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CPT 0536U: Prenatal Detect RhD Test by Devyser Genomic Laboratories

CPT code 0536U identifies a single-vendor Proprietary Laboratory Analyses (PLA) test: the Prenatal Detect RhD by Devyser Genomic Laboratories. The assay determines fetal RhD status by PCR analysis of fetal cell-free DNA in maternal blood, targeting exon 4 of the RHD gene and including a GAPDH quality control. Nationally, this code matters for prenatal care pathways where RhD-negative pregnant individuals require non-invasive fetal RHD determination to guide antenatal management.

Key payers examined include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise clinical context for when the test is used (RhD-negative pregnant individuals from 10 weeks’ gestation), the service setting (laboratory processing of outpatient maternal blood samples), and the nature of the PLA designation (single-manufacturer coding). The publication summarizes coverage and payment benchmarks, common billing considerations, and policy implications for incorporating single-source genetic tests into prenatal care. Data not available in the input is noted where applicable, and the report focuses on national implications rather than state-specific policy.

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Billing Code Overview

CPT code 0536U is a Proprietary Laboratory Analyses (PLA) code for the Prenatal Detect RhD test by Devyser Genomic Laboratories. The test determines fetal RhD status by analyzing fetal cell-free DNA in maternal blood using polymerase chain reaction (PCR) targeted to exon 4 of the RHD gene, with a housekeeping gene (GAPDH) assayed to verify sample quality. Report 0536U only for the specific test performed by this manufacturer/laboratory.

Service type: Non-invasive prenatal genetic test (maternal blood, fetal cell-free DNA analysis)

Typical site of service: Clinical laboratory or reference laboratory processing maternal blood samples collected in an outpatient obstetrics setting

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CPT 0536U: Prenatal Detect RhD Test by Devyser Genomic Laboratories

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Billing Code Overview

Service type: Non-invasive prenatal genetic test (maternal blood, fetal cell-free DNA analysis)

Typical site of service: Clinical laboratory or reference laboratory processing maternal blood samples collected in an outpatient obstetrics setting

Clinical & Coding Specifications

Clinical Context

A pregnant individual, who tested RhD negative on routine prenatal blood typing, presents at 10–20 weeks' gestation for noninvasive fetal RhD genotyping. A peripheral maternal blood sample is collected and sent to Devyser Genomic Laboratories for the proprietary test reported as 0536U (Prenatal Detect RhD). The laboratory isolates cell‑free fetal DNA from maternal plasma and performs polymerase chain reaction (PCR) targeting exon 4 of the fetal RHD gene with an internal control (GAPDH) to confirm sample adequacy. Results returned as fetal RhD positive or negative guide antenatal management: Rh immune globulin administration decisions, antenatal counseling, and postpartum planning for hemolytic disease of the fetus/newborn surveillance. Typical workflow steps include order by obstetric clinician, phlebotomy at an outpatient prenatal clinic or ambulatory lab, courier to the performing laboratory, testing and reporting, and documentation placed in the maternal chart and communicated to the patient and obstetric care team. Typical site of service: outpatient prenatal clinic, ambulatory phlebotomy center, or hospital outpatient laboratory.

Coding Specifications

Modifier	Description	When to Use
`00`	Default, no modifier	Use when no special reporting modifier applies to the service.
`22`	Increased procedural services	Use when the laboratory documents significantly greater complexity, time, or resources for the test beyond usual; attach supporting documentation.
`52`	Reduced services	Use when the test was partially reduced or not completed as described by full protocol.
`53`	Discontinued procedure	Use when specimen collection or testing was started but discontinued for unavoidable clinical reasons.
`59`	Distinct procedural service	Use when another unrelated service is performed on the same day requiring separation from this test (use cautiously; lab PLA codes seldom require `59`).
`76`	Repeat procedure by same provider	Use when the test is repeated by the same lab during the same pregnancy for verification or confirmation.
`77`	Repeat procedure by another provider	Use when a second laboratory performs the repeat test and separate billing is warranted.
`90`	Reference (outside) laboratory	Use when the performing laboratory bills on behalf of or as a referencing lab to indicate outside lab processing.
`91`	Repeat clinical diagnostic laboratory test	Use when an identical test is performed on the same day and results are repeated for verification.

