CPT code 0587U is a Proprietary Laboratory Analyses (PLA) code assigned to the SafeDrugs test from Astraeus Lab LLC and Quantlio Technologies. The test employs liquid chromatography–tandem mass spectrometry (LC MS/MS) on urine or saliva to quantify a broad panel of drugs and metabolites, verify sample integrity, and produce an algorithm-generated risk score indicating potential for adverse drug interactions or toxicity. As a PLA code, 0587U applies only to this specific manufacturer’s assay, which affects coding clarity and payer review.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise national overview of what the code represents, typical sites of service, and clinical context for laboratory-based drug monitoring and toxicity risk assessment. The publication summarizes common modifiers and highlights where data was not provided.

This report helps billing managers, laboratory directors, and policy analysts understand the clinical function of the assay, the limited scope of a PLA code, and the payer landscape to consider when coding and submitting claims. Data not available in the input are noted where applicable.