Summary & Overview
CPT 0392U: Medication Management Neuropsychiatric Pharmacogenomic Panel
CPT code 0392U designates a Proprietary Laboratory Analyses (PLA) test — the Medication Management Neuropsychiatric Panel by RCA Laboratory Services LLC d/b/a GENETWORx. The assay uses a buccal swab for targeted sequencing of 16 genes and CYP2D6 copy-number analysis to report gene–drug interaction impacts for psychiatric medications. This code matters nationally as precision prescribing and pharmacogenomics grow in mental health care, influencing medication selection and adverse event risk mitigation.
Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the test’s clinical purpose and service setting, typical payer coverage landscape, and the types of benchmarks and policy considerations commonly relevant to PLA pharmacogenomic codes. The publication covers coverage patterns and reimbursement considerations for proprietary lab tests, coding nuances for PLA entries, and clinical context for use in medication management for neuropsychiatric conditions. Data not available in the input for specific coverage determinations, associated taxonomies, and ICD-10 mappings will be noted where applicable.
Billing Code Overview
CPT code 0392U is a Proprietary Laboratory Analyses (PLA) code that applies to a single, specific laboratory test: the Medication Management Neuropsychiatric Panel performed by RCA Laboratory Services LLC d/b/a GENETWORx. The test uses a buccal (cheek) swab specimen and performs targeted sequence analysis of 16 genes plus CYP2D6 duplication/deletion analysis. Results report the impact of gene–drug interactions for individual psychiatric medications based on the patient’s genetics and other relevant factors.
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Service type: Genetic testing; pharmacogenomic medication management panel
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Typical site of service: Clinical laboratory using buccal swab specimen collection (ambulatory clinic, outpatient collection site, or specialized phlebotomy/collection center)
Clinical & Coding Specifications
Clinical Context
A 34-year-old outpatient with a history of major depressive disorder and partial response to selective serotonin reuptake inhibitors presents to a psychiatric clinic for medication optimization. The treating psychiatrist orders the Medication Management Neuropsychiatric Panel (0392U) from RCA Laboratory Services LLC d/b/a GENETWORx to inform psychotropic selection and dosing. A buccal swab is collected in clinic or at an affiliated phlebotomy site; the specimen is sent to the performing lab for targeted sequence analysis of 16 pharmacogenes plus CYP2D6 duplication/deletion analysis. The laboratory report returns genotype-based drug–gene interaction interpretations and actionable guidance on drug selection and dosing for psychiatric medications. The clinical workflow includes: patient consent for genetic testing, collection of a buccal swab, completion of laboratory requisition with clinical indication, specimen shipment to GENETWORx, result review by the ordering clinician, and documentation of results and resultant medication management decisions in the medical record.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
00 | Default professional and technical component globally billed | Use when no specific component modifier applies and the service is billed normally by a single entity. |