CPT code 0400U designates the Genesys Carrier Panel, a Proprietary Laboratory Analyses (PLA) test that screens 145 genes from blood or buccal swab specimens to identify carrier variants for rare inherited disorders, including cystic fibrosis. As a PLA code, 0400U applies exclusively to a single manufacturer's assay and signals a highly specific genomic service with implications for reproductive planning and genetic counseling. Nationally, such panels are increasingly relevant as carrier screening expands in preconception and prenatal care.

Key payers in scope include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the clinical purpose of the panel, expected service setting, and which major payers are discussed. The publication also covers benchmark considerations for billing and coverage, policy and coding updates affecting PLA codes, and clinical context for when a 145-gene carrier screen may be used.

This summary is intended for health plan analysts, billing managers, laboratory administrators, and clinicians seeking a national briefing on the coding and payer landscape for this specific genetic carrier screening test.