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CPT 0462U: Salivary Melatonin Profile (Circadian Phase Assessment)

CPT code 0462U designates a Proprietary Laboratory Analyses (PLA) test for the Salimetrics® Salivary Melatonin Profile (Circadian Phase Assessment), a specialized ELISA-based assay that creates a melatonin profile from seven or nine saliva samples and may include cortisol. This PLA code identifies a single manufacturer-specific test used to assess circadian phase and sleep-wake biology. Nationally, PLA codes like 0462U matter because they standardize reporting for unique commercial assays and influence lab billing, coverage reviews, and claims adjudication for novel diagnostics.

Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find an overview of clinical context for salivary melatonin profiling, guidance on where the service is typically performed, and the practical implications of a PLA-designated CPT code for billing workflows and payer communications. The publication covers benchmarks and reimbursement context where available, common billing and documentation considerations for proprietary assays, and relevant policy updates affecting laboratory diagnostics and PLA codes. Data not available in the input will be explicitly noted in specific sections.

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Billing Code Overview

CPT code 0462U is a Proprietary Laboratory Analyses (PLA) code reported exclusively for the Salimetrics® Salivary Melatonin Profile (Circadian Phase Assessment) from Salimetrics® LLC. The test produces a melatonin profile from either seven or nine salivary samples and may include cortisol. The assay method is enzyme–linked immunosorbent assay (ELISA). Melatonin measurements are used to assess circadian phase and are associated with sleep and wakefulness.

Service type: Proprietary laboratory diagnostic assay (salivary hormone profiling)
Typical site of service: Clinical laboratory or specialized diagnostic laboratory; specimen collection typically occurs in outpatient or home settings with subsequent laboratory processing.

Data not available in the input.

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CPT 0462U: Salivary Melatonin Profile (Circadian Phase Assessment)

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Sign up for cpt 0462U policy alerts

Get alerted when payer policies referencing 0462U are released or updated.

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Billing Code Overview

Service type: Proprietary laboratory diagnostic assay (salivary hormone profiling)
Typical site of service: Clinical laboratory or specialized diagnostic laboratory; specimen collection typically occurs in outpatient or home settings with subsequent laboratory processing.

Data not available in the input.

Clinical & Coding Specifications

Clinical Context

A typical patient is an adult or adolescent referred for evaluation of suspected circadian rhythm sleep–wake disorder, unexplained insomnia, excessive daytime sleepiness, or shift work-related sleep disruption. A primary care physician, sleep medicine specialist, or pediatrician orders the Salimetrics® Salivary Melatonin Profile (0462U) when assessment of endogenous melatonin secretion timing is needed to determine circadian phase or to guide timed melatonin therapy. The patient collects multiple saliva samples at home (seven or nine timed collections) across an evening and night period per the laboratory kit instructions. The specimen is returned to the performing laboratory (Salimetrics®) where the enzyme–linked immunosorbent assay (ELISA) is run to generate a melatonin concentration profile, optionally with cortisol if included. Results are reviewed by the ordering clinician to correlate melatonin onset/offset with reported sleep patterns and to inform treatment planning such as chronotherapy, light therapy scheduling, or medication timing. Typical site of service is an outpatient clinic, specialty sleep center, or home collection with laboratory processing; specimens are analyzed in a reference or proprietary central laboratory.

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	When reporting only the physician or professional interpretation component separate from the laboratory technical processing (rare for PLA tests when split billing is allowed).
`TC`	Technical component	When reporting only the laboratory technical component; used if professional interpretation is billed separately.
`QK`	CLIA waived test performed at point of care by laboratory certified under CLIA	If a performing site meets conditions and reports technical component under the CLIA pathway (unlikely for this PLA but included from provided list).
`QX`	Service performed by an auxiliary (e.g., non-physician practitioner) under physician supervision	When the specimen handling or test ordering is performed by auxiliary staff under supervision as allowed by payer rules.
`QY`	POCT certification exception	When point-of-care testing meets state licensure exemptions per payer guidance (seldom applicable to proprietary centralized assays).
`52`	Reduced services	When fewer samples or an abbreviated panel is processed than originally planned (e.g., fewer collection timepoints completed).
`53`	Discontinued procedure	If testing cannot be completed due to collection failure and the claim reflects a discontinued attempt.
`78`	Unplanned return to operating/procedure room by the same physician/other after initial procedure	Rare; included for completeness when an unplanned repeat specimen collection procedure occurs under the same encounter.
`80`	Assistant surgeon	Not typically applicable but used when an assisting provider performed technical aspects during an in-facility collection procedure.
`62`	Two surgeons	Rarely applicable; used when two providers share responsibility for an invasive specimen collection during the encounter.

