Summary & Overview
CPT 0394U: PFAS Testing & PFASure™ Serum/Plasma LC–MS/MS
CPT code 0394U designates a Proprietary Laboratory Analyses (PLA) test — PFAS Testing & PFASure™ from National Medical Services, NMS Labs Inc. The assay quantifies 16 perfluoroalkyl substances (PFAS) in serum or plasma using LC–MS/MS, and is used in clinical and environmental exposure assessments. As a PLA code, 0394U applies uniquely to this manufacturer’s test and is relevant for clinicians, laboratories, and payers managing PFAS-related diagnostic requests nationwide.
Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context for PFAS biomonitoring, where the service is typically performed, and payer coverage landscape. The publication summarizes benchmarks for utilization and reimbursement where available, highlights coding and billing considerations tied to PLA status, and outlines policy and coverage themes that affect access to specialized PFAS testing across commercial and public payers.
This summary is intended to inform stakeholders about the function and significance of CPT code 0394U, how it is used in practice for PFAS exposure evaluation, and what topics to expect in the full analysis, including payer approaches, billing guidance, and clinical applicability.
Billing Code Overview
CPT code 0394U is a Proprietary Laboratory Analyses (PLA) code for PFAS Testing & PFASure™ performed by National Medical Services, NMS Labs Inc. The test measures the levels of 16 perfluoroalkyl substances (PFAS) compounds in a serum or plasma specimen using liquid chromatography with tandem mass spectrometry (LC–MS/MS).
-
Service type: Commercial laboratory diagnostic testing for environmental/toxicology exposure assessment
-
Typical site of service: Clinical laboratory or specialized reference lab (specimen collected in outpatient phlebotomy or clinical setting and sent to the performing laboratory)
Clinical & Coding Specifications
Clinical Context
A typical patient is an adult or pediatric patient with documented or suspected exposure to per- and polyfluoroalkyl substances (PFAS) from an environmental source (contaminated drinking water, occupational exposure, firefighting foam, or nearby industrial release). The patient presents to an outpatient specialty clinic (occupational medicine, environmental health, toxicology, or primary care) requesting confirmatory serum testing after exposure history and counseling. The clinician orders PFAS quantitative serum testing using the PFASure™ panel performed by NMS Labs (Proprietary Laboratory Analysis 0394U). A phlebotomy visit is scheduled at an outpatient laboratory or hospital outpatient draw station. A serum or plasma specimen is collected, processed, and shipped under chain-of-custody and stability requirements to the performing laboratory. Results report concentrations of 16 PFAS compounds measured by liquid chromatography–tandem mass spectrometry (LC–MS/MS). Reported values inform exposure assessment, patient counseling, occupational case management, or public health reporting. Typical sites of service include outpatient laboratory draw sites, hospital outpatient phlebotomy, occupational health clinics, and outpatient specialty clinics. Follow-up actions (clinical interpretation, additional testing, or public health notification) occur in outpatient or consultative visits after results are returned.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
00 |