CPT 0300U: Combined Whole Genome Sequencing and Optical Genome Mapping
CPT code 0300U designates a proprietary laboratory test — Praxis Somatic Combined Whole Genome Sequencing and Optical Genome Mapping — that pairs next‑generation whole genome sequencing with optical genome mapping to detect both sequence variants and structural rearrangements in paired normal and tumor specimens. This hybrid approach is intended to improve genomic characterization of cancer samples and support diagnostic and therapeutic decision making at a national level. Major payers included in this analysis are Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise explanation of the clinical and technical scope of the test, the typical sites of service, and which payers are evaluated. The publication summarizes payer coverage approaches and benchmarks, highlights relevant policy updates affecting proprietary PLA codes, and provides clinical context for when combined WGS and OGM may be used. Where payer-specific policy details or additional billing elements are unavailable, the report notes that data are not available in the input. The goal is to inform billing, coding, and policy stakeholders about the role of CPT code 0300U in genomic oncology testing and payer coverage landscapes.
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Billing Code Overview
CPT code 0300U is a Proprietary Laboratory Analyses (PLA) code that applies to a single, manufacturer‑specific laboratory test: Praxis Somatic Combined Whole Genome Sequencing and Optical Genome Mapping from Praxis Genomics LLC. The test evaluates paired normal and malignant (tumor) specimens from the patient, such as blood, bone marrow, or frozen tissue. The procedure combines whole genome sequencing (WGS) via next‑generation sequencing (NGS) and optical genome mapping (OGM) to identify sequence-level and structural genomic variants that can inform diagnosis and treatment of various cancers.
Service type: Laboratory — combined molecular genomic sequencing and optical genome mapping.
Typical site of service: Clinical laboratory or specialized molecular diagnostics laboratory processing specimens collected from inpatient or outpatient settings; specimen sources include blood, bone marrow, or frozen tissue.