Taxonomy Code	Specialty	Notes
207R00000X	Sleep Medicine	Clinicians who commonly order circadian assessments and interpret melatonin profiles.
207L00000X	Pulmonary Disease (Sleep Medicine)	Pulmonologists with sleep specialty involvement in sleep disorder diagnosis and management.
208D00000X	Pediatrics	Pediatricians managing delayed sleep phase or other circadian disorders in adolescents.
207S00000X	Neurology	Neurologists involved when neurologic causes of sleep–wake disturbance are being evaluated.
363L00000X	Clinical Laboratory	Laboratory directors and technologists responsible for performing the ELISA analysis in the reference lab.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`G47.20`	Circadian rhythm sleep disorder, unspecified	Frequently used when assessing circadian phase with melatonin profiling to evaluate timing of endogenous melatonin secretion.
`G47.00`	Insomnia, unspecified	Melatonin profiling may help differentiate circadian-driven insomnia from other causes.
`G47.33`	Obstructive sleep apnea (adult) (pediatric)	Used when sleep disruption from OSA coexists and clinicians evaluate circadian contribution; melatonin testing may be adjunctive.
`F51.11`	Delayed sleep phase disorder	Directly related—melatonin profile documents delayed dim light melatonin onset supporting diagnosis.
`Z72.82`	Shift work sleep disorder	Melatonin profiling helps assess circadian misalignment in shift workers to guide timing interventions.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`0362U`	Proprietary Laboratory Analyses — (example PLA code) measurement of a salivary analyte (placeholder)	Other PLA codes for salivary or endocrine assays may be ordered alongside `0462U` when additional analytes are required.
`99000`	Handling and/or conveyance of a specimen for transport; e.g., courier service	Used when special specimen transport or courier services are billed in association with home-collected saliva kits sent to the central laboratory.
`99001`	Laboratory specimen handling (non-covered) — carrier/transport charge (example)	Administrative or non-covered charges related to specimen processing and kit management may be documented with facility-specific charges.
`84133`	Prolactin; quantitative	Example endocrine assay codes commonly ordered in endocrine workups; may be ordered in parallel panels in sleep-related endocrine assessment.
`84443`	Thyroid stimulating hormone (TSH)	TSH measurement is commonly ordered in evaluation of sleep disorders where hypothyroidism or other endocrine issues may contribute.

CPT 0001U: PreciseType HEA Multiplex Erythrocyte Antigen Assay

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: Urine Metabolomic Polyp Risk Assay (PolypDX™)

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa™ (OVA1 Next Generation) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) Urine Gene Expression Risk Test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen with DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Panel, Gene Sequence Analysis

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Cordant CORE™ Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcript Testing

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	When reporting only the physician or professional interpretation component separate from the laboratory technical processing (rare for PLA tests when split billing is allowed).
`TC`	Technical component	When reporting only the laboratory technical component; used if professional interpretation is billed separately.
`QK`	CLIA waived test performed at point of care by laboratory certified under CLIA	If a performing site meets conditions and reports technical component under the CLIA pathway (unlikely for this PLA but included from provided list).
`QX`	Service performed by an auxiliary (e.g., non-physician practitioner) under physician supervision	When the specimen handling or test ordering is performed by auxiliary staff under supervision as allowed by payer rules.
`QY`	POCT certification exception	When point-of-care testing meets state licensure exemptions per payer guidance (seldom applicable to proprietary centralized assays).
`52`	Reduced services	When fewer samples or an abbreviated panel is processed than originally planned (e.g., fewer collection timepoints completed).
`53`	Discontinued procedure	If testing cannot be completed due to collection failure and the claim reflects a discontinued attempt.
`78`	Unplanned return to operating/procedure room by the same physician/other after initial procedure	Rare; included for completeness when an unplanned repeat specimen collection procedure occurs under the same encounter.
`80`	Assistant surgeon	Not typically applicable but used when an assisting provider performed technical aspects during an in-facility collection procedure.
`62`	Two surgeons	Rarely applicable; used when two providers share responsibility for an invasive specimen collection during the encounter.

