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    v1.0.30
    OpenPayerBilling CodesAblation Procedures (Breast/Prostate)CPT cpt-0581t-breast-cryoablation-percutaneous-tumor-destruction
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    CPT 0581T: Percutaneous Cryoablation of Small Malignant Breast Tumors

    CPT code 0581T describes a minimally invasive percutaneous cryoablation procedure in which the provider uses extreme cold to ablate one or more small malignant tumors in a single breast; service type: image-guided tumor ablation / minimally invasive breast procedure; typical site of service: outpatient surgical suite, ambulatory surgery center, or image-guided procedure room.

    For related coverage guidance, see recent payer policy updates: Positron Emission Tomography (PET) - Non-Oncologic Applications, Positron Emission Tomography (PET) Oncologic Applications, Magnetic Resonance Imaging (MRI) of the Prostate.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 62-year-old woman with a newly diagnosed small, localized primary breast carcinoma identified on screening mammography and confirmed by core needle biopsy. The tumor is unifocal, ≤2 cm, and located peripherally in one breast with imaging (ultrasound and/or MRI) showing no multifocal disease and no clinically suspicious axillary nodes. After multidisciplinary review, the patient elects a minimally invasive, breast-conserving approach using percutaneous cryoablation as definitive therapy or as a bridge to surgery for medical comorbidity reduction of tumor burden.

    Pre-procedure workflow includes: clinical evaluation by a breast surgeon or interventional radiologist, imaging localization with ultrasound and/or mammography, review of pathology confirming malignant histology, informed consent discussing risks/benefits and alternatives, and pre-procedure anesthesia assessment. On the day of service the patient undergoes image-guided percutaneous placement of one or more cryoprobes into the tumor under local anesthesia with conscious sedation or monitored anesthesia care. Ablation is performed with freeze–thaw cycles using cryotherapy to achieve tumor necrosis. Post-procedure imaging is used to document probe position and immediate ablation zone. The patient is observed in recovery and provided discharge instructions for wound care and follow-up imaging and oncology/surgical follow-up. This procedure is typically performed in an outpatient ambulatory surgery center or hospital outpatient department and billed using the cryoablation breast tumor code 0581T for one breast.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    19083Percutaneous ablation of breast tumor(s), radiofrequency or microwave, includes imaging guidance and monitoring, when performedAlternative percutaneous thermal ablation modality used for similar clinical indications; may be considered when cryoablation is not selected.
    19280Injection for breast tumor localization (eg, wire, seed)Pre-procedure localization code when the lesion requires placement of a localization device prior to ablation or surgical excision.
    76942Ultrasonic guidance for needle placement (eg, biopsy, aspiration, injection, localization device), imaging supervision and interpretationUsed when ultrasound guidance is used for probe placement during percutaneous cryoablation.
    77012Computed tomography guidance for needle placement (eg, biopsy, aspiration, injection, localization device)Used when CT guidance is utilized for probe placement and monitoring of ablation zone.
    90772Anesthesia for procedures involving extensive tissue manipulation of the breast (monitored anesthesia care)Billed when monitored anesthesia care or anesthesia services are provided in conjunction with 0581T.
    11042Debridement, subcutaneous tissue (first 20 sq cm or less)Potentially used for management of ablation-related wound complications requiring debridement in follow-up care.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    208000000X
    363L00000X
    207L00000X
    133VN1101X
    363A00000X
    172M00000X
    163WR0400X

    Related Payer Policy Updates

    Specialty: Radiology/Diagnostic Imaging1 / 3

    10 rows

    PolicyPayerEffective Date
    Positron Emission Tomography (PET) - Non-Oncologic Applicationsuniverahealthcare2026-10-15
    Positron Emission Tomography (PET) Oncologic Applicationsuniverahealthcare2026-10-15
    Magnetic Resonance Imaging (MRI) of the Prostateuniverahealthcare2026-10-15
    Diagnostic and Therapeutic Radiology ServicesUnitedHealthcare2026-10-01
    Diagnostic Dynamic Spinal Visualization and Vertebral Motion Analysis (for Nebraska Only)UnitedHealthcare2026-10-01
    Diagnostic Dynamic Spinal Visualization and Vertebral Motion Analysis (for New Mexico Only)UnitedHealthcare2026-10-01
    Diagnostic Dynamic Spinal Visualization and Vertebral Motion AnalysisUnitedHealthcare2026-10-01
    Diagnostic Dynamic Spinal Visualization and Vertebral Motion Analysis (for North Carolina Only)UnitedHealthcare2026-10-01
    Diagnostic Dynamic Spinal Visualization and Vertebral Motion Analysis (for Kentucky Only)UnitedHealthcare2026-10-01
    Diagnostic Dynamic Spinal Visualization and Vertebral Motion Analysis (for Kansas Only)UnitedHealthcare2026-10-01

    Related Codes

    CPT-0582T-TRANSURETHRAL-WATER-VAPOR-THERMAL-ABLATION-PROSTATE-MALIGNANCY

    CPT 0582T: Transurethral Water Vapor Thermal Ablation of Malignant Prostate Tissue

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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