Summary & Overview
CPT 0460U: RightMed Oncology Gene Report, 24-Gene SNP Genotyping
CPT code 0460U designates the RightMed® Oncology Gene Report from OneOme® LLC, a proprietary laboratory test that performs DNA single–nucleotide polymorphism (SNP) genotyping across 24 genes using whole blood or buccal swab specimens and reports phenotype interpretations. As a PLA code, 0460U applies only to this specific manufacturer's assay and is used to identify genetic variants and inferred phenotypes with potential relevance to oncology pharmacogenomics and therapeutic decision-making. Nationally, PLA codes like 0460U matter because they enable capture of proprietary molecular testing distinct from non-proprietary panels, and they inform coverage, billing, and comparative utilization discussions.
Key payers considered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the clinical and billing context for the assay, payer coverage considerations, common claim modifiers, and where the test is typically performed. The publication also summarizes benchmark topics and policy implications relevant to proprietary genetic testing, including coding specificity, site-of-service considerations, and the role of PLA codes in claims processing. Data not available in the input will be noted where applicable.
Billing Code Overview
CPT code 0460U is a Proprietary Laboratory Analyses (PLA) code that applies exclusively to the RightMed® Oncology Gene Report from OneOme® LLC. The test uses a whole blood or buccal (cheek) swab specimen and performs DNA single–nucleotide polymorphism (SNP) genotyping of 24 genes to identify nucleotide variations. The report includes phenotype interpretations derived from the genotyping results, providing observable-trait information relevant to oncology pharmacogenomics and related clinical decision support.
Service Type: Genetic/SNP genotyping laboratory test (proprietary PLA test)
Typical Site of Service: Clinical laboratory or independent diagnostic testing facility (specimen collected in ambulatory settings or sent from clinic to laboratory)
Clinical & Coding Specifications
Clinical Context
A typical patient is an adult oncology patient preparing for systemic cancer therapy where medication selection and dosing may be influenced by germline pharmacogenomic variants. The clinician orders the RightMed® Oncology Gene Report (0460U) from OneOme® LLC when reviewing medication-related risk for chemotherapy agents, targeted therapies, supportive care medications (e.g., antiemetics, analgesics), or when a history of unusual drug toxicity or treatment failure suggests pharmacogenomic contribution. A sample (whole blood or buccal swab) is collected during an outpatient oncology clinic visit or at a phlebotomy laboratory. The specimen is sent to the performing laboratory. Results report SNP genotypes across 24 genes and derived phenotypes (e.g., poor, intermediate, normal, rapid metabolizer) and are reviewed by the treating oncologist, pharmacist, or genetics team to inform drug selection, dose adjustments, and clinical monitoring. Typical sites of service include outpatient hospital clinics, ambulatory surgery centers for ancillary testing coordination, independent phlebotomy laboratories, and physician office laboratories. Common clinical workflow steps: order placement in the electronic health record, specimen collection and shipment, laboratory genotyping and analysis, report release into the chart, and clinician review with documentation of any medication management decisions.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
00 | No modifier — standard submission |