CPT code 0488U is a Proprietary Laboratory Analyses (PLA) code for the Unity Fetal Antigen™ noninvasive prenatal test (NIPT) from BillionToOne Laboratory that uses cell-free DNA sequencing to detect fetal antigens (Rh, C, c, D, E, Duffy [Fya], and Kell [K]) in maternal blood to identify pregnancies at risk from maternal alloimmunization and guide monitoring for hemolytic disease of the fetus and newborn; service type: laboratory molecular diagnostic testing; typical site of service: outpatient laboratory or prenatal clinic with blood draw.

For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, Genomic Profiling for Selecting Targeted Cancer Therapies.