Taxonomy Code	Specialty	Notes
207Q00000X	Obstetrics & Gynecology	Ordering clinicians who commonly request prenatal RhD genotyping.
207L00000X	Maternal-Fetal Medicine	High‑risk pregnancy specialists ordering and interpreting fetal RhD results for alloimmunized patients.
1223G0001X	Clinical Molecular Genetics	Laboratory directors and molecular specialists performing PCR‑based assays.
182M00000X	Pathology	Pathologists or laboratory directors overseeing specialty genetic testing services.
174400000X	Phlebotomy	Outpatient phlebotomists who collect and process maternal blood specimens for cell‑free fetal DNA testing.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
Data not available in the input.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`81025`	Noninvasive prenatal determination of fetal RhD (note: not an official descriptor for this PLA)	Not applicable; include only as a conceptual contrast to `0536U` when different methods are used in some settings.
`36415`	Collection of venous blood by venipuncture	Performed prior to `0536U` to obtain the maternal blood sample for cell‑free fetal DNA analysis.
`G0480`	Laboratory test for detection of fetal RHD (example G‑code may vary by payer)	Some payers may use alternative or temporary codes for molecular prenatal RhD testing in reimbursement workflows.
`0000U`	Proprietary laboratory analyses — example PLA code format	Other PLA codes may exist for different labs' prenatal molecular tests; listed here as related by billing category.
`0001M`	Laboratory specimen handling/processing (example molecular pathology add‑on)	Ancillary laboratory processing codes may be billed in conjunction with molecular diagnostic testing depending on payer and lab billing practices.

CPT 0001U: PreciseType HEA Multiplex Erythrocyte Antigen Assay

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: Urine Metabolomic Polyp Risk Assay (PolypDX™)

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa™ (OVA1 Next Generation) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) Urine Gene Expression Risk Test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen with DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Panel, Gene Sequence Analysis

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Cordant CORE™ Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcript Testing

Showing 1–10 of 536

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

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Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`00`	Default, no modifier	Use when no special reporting modifier applies to the service.
`22`	Increased procedural services	Use when the laboratory documents significantly greater complexity, time, or resources for the test beyond usual; attach supporting documentation.
`52`	Reduced services	Use when the test was partially reduced or not completed as described by full protocol.
`53`	Discontinued procedure	Use when specimen collection or testing was started but discontinued for unavoidable clinical reasons.
`59`	Distinct procedural service	Use when another unrelated service is performed on the same day requiring separation from this test (use cautiously; lab PLA codes seldom require `59`).
`76`	Repeat procedure by same provider	Use when the test is repeated by the same lab during the same pregnancy for verification or confirmation.
`77`	Repeat procedure by another provider	Use when a second laboratory performs the repeat test and separate billing is warranted.
`90`	Reference (outside) laboratory	Use when the performing laboratory bills on behalf of or as a referencing lab to indicate outside lab processing.
`91`	Repeat clinical diagnostic laboratory test	Use when an identical test is performed on the same day and results are repeated for verification.

Taxonomy Code	Specialty	Notes
207Q00000X	Obstetrics & Gynecology	Ordering clinicians who commonly request prenatal RhD genotyping.
207L00000X	Maternal-Fetal Medicine	High‑risk pregnancy specialists ordering and interpreting fetal RhD results for alloimmunized patients.
1223G0001X	Clinical Molecular Genetics	Laboratory directors and molecular specialists performing PCR‑based assays.
182M00000X	Pathology	Pathologists or laboratory directors overseeing specialty genetic testing services.
174400000X	Phlebotomy	Outpatient phlebotomists who collect and process maternal blood specimens for cell‑free fetal DNA testing.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
Data not available in the input.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`81025`	Noninvasive prenatal determination of fetal RhD (note: not an official descriptor for this PLA)	Not applicable; include only as a conceptual contrast to `0536U` when different methods are used in some settings.
`36415`	Collection of venous blood by venipuncture	Performed prior to `0536U` to obtain the maternal blood sample for cell‑free fetal DNA analysis.
`G0480`	Laboratory test for detection of fetal RHD (example G‑code may vary by payer)	Some payers may use alternative or temporary codes for molecular prenatal RhD testing in reimbursement workflows.
`0000U`	Proprietary laboratory analyses — example PLA code format	Other PLA codes may exist for different labs' prenatal molecular tests; listed here as related by billing category.
`0001M`	Laboratory specimen handling/processing (example molecular pathology add‑on)	Ancillary laboratory processing codes may be billed in conjunction with molecular diagnostic testing depending on payer and lab billing practices.

CPT 0001U: PreciseType HEA Multiplex Erythrocyte Antigen Assay

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: Urine Metabolomic Polyp Risk Assay (PolypDX™)

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa™ (OVA1 Next Generation) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) Urine Gene Expression Risk Test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen with DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Panel, Gene Sequence Analysis

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Cordant CORE™ Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcript Testing

Showing 1–10 of 536

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

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Billing Code Overview

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Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References