CPT 0571U: LiquidHALLMARK® ctDNA/ctRNA NGS 80-gene Panel

CPT code 0571U is a Proprietary Laboratory Analyses (PLA) code that reports LiquidHALLMARK® testing by Lucence Health Inc., a blood-based next-generation sequencing (NGS) assay that evaluates 80 genes from circulating tumor DNA (ctDNA) and 10 genes from circulating tumor RNA (ctRNA) to identify clinically actionable genetic variants relevant to cancer treatment decisions; service type: NGS-based comprehensive ctDNA/ctRNA molecular profiling, typical site of service: outpatient blood draw or clinical laboratory processing.

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CPT 0571U: LiquidHALLMARK® ctDNA/ctRNA NGS 80-gene Panel

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Get alerted when payer policies referencing 0571U are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A typical patient is an adult with known or suspected advanced solid tumor disease who requires comprehensive tumor genomic profiling to guide targeted therapy selection or enrollment in clinical trials. A medical oncologist orders the LiquidHALLMARK® circulating tumor DNA (ctDNA) and circulating tumor RNA (ctRNA) panel when tissue biopsy is unavailable, insufficient, or when real-time assessment of tumor genomics is needed to detect actionable alterations, resistance mutations, or gene fusions. The clinical workflow: the patient presents at an oncology clinic or outpatient infusion center; a phlebotomy draw is performed for a liquid biopsy (blood specimen) and sent to Lucence Health Inc. for Proprietary Laboratory Analysis reported under 0571U. The laboratory performs next-generation sequencing (NGS) of ctDNA (80 genes) and ctRNA (10 genes), analyzes single-nucleotide variants, insertions/deletions, copy-number alterations, and fusions, and returns a report of clinically actionable variants to the ordering oncologist. Results inform treatment selection (targeted therapy, immunotherapy considerations), detection of acquired resistance, or eligibility for clinical trials. Typical sites of service include outpatient hospital clinics, physician offices, and commercial laboratory specimen collection centers.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`36415`	Collection of venous blood by venipuncture	Preceding specimen collection required to obtain blood for the LiquidHALLMARK® NGS test
`88172`	Immunohistochemistry (IHC) interpretation (single or first stain)	May be performed in parallel when tissue IHC is used alongside liquid biopsy for biomarker correlation
`81479`	Unlisted molecular pathology procedure	Used when a specific molecular test lacks an established CPT code and for reporting supplemental or novel molecular analyses not covered by the PLA code
`0001U`	Proprietary laboratory test (example PLA)	Other PLA codes may be billed for different manufacturers/tests in the molecular oncology workflow; listed here as a category comparator
`G0452`	Specimen collection in a mobile unit	Relevant when blood collection for the test occurs via mobile phlebotomy services in some programs

Related Modifiers

5 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
76	Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…	- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
57	CPT® modifier -57 (“Decision for Surgery”) is appended to an Evaluation and Management (E/M) service when that encounter results in the initial decision to perform a major surgery (a procedure with a…	- Use modifier 57 when an E/M service provided by the same provider (or same tax ID) on the day of or the day before a major surgical procedure (90‑day global period) results in the initial decision…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RC0000X	Cardiovascular Disease Physician	An internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
363L00000X	Nurse Practitioner	(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
207LP2900X	Pain Medicine (Anesthesiology) Physician	An anesthesiologist who provides a high level of care, either as a primary physician or consultant, for patients experiencing problems with acute, chr…
332900000X	Non-Pharmacy Dispensing Site	A site other than a pharmacy that dispenses medicinal preparations under the supervision of a physician to patients for self-administration. (e.g. phy…
207UN0903X	In Vivo & In Vitro Nuclear Medicine Physician	A nuclear medicine physician who specializes in in vivo and in vitro nuclear medicine.
2085R0204X	Vascular & Interventional Radiology Physician	A radiologist who diagnoses and treats diseases by various radiologic imaging modalities. These include fluoroscopy, digital radiography, computed tom…
213ES0000X	Sports Medicine Podiatrist	Podiatric Medicine & Surgery Service Providers · Podiatrist

Related ICD-10-CM Codes

29 rows

ICD-10-CM Code	Description
C16.9	Malignant neoplasm of stomach, unspecified
C18.9	Malignant neoplasm of colon, unspecified
C22.0	Liver cell carcinoma
C25.9	Malignant neoplasm of pancreas, unspecified
C33	Malignant neoplasm of trachea
C34.11	Malignant neoplasm of upper lobe, right bronchus or lung
C34.90	Malignant neoplasm of unspecified part of unspecified bronchus or lung
C43.9	Malignant melanoma of skin, unspecified
C44.90	Unspecified malignant neoplasm of skin, unspecified
C50.919	Malignant neoplasm of unspecified site of unspecified female breast

