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    v1.0.28
    OpenPayerBilling CodesProcedures performed on CorneaCPT cpt-0402t-corneal-collagen-crosslinking-riboflavin-uv
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    CPT 0402T: Corneal Collagen Crosslinking with Riboflavin (UV)

    CPT code 0402T describes corneal collagen crosslinking using riboflavin (vitamin B2) eyedrops activated by ultraviolet light to strengthen and stiffen the cornea; the service typically involves removal of the corneal epithelium as needed and intraoperative pachymetry to measure corneal thickness. This procedure is an ophthalmic therapeutic intervention (corneal strengthening/crosslinking) usually performed in an ambulatory surgical center or ophthalmology clinic procedure room under topical or local anesthesia and billed as a procedural ophthalmology service.

    For related coverage guidance, see recent payer policy updates: Evaluation of Dry Eyes, Evaluation of Dry Eyes, Ophthalmic Prostaglandin Analog Prior Authorization Criteria.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adolescent or young adult presenting to an ophthalmology clinic with progressive keratoconus or post-refractive ectasia causing visual distortion and decreasing contact lens tolerance. The clinical workflow begins with diagnostic evaluation including manifest refraction, slit-lamp examination, corneal topography/tomography and pachymetry to document corneal thinning and irregular astigmatism. After conservative measures (rigid gas permeable lenses or scleral lenses) are considered, the surgeon discusses corneal collagen cross-linking using riboflavin (vitamin B2) with ultraviolet-A activation to stiffen the cornea.

    On the procedure day the patient arrives to an ambulatory surgery center or ophthalmology clinic procedure room. Topical anesthesia is applied; the surgeon may remove the central corneal epithelium (epithelium-off technique) or leave it intact (epithelium-on) per protocol. Pachymetry is used intraoperatively to confirm safe corneal thickness; supplemental riboflavin drops are instilled to saturate the stroma. Ultraviolet-A light is applied to activate the riboflavin, inducing crosslinking. Post-procedure care includes topical antibiotics, cycloplegia as needed, and a bandage contact lens if epithelium was removed. Follow-up visits include recheck of pain, epithelial healing, corneal clarity, and serial topography to document stabilization of ectatic progression.

    Typical site of service: ambulatory surgery center or ophthalmology clinic procedure room. Service type: ophthalmic therapeutic procedure (corneal collagen cross-linking) with intraoperative pachymetry and possible epithelial removal.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    92250Fundus photography with interpretation and reportBaseline and follow-up imaging for documentation of ocular status; not specific to cornea but part of comprehensive records.
    92132Scanning computerized ophthalmic diagnostic imaging, posterior segment, with interpretationUsed for baseline retinal assessment when comprehensive ocular evaluation is performed prior to cross-linking.
    92083Visual field examination, extendedPerformed when broader functional assessment of vision is needed in preoperative evaluation.
    92100Serial tonometry and tonographyIntraocular pressure checks may be performed pre- and post-procedure to monitor ocular health.
    99173Screening test of visual acuity, quantitative, bilateralBasic visual acuity assessment used in pre- and postoperative visits.
    76514Corneal topography, videokeratography, unilateral or bilateralEssential diagnostic test to document keratoconus extent and to monitor response to cross-linking.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207W00000XOphthalmology PhysicianAn ophthalmologist has the knowledge and professional skills needed to provide comprehensive eye and vision care. Ophthalmologists are medically train…
    363LA2200XAdult Health Nurse PractitionerPhysician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    2084H0002XHospice and Palliative Medicine (Psychiatry & Neurology) PhysicianA psychiatrist or neurologist with special knowledge and skills to prevent and relieve the suffering experienced by patients with life-limiting illnes…
    2085R0203XTherapeutic Radiology PhysicianTherapeutic Radiology certificate name was changed to Radiation Oncology. Use Radiation Oncology.
    364SC0200XCritical Care Medicine Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    246ZC0007XSurgical AssistantA surgical assistant is a skilled practitioner who has undergone formalized education and training as a surgical assistant. The surgical assistant per…

    Related ICD-10-CM Codes

    13 rows

    ICD-10-CM CodeDescription
    H16.221Keratoconjunctivitis sicca, not specified as Sjogren's, right eye
    H16.222Keratoconjunctivitis sicca, not specified as Sjogren's, left eye
    H16.223Keratoconjunctivitis sicca, not specified as Sjogren's, bilateral
    H18.43Other calcerous corneal degeneration
    H18.49Other corneal degeneration
    H18.839Recurrent erosion of cornea, unspecified eye
    H18.9Unspecified disorder of cornea
    H25.9Unspecified age-related cataract
    H26.9Unspecified cataract
    H43.9Unspecified disorder of vitreous body

    Showing 1–10 of 13

    Related Payer Policy Updates

    Specialty: Ophthalmology/Optometry1 / 2

    4 rows

    PolicyPayerEffective Date
    Evaluation of Dry EyesOscar Health2026-10-01
    Evaluation of Dry EyesBlue Cross Blue Shield - New Mexico2026-09-04
    Ophthalmic Prostaglandin Analog Prior Authorization Criteriamedimpact2026-09-01
    revakinagene taroretcel-lwey (Encelto) coverage for idiopathic macular telangiectasia (MacTel) type 2blue cross blue shield - louisiana2026-09-01

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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