CPT 0501U: QuantiDNA Colorectal Cancer Triage Test (cfDNA quantitative)

CPT code 0501U is a Proprietary Laboratory Analyses (PLA) code for the QuantiDNA™ Colorectal Cancer Triage Test by DiaCarta Inc., a blood-based cell–free DNA (cfDNA) quantitative measurement intended to help assess a patient’s risk for colorectal cancer; service type: proprietary laboratory test / molecular diagnostic assay; typical site of service: clinical laboratory or outpatient phlebotomy collection site.

Customize your policy alerts

Sign up for cpt 0501U policy alerts

Get alerted when payer policies referencing 0501U are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Explore openpayer tools

View all tools

CPT 0501U: QuantiDNA Colorectal Cancer Triage Test (cfDNA quantitative)

Customize your policy alerts

Sign up for cpt 0501U policy alerts

Get alerted when payer policies referencing 0501U are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A typical patient is a 55–75 year-old adult with a positive fecal immunochemical test (FIT), unexplained iron-deficiency anemia, a change in bowel habits, or a family history of colorectal cancer who is being evaluated noninvasively for colorectal cancer risk. The ordering clinician (primary care physician, gastroenterologist, or oncologist) orders the 0501U QuantiDNA™ Colorectal Cancer Triage Test to measure quantitative cell-free DNA (cfDNA) in a single peripheral blood sample. Blood is drawn in an outpatient laboratory, clinic, or ambulatory phlebotomy site; the specimen is shipped to DiaCarta Inc. or their designated reference lab for analysis. Results are returned to the ordering clinician and used as adjunctive information to guide decisions about need and timing of diagnostic colonoscopy, further imaging, or referral to gastroenterology. Typical clinical workflow: order placed in the electronic health record, specimen collection with standard venipuncture and appropriate tube, specimen labeling and shipment per lab instructions, laboratory analytic processing and reporting, and clinician review of results with patient to determine next steps in diagnostic evaluation or surveillance planning.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`0501U`	QuantiDNA™ Colorectal Cancer Triage Test — quantitative cfDNA assay (Proprietary Laboratory Analyses)	Primary PLA code for the specific cfDNA blood test reported by DiaCarta Inc.; used to document and bill this unique laboratory service
`36415`	Collection of venous blood by venipuncture	Performed at the time of specimen collection for sending blood to the reference laboratory
`99000`	Handling and/or conveyance of specimen for transfer from the physician's office to a laboratory	Use when the office bills for specimen transport services according to payer policy
`G0008`	Administration of fecal occult blood test (FOBT) by physician or other qualified health care professional	May appear in the workflow when stool-based screening tests were performed previously and results trigger triage testing
`88360`	Immunohistochemistry (IHC) (if reflex tissue testing performed)	Related when cfDNA findings prompt tissue-based confirmatory testing or molecular pathology consultation

Related Modifiers

5 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
57	CPT® modifier -57 (“Decision for Surgery”) is appended to an Evaluation and Management (E/M) service when that encounter results in the initial decision to perform a major surgery (a procedure with a…	- Use modifier 57 when an E/M service provided by the same provider (or same tax ID) on the day of or the day before a major surgical procedure (90‑day global period) results in the initial decision…
3P	The CPT Category II modifier -3P denotes a performance‑measure exclusion when a required quality action was not performed because of system‑level constraints. It is appended only to Category II…	- When to apply: Use CPT Category II modifier 3P only with Category II (‘‘F’’) codes when a specific quality measure’s specifications allow a system‑level exclusion — append 3P to indicate the…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207R00000X	Internal Medicine Physician	A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
2471C3401X	Computed Tomography Radiologic Technologist	A radiologic technologist who specializes in computed tomography (CT) and is appropriately educated and trained, consistent with nationally recognized…
133VN1004X	Pediatric Nutrition Registered Dietitian	An individual who is a Board Certified Specialist in Pediatric Nutrition and applies evidence-based nutrition knowledge in providing medical nutrition…
363LF0000X	Family Nurse Practitioner	Physician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
103TE1000X	Deactivated - Psychologist
103TP0814X	Psychoanalysis Psychologist	A psychologist whose specialty is distinguished from other specialties by its body of knowledge and its intensive treatment approaches. It aims at str…

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Explore openpayer tools

View all tools

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`0501U`	QuantiDNA™ Colorectal Cancer Triage Test — quantitative cfDNA assay (Proprietary Laboratory Analyses)	Primary PLA code for the specific cfDNA blood test reported by DiaCarta Inc.; used to document and bill this unique laboratory service
`36415`	Collection of venous blood by venipuncture	Performed at the time of specimen collection for sending blood to the reference laboratory
`99000`	Handling and/or conveyance of specimen for transfer from the physician's office to a laboratory	Use when the office bills for specimen transport services according to payer policy
`G0008`	Administration of fecal occult blood test (FOBT) by physician or other qualified health care professional	May appear in the workflow when stool-based screening tests were performed previously and results trigger triage testing
`88360`	Immunohistochemistry (IHC) (if reflex tissue testing performed)	Related when cfDNA findings prompt tissue-based confirmatory testing or molecular pathology consultation

Related Modifiers

5 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
57	CPT® modifier -57 (“Decision for Surgery”) is appended to an Evaluation and Management (E/M) service when that encounter results in the initial decision to perform a major surgery (a procedure with a…	- Use modifier 57 when an E/M service provided by the same provider (or same tax ID) on the day of or the day before a major surgical procedure (90‑day global period) results in the initial decision…
3P	The CPT Category II modifier -3P denotes a performance‑measure exclusion when a required quality action was not performed because of system‑level constraints. It is appended only to Category II…	- When to apply: Use CPT Category II modifier 3P only with Category II (‘‘F’’) codes when a specific quality measure’s specifications allow a system‑level exclusion — append 3P to indicate the…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207R00000X	Internal Medicine Physician	A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
2471C3401X	Computed Tomography Radiologic Technologist	A radiologic technologist who specializes in computed tomography (CT) and is appropriately educated and trained, consistent with nationally recognized…
133VN1004X	Pediatric Nutrition Registered Dietitian	An individual who is a Board Certified Specialist in Pediatric Nutrition and applies evidence-based nutrition knowledge in providing medical nutrition…
363LF0000X	Family Nurse Practitioner	Physician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
103TE1000X	Deactivated - Psychologist
103TP0814X	Psychoanalysis Psychologist	A psychologist whose specialty is distinguished from other specialties by its body of knowledge and its intensive treatment approaches. It aims at str…

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 0501U: QuantiDNA Colorectal Cancer Triage Test (cfDNA quantitative)

Sign up for cpt 0501U policy alerts

OpenPayer

CPT 0501U: QuantiDNA Colorectal Cancer Triage Test (cfDNA quantitative)

Sign up for cpt 0501U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

CPT 0501U: QuantiDNA Colorectal Cancer Triage Test (cfDNA quantitative)

Sign up for cpt 0501U policy alerts

CPT 0501U: QuantiDNA Colorectal Cancer Triage Test (cfDNA quantitative)

Sign up for cpt 0501U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT code 0501U represent?

In which clinical scenarios and workflow is the QuantiDNA™ test used?

Which other CPT codes commonly appear in the workflow with 0501U?

What modifiers are associated with billing 0501U and when are they used?

Which payers are referenced and does the page list reimbursement rates or coverage details?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT code 0501U represent?

In which clinical scenarios and workflow is the QuantiDNA™ test used?

Which other CPT codes commonly appear in the workflow with 0501U?

What modifiers are associated with billing 0501U and when are they used?

Which payers are referenced and does the page list reimbursement rates or coverage details?

References