Taxonomy Code	Specialty	Notes
207R00000X	Sleep Medicine	Clinicians who commonly order circadian assessments and interpret melatonin profiles.
207L00000X	Pulmonary Disease (Sleep Medicine)	Pulmonologists with sleep specialty involvement in sleep disorder diagnosis and management.
208D00000X	Pediatrics	Pediatricians managing delayed sleep phase or other circadian disorders in adolescents.
207S00000X	Neurology	Neurologists involved when neurologic causes of sleep–wake disturbance are being evaluated.
363L00000X	Clinical Laboratory	Laboratory directors and technologists responsible for performing the ELISA analysis in the reference lab.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`G47.20`	Circadian rhythm sleep disorder, unspecified	Frequently used when assessing circadian phase with melatonin profiling to evaluate timing of endogenous melatonin secretion.
`G47.00`	Insomnia, unspecified	Melatonin profiling may help differentiate circadian-driven insomnia from other causes.
`G47.33`	Obstructive sleep apnea (adult) (pediatric)	Used when sleep disruption from OSA coexists and clinicians evaluate circadian contribution; melatonin testing may be adjunctive.
`F51.11`	Delayed sleep phase disorder	Directly related—melatonin profile documents delayed dim light melatonin onset supporting diagnosis.
`Z72.82`	Shift work sleep disorder	Melatonin profiling helps assess circadian misalignment in shift workers to guide timing interventions.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`0362U`	Proprietary Laboratory Analyses — (example PLA code) measurement of a salivary analyte (placeholder)	Other PLA codes for salivary or endocrine assays may be ordered alongside `0462U` when additional analytes are required.
`99000`	Handling and/or conveyance of a specimen for transport; e.g., courier service	Used when special specimen transport or courier services are billed in association with home-collected saliva kits sent to the central laboratory.
`99001`	Laboratory specimen handling (non-covered) — carrier/transport charge (example)	Administrative or non-covered charges related to specimen processing and kit management may be documented with facility-specific charges.
`84133`	Prolactin; quantitative	Example endocrine assay codes commonly ordered in endocrine workups; may be ordered in parallel panels in sleep-related endocrine assessment.
`84443`	Thyroid stimulating hormone (TSH)	TSH measurement is commonly ordered in evaluation of sleep disorders where hypothyroidism or other endocrine issues may contribute.

CPT 0001U: PreciseType HEA Multiplex Erythrocyte Antigen Assay

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: Urine Metabolomic Polyp Risk Assay (PolypDX™)

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa™ (OVA1 Next Generation) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) Urine Gene Expression Risk Test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen with DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Panel, Gene Sequence Analysis

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Cordant CORE™ Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcript Testing

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

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CPT 0462U: Salivary Melatonin Profile (Circadian Phase Assessment)

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Billing Code Overview

OpenPayer

CPT 0462U: Salivary Melatonin Profile (Circadian Phase Assessment)

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Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

CPT 0462U: Salivary Melatonin Profile (Circadian Phase Assessment)

Sign up for cpt 0462U policy alerts

Billing Code Overview

CPT 0462U: Salivary Melatonin Profile (Circadian Phase Assessment)

Sign up for cpt 0462U policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What exactly does CPT 0462U represent?

In which clinical scenarios and by which clinicians is the Salimetrics® Salivary Melatonin Profile usually ordered?

Where and how are samples for 0462U collected and processed?

Which billing modifiers might be relevant when submitting claims for 0462U?

Which payers are referenced and does the page provide reimbursement rates for 0462U?

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What exactly does CPT 0462U represent?

In which clinical scenarios and by which clinicians is the Salimetrics® Salivary Melatonin Profile usually ordered?

Where and how are samples for 0462U collected and processed?

Which billing modifiers might be relevant when submitting claims for 0462U?

Which payers are referenced and does the page provide reimbursement rates for 0462U?

References