CPT code 0554U is a Proprietary Laboratory Analyses (PLA) code for Smart PGT–SR by Igenomix® (Vitrolife Group™) and Thermo Fisher Scientific that evaluates IVF embryos by analyzing all 24 chromosomes from a trophectoderm biopsy to detect chromosomal abnormalities such as aneuploidy, abnormal ploidy and mosaicism, and that also reports a mitochondrial DNA score and quality control results; this is a laboratory genetic test (proprietary embryo aneuploidy screening) typically ordered as a diagnostic laboratory service performed in a specialized molecular genetics laboratory or reference testing facility for in vitro fertilization (IVF) embryo assessment prior to embryo transfer.

For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, Genomic Profiling for Selecting Targeted Cancer Therapies.