Summary & Overview
CPT 0582U: Rapid Whole Genome Sequencing (Mayo Clinic)
CPT code 0582U is a Proprietary Laboratory Analyses (PLA) code that represents Rapid Whole Genome Sequencing offered exclusively by Mayo Clinic. This test sequences a patient’s entire genome quickly to detect a broad range of genetic variants and supports rapid diagnostic evaluation, particularly in acute or complex clinical scenarios where timely genetic information may alter management.
Key national payers in scope include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. The publication provides a concise overview of clinical utility and coding context, payer coverage landscape, benchmarking where available, and policy considerations affecting access to proprietary rapid genome sequencing services.
Readers will gain: a clear description of the service associated with CPT code 0582U, the typical clinical and laboratory settings for specimen collection and processing, summaries of payer coverage status and common claims considerations, and pointers to where to find additional policy or clinical guidance. Data not available in the input is explicitly noted where applicable.
Billing Code Overview
CPT code 0582U is a Proprietary Laboratory Analyses (PLA) code that applies exclusively to a single laboratory test: Rapid Whole Genome Sequencing performed by Mayo Clinic. The test uses rapid whole genome sequencing to analyze a person’s entire DNA sequence and identify various types of genetic changes, reporting detected variants.
Service Type: Rapid Whole Genome Sequencing (clinical diagnostic genetic testing)
Typical Site of Service: Clinical laboratory processing with specimens collected in outpatient clinics, inpatient settings, or specialized specimen collection sites; samples accepted include blood, saliva, or tissue.
Clinical & Coding Specifications
Clinical Context
A neonate or infant hospitalized in the neonatal intensive care unit (NICU) with unexplained, severe, or life‑threatening illness such as refractory seizures, metabolic crisis, encephalopathy, or multisystem failure is evaluated for a genetic cause. Rapid whole genome sequencing from Mayo Clinic (0582U) is ordered when clinicians require expedited, comprehensive genomic analysis to identify single‑gene disorders, copy number variants, structural variants, or other pathogenic changes that may explain the presentation and guide urgent management. Typical workflow: the treating neonatologist or geneticist obtains informed consent, collects a blood sample (or saliva/tissue if blood not available), ships the specimen under Mayo Clinic’s specimen handling instructions, and submits the test with relevant clinical history and provisional ICD‑10 diagnoses. Mayo Clinic performs rapid whole genome sequencing, bioinformatic analysis, and clinical interpretation, returning a report of detected variants and their clinical significance to the ordering clinician to inform diagnosis, prognosis, targeted therapy, or palliative decisions.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
00 | Anesthesia modifier — default; not used for this lab test | Not applicable to this lab assay; do not append unless specifically required by a payer (rare) |