Loading...

    Explore
    • Policy Monitoring
    • Live Policy Feed
    • Billing Codes
    • Healthcare Providers
    • Health Insurance Payers
    • States
    • Service Lines
    • Taxonomy Codes
    Lookup tools
    • Billing Code Lookup
    • CPT Modifier Lookup
    • Provider Taxonomy Code Lookup
    • Healthcare Provider & Facility Lookup
    • Health Insurance Payer Lookup
    • Payer Contact Directory

    Policy & Benchmark Tools

    • Prior Authorization Lookup
    • Coverage Criteria Lookup
    • Timely Filing Lookup
    • Billing Code Reimbursement Rates
    • Payer Comparison Dashboard
    • Facility Comparison Dashboard
    • All tools

    Company

    • About OpenPayer
    • Data Sources
    • Trek Health
    OpenPayerby Trek Health
    LinkedInYouTube

    © 2026 Trek Health. All rights reserved.

    OpenPayer is built and maintained by Trek Health.

    v1.0.30
    OpenPayerBilling CodesCellular Regeneration, Evaluation Study and Ablation ProceduresCPT cpt-0489t-autologous-adipose-regenerative-cell-therapy-scleroderma-hands
    Ask Trek AI about this page

    CPT 0489T: Autologous Adipose-Derived Cell Therapy for Scleroderma of the Hands

    CPT code 0489T describes an autologous adipose-derived regenerative cell procedure in which the provider harvests the patient’s own fat cells, processes them to concentrate and dilute regenerative cells, and returns the cellular preparation for treatment of scleroderma of the hands; service type: autologous cell processing and injection/implantation, typical site of service: operating room or procedure suite (outpatient surgical setting).

    For related coverage guidance, see recent payer policy updates: Mohs Micrographic Surgery, Mohs Micrographic Surgery, Mohs Micrographic Surgery.

    Customize your policy alerts

    Sign up for cpt 0489T policy alerts

    Get alerted when payer policies referencing 0489T are released or updated.

    Monitor payer policy activity

    Receive email alerts as soon as relevant payer policies are published or updated.

    Table of contents

    Progress1 / 7

    Explore openpayer tools

    • Billing CodesCPT, HCPCS, DRG & more
    • Reimbursement RatesCommercial vs. Medicare rate reports
    • Facility ComparisonBeds, revenue & payer mix
    • ProvidersHospitals & facilities
    • PayersPlans & market footprint
    • Taxonomy CodesNUCC specialty codes
    • ModifiersCPT modifiers & usage
    • Prior AuthorizationPA policies by payer & drug
    • Timely FilingFiling deadlines by payer
    • Coverage CriteriaMedical necessity by payer
    • Payer ContactsClaims, PA & appeals contacts
    View all tools

    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult with localized scleroderma (systemic sclerosis with prominent hand involvement) who experiences painful digital ulcers, thickened skin, reduced hand range of motion, and impaired function despite optimized medical therapy. The multidisciplinary team includes a rheumatologist and a hand surgeon or plastic surgeon with experience in regenerative treatments. The patient presents to an ambulatory surgery center or outpatient procedure suite after pre-procedure evaluation confirms suitability for autologous adipose-derived cell therapy.

    The clinical workflow: the patient receives informed consent and pre-procedure optimization, including assessment of coagulation status and medication reconciliation. In the procedure suite, tumescent liposuction is performed to harvest autologous adipose tissue (usually from the abdomen or flanks). The harvested fat is processed using mechanical and/or enzymatic methods per device/clinic protocol to concentrate regenerative cell populations and achieve a specified dilution/concentration. The processed adipose-derived regenerative cell suspension is then injected into affected areas of the hands (e.g., subcutaneous and peri-lesional injections around digital ulcerations and sclerotic bands) under sterile conditions, often with local or monitored anesthesia care. Post-procedure monitoring includes vital sign observation, wound care of the donor and injection sites, hand therapy referral as needed, and follow-up visits to assess pain, wound healing, range of motion, and adverse events.

    Typical site of service: outpatient ambulatory surgery center or hospital outpatient department. Service type: autologous adipose-derived regenerative cell harvest, processing, and reimplantation for treatment of scleroderma of the hands. Typical patient scenario: adult with refractory scleroderma-related hand dysfunction and ischemic digital ulcers who has failed conventional medical and local wound therapies and is enrolled in clinic protocol or offered an off-label regenerative procedure.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    15771Dermal fat graft; single plane (separate procedure), includes obtaining graftMay be used for soft tissue augmentation in hand reconstruction and is related conceptually to adipose tissue transfer though technique differs from 0489T.
    20926Tissue grafts, other than autograft, includes obtaining graft (eg, dermal, fascial)Occasionally used for soft tissue defect management in the hand alongside regenerative treatments; distinct from autologous cell processing in 0489T.
    01810Anesthesia for procedures on the fingers, including digital blockOften billed when regional or digital block anesthesia is used during hand injections associated with 0489T.
    0350TProcessing of harvested adipose tissue, with concentrated cells returned to patientRepresents processing steps analogous to those described in 0489T and may be used in facilities with discrete device-dependent processing codes.
    99024Postoperative follow-up visit, after surgery (global period)

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    207RH0000X
    207RG0100X
    2084P0800X
    207T00000X
    1041S0200X
    3336M0002X
    175T00000X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    E11.9Type 2 diabetes mellitus without complications
    E83.51Hypocalcemia
    I73.9Peripheral vascular disease, unspecified
    I77.1Stricture of artery
    I83.90Asymptomatic varicose veins of unspecified lower extremity
    K64.9Unspecified hemorrhoids
    L94.0Localized scleroderma [morphea]
    L98.9Disorder of the skin and subcutaneous tissue, unspecified
    M05.79Rheumatoid arthritis with rheumatoid factor of multiple sites without organ or systems involvement
    M06.9Rheumatoid arthritis, unspecified

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Dermatology1 / 3

    10 rows

    PolicyPayerEffective Date
    Mohs Micrographic Surgerypremerabluecrossofwashington2027-02-05
    Mohs Micrographic Surgerypremerabluecrossofwashington2027-02-05
    Mohs Micrographic Surgerypremerabluecrossofwashington2027-02-05
    FilsuvezCigna2026-11-01
    Destruction of Pre-Malignant Skin LesionsAnthem2026-10-01
    Onychomycosis diagnostic testing and coverageOscar Health2026-10-01
    Treatment of Capillary Malformations (Port Wine Stains)universityofutahhealthplans2026-09-28
    AnzupgoCigna2026-09-15
    Hyperhidrosispriority_health_medicare2026-09-01
    Zevaskyn Coverage for Recessive Dystrophic Epidermolysis BullosaCigna2026-09-01

    Related Codes

    CPT-0490T-AUTOLOGOUS-ADIPOSE-REGENERATIVE-CELLS-FOR-HAND-SCLERODERMA

    CPT 0490T: Autologous Adipose-Derived Regenerative Cell Injection for Scleroderma

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
    Published by

    Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

    Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

    Used for routine postoperative follow-up visits after 0489T when payers require separate reporting of postoperative care.