CPT code 0309U is a Proprietary Laboratory Analyses (PLA) code specific to the HART CVE® test from Prevencio Inc.; it represents a laboratory assay that measures levels of four specified plasma proteins and applies an algorithmic analysis to generate a risk score for major adverse cardiovascular events (such as heart attack or stroke). The service is a laboratory-based diagnostic risk assessment performed on a patient plasma specimen, typically provided in a clinical laboratory or outpatient phlebotomy setting, and reported using the designated PLA CPT code 0309U.

For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, Genomic Profiling for Selecting Targeted Cancer Therapies.