copy number used for diagnosis of hereditary alpha tryptasemia.
`36415`	Collection of venous blood by venipuncture	Typically performed prior to sending whole blood specimen to the reference lab for `0605U` testing.
`99000`	Handling and/or conveyance of specimen to reference lab (clinical laboratory fee)	Used by some facilities to bill specimen handling and shipping costs when sending to an outside lab.
`0000U`	(Placeholder PLA example)	Other PLA tests for related molecular assays may be used in parallel in specialized diagnostic workflows (use specific PLA codes for actual tests).
`81162`	BRCA1/BRCA2 analysis (example of high-complexity molecular testing)	Represents similar high-complexity molecular reporting workflows; listed to illustrate molecular testing context rather than direct clinical overlap.

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
P1	Modifier P1 indicates an ASA Physical Status I — a normal healthy patient — and is appended to anesthesia CPT codes (00100–01999) based on the anesthesiologist’s clinical assessment. It documents the…	- When to apply: Use modifier P1 on anesthesia CPT codes (00100–01999) when the anesthesia provider assigns ASA Physical Status I — a normal healthy patient (non‑smoker, minimal or no alcohol use).…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
207R00000X	Internal Medicine Physician	A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
2080P0210X	Pediatric Nephrology Physician	A pediatrician who deals with the normal and abnormal development and maturation of the kidney and urinary tract, the mechanisms by which the kidney c…
261QS0112X	Oral and Maxillofacial Surgery Clinic/Center	The specialty of dentistry which includes the diagnosis, surgical and adjunctive treatment of diseases, injuries and defects involving both the functi…
2085N0904X	Nuclear Radiology Physician	A radiologist who is involved in the analysis and imaging of radionuclides and radiolabeled substances in vitro and in vivo for diagnosis and the admi…
363AM0700X	Medical Physician Assistant	Physician Assistants & Advanced Practice Nursing Providers · Physician Assistant

Related ICD-10-CM Codes

23 rows

ICD-10-CM Code	Description
D47.Z2	Castleman disease
D75.9	Disease of blood and blood-forming organs, unspecified
D89.1	Cryoglobulinemia
E66.9	Obesity, unspecified
F45.9	Somatoform disorder, unspecified
I10	Essential (primary) hypertension
J30.9	Allergic rhinitis, unspecified
J45.909	Unspecified asthma, uncomplicated
K52.9	Noninfective gastroenteritis and colitis, unspecified
L50.0	Allergic urticaria

Showing 1–10 of 23

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Explore openpayer tools

View all tools

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`0605U`	Tryptase Gene Copy Number Analysis by dPCR (Virant Diagnostics Inc.)	Primary proprietary laboratory analyte; report of TPSAB1 alpha tryptase copy number used for diagnosis of hereditary alpha tryptasemia.
`36415`	Collection of venous blood by venipuncture	Typically performed prior to sending whole blood specimen to the reference lab for `0605U` testing.
`99000`	Handling and/or conveyance of specimen to reference lab (clinical laboratory fee)	Used by some facilities to bill specimen handling and shipping costs when sending to an outside lab.
`0000U`	(Placeholder PLA example)	Other PLA tests for related molecular assays may be used in parallel in specialized diagnostic workflows (use specific PLA codes for actual tests).
`81162`	BRCA1/BRCA2 analysis (example of high-complexity molecular testing)	Represents similar high-complexity molecular reporting workflows; listed to illustrate molecular testing context rather than direct clinical overlap.

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
P1	Modifier P1 indicates an ASA Physical Status I — a normal healthy patient — and is appended to anesthesia CPT codes (00100–01999) based on the anesthesiologist’s clinical assessment. It documents the…	- When to apply: Use modifier P1 on anesthesia CPT codes (00100–01999) when the anesthesia provider assigns ASA Physical Status I — a normal healthy patient (non‑smoker, minimal or no alcohol use).…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
207R00000X	Internal Medicine Physician	A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
2080P0210X	Pediatric Nephrology Physician	A pediatrician who deals with the normal and abnormal development and maturation of the kidney and urinary tract, the mechanisms by which the kidney c…
261QS0112X	Oral and Maxillofacial Surgery Clinic/Center	The specialty of dentistry which includes the diagnosis, surgical and adjunctive treatment of diseases, injuries and defects involving both the functi…
2085N0904X	Nuclear Radiology Physician	A radiologist who is involved in the analysis and imaging of radionuclides and radiolabeled substances in vitro and in vivo for diagnosis and the admi…
363AM0700X	Medical Physician Assistant	Physician Assistants & Advanced Practice Nursing Providers · Physician Assistant

Related ICD-10-CM Codes

23 rows

ICD-10-CM Code	Description
D47.Z2	Castleman disease
D75.9	Disease of blood and blood-forming organs, unspecified
D89.1	Cryoglobulinemia
E66.9	Obesity, unspecified
F45.9	Somatoform disorder, unspecified
I10	Essential (primary) hypertension
J30.9	Allergic rhinitis, unspecified
J45.909	Unspecified asthma, uncomplicated
K52.9	Noninfective gastroenteritis and colitis, unspecified
L50.0	Allergic urticaria

Showing 1–10 of 23

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 0605U: Tryptase Gene Copy Number Analysis by dPCR

Sign up for cpt 0605U policy alerts

OpenPayer

CPT 0605U: Tryptase Gene Copy Number Analysis by dPCR

Sign up for cpt 0605U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

CPT 0605U: Tryptase Gene Copy Number Analysis by dPCR

Sign up for cpt 0605U policy alerts

CPT 0605U: Tryptase Gene Copy Number Analysis by dPCR

Sign up for cpt 0605U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does CPT code 0605U represent?

For which clinical scenarios is 0605U typically ordered?

What specimen and collection procedure are associated with 0605U?

Are there common related CPT or billing codes that appear with 0605U?

Which diagnoses on the encounter might justify sending the 0605U test based on the provided content?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does CPT code 0605U represent?

For which clinical scenarios is 0605U typically ordered?

What specimen and collection procedure are associated with 0605U?

Are there common related CPT or billing codes that appear with 0605U?

Which diagnoses on the encounter might justify sending the 0605U test based on the provided content?

References