Showing 1–10 of 29

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`36415`	Collection of venous blood by venipuncture	Preceding specimen collection required to obtain blood for the LiquidHALLMARK® NGS test
`88172`	Immunohistochemistry (IHC) interpretation (single or first stain)	May be performed in parallel when tissue IHC is used alongside liquid biopsy for biomarker correlation
`81479`	Unlisted molecular pathology procedure	Used when a specific molecular test lacks an established CPT code and for reporting supplemental or novel molecular analyses not covered by the PLA code
`0001U`	Proprietary laboratory test (example PLA)	Other PLA codes may be billed for different manufacturers/tests in the molecular oncology workflow; listed here as a category comparator
`G0452`	Specimen collection in a mobile unit	Relevant when blood collection for the test occurs via mobile phlebotomy services in some programs

Related Modifiers

5 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
76	Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…	- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
57	CPT® modifier -57 (“Decision for Surgery”) is appended to an Evaluation and Management (E/M) service when that encounter results in the initial decision to perform a major surgery (a procedure with a…	- Use modifier 57 when an E/M service provided by the same provider (or same tax ID) on the day of or the day before a major surgical procedure (90‑day global period) results in the initial decision…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RC0000X	Cardiovascular Disease Physician	An internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
363L00000X	Nurse Practitioner	(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
207LP2900X	Pain Medicine (Anesthesiology) Physician	An anesthesiologist who provides a high level of care, either as a primary physician or consultant, for patients experiencing problems with acute, chr…
332900000X	Non-Pharmacy Dispensing Site	A site other than a pharmacy that dispenses medicinal preparations under the supervision of a physician to patients for self-administration. (e.g. phy…
207UN0903X	In Vivo & In Vitro Nuclear Medicine Physician	A nuclear medicine physician who specializes in in vivo and in vitro nuclear medicine.
2085R0204X	Vascular & Interventional Radiology Physician	A radiologist who diagnoses and treats diseases by various radiologic imaging modalities. These include fluoroscopy, digital radiography, computed tom…
213ES0000X	Sports Medicine Podiatrist	Podiatric Medicine & Surgery Service Providers · Podiatrist

Related ICD-10-CM Codes

29 rows

ICD-10-CM Code	Description
C16.9	Malignant neoplasm of stomach, unspecified
C18.9	Malignant neoplasm of colon, unspecified
C22.0	Liver cell carcinoma
C25.9	Malignant neoplasm of pancreas, unspecified
C33	Malignant neoplasm of trachea
C34.11	Malignant neoplasm of upper lobe, right bronchus or lung
C34.90	Malignant neoplasm of unspecified part of unspecified bronchus or lung
C43.9	Malignant melanoma of skin, unspecified
C44.90	Unspecified malignant neoplasm of skin, unspecified
C50.919	Malignant neoplasm of unspecified site of unspecified female breast

Showing 1–10 of 29

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 0571U: LiquidHALLMARK® ctDNA/ctRNA NGS 80-gene Panel

Sign up for cpt 0571U policy alerts

OpenPayer

CPT 0571U: LiquidHALLMARK® ctDNA/ctRNA NGS 80-gene Panel

Sign up for cpt 0571U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

CPT 0571U: LiquidHALLMARK® ctDNA/ctRNA NGS 80-gene Panel

Sign up for cpt 0571U policy alerts

CPT 0571U: LiquidHALLMARK® ctDNA/ctRNA NGS 80-gene Panel

Sign up for cpt 0571U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does CPT 0571U represent and which test does it apply to?

In what clinical situations is the LiquidHALLMARK® test (0571U) typically ordered and how is the sample obtained?

Which related CPT codes or services should billing staff be aware of when submitting a claim for 0571U?

What modifiers are described for use with 0571U and when would they apply?

Which payers are noted as relevant for coverage or reimbursement considerations for CPT 0571U?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does CPT 0571U represent and which test does it apply to?

In what clinical situations is the LiquidHALLMARK® test (0571U) typically ordered and how is the sample obtained?

Which related CPT codes or services should billing staff be aware of when submitting a claim for 0571U?

What modifiers are described for use with 0571U and when would they apply?

Which payers are noted as relevant for coverage or reimbursement considerations for CPT 0571U?

References