CPT code 0412U is a Proprietary Laboratory Analyses (PLA) code reported only for the PrecivityAD® blood test from C2N Diagnostics LLC; using liquid chromatography–tandem mass spectrometry (LC–MS/MS) on a plasma specimen, the assay measures beta amyloid 40 and 42 levels and determines apolipoprotein E (ApoE) phenotype, and an algorithmic analysis produces a probability score for cerebral amyloid plaque consistent with Alzheimer’s disease, reported as a laboratory diagnostic test typically ordered and performed in clinical laboratory settings (phlebotomy site for specimen collection, reference or specialty lab for analysis).

For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, Genomic Profiling for Selecting Targeted Cancer Therapies.