Summary & Overview
CPT 0299U: Somatic Optical Genome Mapping for Tumor Structural Variant Analysis
CPT code 0299U designates the Praxis Somatic Optical Genome Mapping test, a Proprietary Laboratory Analyses (PLA) assay that compares paired normal and malignant specimens to detect large-scale structural DNA changes associated with cancer. As a PLA code tied to a single manufacturer's assay, 0299U matters nationally because it enables specific reporting and tracking of a novel optical genome mapping (OGM) technology that may influence diagnostic pathways for hematologic and solid tumor evaluation.
Key payers covered in the analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the clinical purpose of the test, typical sites of service, and the service type. The publication presents benchmarks and coverage policy context where available, summarizes payer approaches to PLA and emerging genomic technologies, and outlines clinical considerations relevant to oncology diagnostic workflows.
This report is intended for national audiences of payers, providers, and laboratory administrators seeking clarity on billing, coding, and the clinical role of a proprietary OGM-based somatic test. Data not available in the input is noted where applicable.
Billing Code Overview
CPT code 0299U is a Proprietary Laboratory Analyses (PLA) code for the Praxis Somatic Optical Genome Mapping test from Praxis Genomics LLC. The test evaluates paired normal and malignant (tumor) specimens from the patient — for example, blood, bone marrow, or frozen tissue — to identify structural changes in large segments of DNA that may be associated with cancer.
Service type: Laboratory — somatic tumor genomic structural variation analysis using optical genome mapping
Typical site of service: Clinical laboratory or specialized molecular diagnostics laboratory
Data not available in the input for associated taxonomies, ICD-10 diagnoses, and related codes.
Clinical & Coding Specifications
Clinical Context
A 62-year-old patient with newly diagnosed acute myeloid leukemia (AML) undergoes collection of paired specimens—peripheral blood and a bone marrow aspirate—to characterize large structural genomic abnormalities. The oncology team orders the Praxis Somatic Optical Genome Mapping test (0299U) to compare the patient’s normal (peripheral blood) and malignant (bone marrow) DNA using optical genome mapping. Specimens are processed per the laboratory’s instructions: fresh or frozen tissue is shipped to the reference laboratory, where the proprietary assay analyzes large chromosomal rearrangements, copy number changes, and complex repetitive or rearranged DNA regions that may inform prognosis, identify actionable structural variants, and guide selection of targeted therapies or enrollment in clinical trials. Typical workflow: clinician documents indication in the medical record and obtains informed consent; samples are collected in the hospital outpatient infusion center or inpatient unit; specimen accessioning and courier shipment to Praxis Genomics LLC; laboratory performs OGM and issues a report to the ordering oncologist; results are integrated into multidisciplinary tumor board or treatment planning. Typical sites of service include hospital inpatient, hospital outpatient, and independent reference laboratory settings.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
00 | No modifier; full global service | Use when no unusual circumstances modify the service. |