CPT 0298U: Praxis Somatic Transcriptome, Molecular Diagnostic

CPT code 0298U designates the Praxis Somatic Transcriptome, a proprietary laboratory assay by Praxis Genomics LLC that measures gene expression differences between paired normal and malignant patient specimens (blood, bone marrow, or FFPE/fresh tissue) to assess the functional impact of previously identified DNA mutations. As a PLA code, 0298U is unique to a single manufacturer's test and is used in billing to identify this specific molecular diagnostic service. Nationally, PLA codes matter because they standardize reporting for unique commercial tests and affect coverage and payment pathways for advanced diagnostics.

Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the clinical intent of the test, expected settings for service delivery, and the payers commonly involved in coverage decisions. The publication summarizes typical billing characteristics for proprietary molecular assays, common modifiers associated with laboratory services, and the clinical context in which the test is performed. Data not available in the input: associated taxonomies, ICD-10 diagnoses, related codes, and service-line financial benchmarks.

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Billing Code Overview

CPT code 0298U is a Proprietary Laboratory Analyses (PLA) code that applies exclusively to the Praxis Somatic Transcriptome test from Praxis Genomics LLC. The assay evaluates paired normal and malignant (tumor) specimens from the patient — such as blood, bone marrow, or fresh or formalin–fixed paraffin–embedded (FFPE) tissue — to assess gene expression (activity) changes related to previously identified DNA mutations and to gauge the functional impact of those genetic changes in the malignant specimen.

Service type: Molecular diagnostic / proprietary transcriptome analysis

Typical site of service: Clinical diagnostic laboratory

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CPT 0298U: Praxis Somatic Transcriptome, Molecular Diagnostic

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Get alerted when payer policies referencing 0298U are released or updated.

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Billing Code Overview

Service type: Molecular diagnostic / proprietary transcriptome analysis

Typical site of service: Clinical diagnostic laboratory

Clinical & Coding Specifications

Clinical Context

A 62-year-old patient with a history of metastatic colorectal adenocarcinoma undergoes surgical resection of a liver metastasis. Prior tumor DNA sequencing identified several somatic variants of uncertain functional impact. The treating oncologist orders the Praxis Somatic Transcriptome test to evaluate paired normal and malignant specimens (archived FFPE tumor tissue and a peripheral blood sample) to measure gene expression changes associated with the previously identified DNA mutations. The laboratory receives the specimens, performs RNA extraction and expression profiling, compares tumor versus matched normal expression, and generates a report describing functional consequences of the DNA alterations to assist oncologists and molecular tumor boards in therapy selection and clinical trial matching.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`C78.7`	Secondary malignant neoplasm of liver and intrahepatic bile duct	Metastatic liver lesion commonly biopsied/resected with tumor tissue used for paired transcriptome analysis.
`C18.9`	Malignant neoplasm of colon, unspecified	Primary colorectal cancers frequently undergo DNA and RNA testing for targeted therapy selection.
`C50.919`	Malignant neoplasm of unspecified site of right female breast	Primary breast cancers often require molecular profiling including transcriptome-level assessment for functional impact of mutations.
`C61`	Malignant neoplasm of prostate gland	Prostate cancers may undergo molecular testing when clinical management requires understanding variant function.
`C34.90`	Malignant neoplasm of unspecified part of unspecified bronchus or lung	Lung cancers commonly have DNA alterations where transcriptome testing can clarify functional consequences for treatment decisions.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`88305`	Level IV surgical pathology, gross and microscopic examination	Used for initial anatomic pathology evaluation and selection of tumor tissue blocks for molecular testing.
`81325`	BRAF (e.g., V600) mutation analysis by sequencing methods	Molecular DNA testing that may identify mutations for which the transcriptome test evaluates functional impact.
`81445`	Oncology (solid organ) multigene panel, sequencing of tumor DNA	Comprehensive tumor DNA panels often precede transcriptome testing to identify variants of interest that require functional assessment.
`86413`	Tumor marker immunoassay (e.g., CEA)	Ancillary tumor marker testing performed in oncology workup; not a substitute but commonly ordered in the same care episode.
`G0452`	Drug screen, qualitative; multiple classes	Often performed in pre-therapy evaluation or clinical trial screening processes in oncology care pathways.

Related Modifiers

9 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
55	Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…	- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207P00000X	Emergency Medicine Physician	An emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
246QH0600X	Histology Specialist/Technologist	Technologists, Technicians & Other Technical Service Providers · Specialist/Technologist, Pathology
207ZP0105X	Clinical Pathology/Laboratory Medicine Physician	A pathologist deals with the causes and nature of disease and contributes to diagnosis, prognosis and treatment through knowledge gained by the labora…
3747P1801X	Personal Care Attendant	An individual who provides assistance with eating, bathing, dressing, personal hygiene, activities of daily living as specified in the plan of care. …
163WF0300X	Flight Registered Nurse	Nursing Service Providers · Registered Nurse

CPT 0001U: PreciseType HEA Multiplex Erythrocyte Antigen Assay

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: Urine Metabolomic Polyp Risk Assay (PolypDX™)

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa™ (OVA1 Next Generation) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) Urine Gene Expression Risk Test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen with DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Panel, Gene Sequence Analysis

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Cordant CORE™ Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcript Testing

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`C78.7`	Secondary malignant neoplasm of liver and intrahepatic bile duct	Metastatic liver lesion commonly biopsied/resected with tumor tissue used for paired transcriptome analysis.
`C18.9`	Malignant neoplasm of colon, unspecified	Primary colorectal cancers frequently undergo DNA and RNA testing for targeted therapy selection.
`C50.919`	Malignant neoplasm of unspecified site of right female breast	Primary breast cancers often require molecular profiling including transcriptome-level assessment for functional impact of mutations.
`C61`	Malignant neoplasm of prostate gland	Prostate cancers may undergo molecular testing when clinical management requires understanding variant function.
`C34.90`	Malignant neoplasm of unspecified part of unspecified bronchus or lung	Lung cancers commonly have DNA alterations where transcriptome testing can clarify functional consequences for treatment decisions.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`88305`	Level IV surgical pathology, gross and microscopic examination	Used for initial anatomic pathology evaluation and selection of tumor tissue blocks for molecular testing.
`81325`	BRAF (e.g., V600) mutation analysis by sequencing methods	Molecular DNA testing that may identify mutations for which the transcriptome test evaluates functional impact.
`81445`	Oncology (solid organ) multigene panel, sequencing of tumor DNA	Comprehensive tumor DNA panels often precede transcriptome testing to identify variants of interest that require functional assessment.
`86413`	Tumor marker immunoassay (e.g., CEA)	Ancillary tumor marker testing performed in oncology workup; not a substitute but commonly ordered in the same care episode.
`G0452`	Drug screen, qualitative; multiple classes	Often performed in pre-therapy evaluation or clinical trial screening processes in oncology care pathways.

Related Modifiers

9 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
55	Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…	- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207P00000X	Emergency Medicine Physician	An emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
246QH0600X	Histology Specialist/Technologist	Technologists, Technicians & Other Technical Service Providers · Specialist/Technologist, Pathology
207ZP0105X	Clinical Pathology/Laboratory Medicine Physician	A pathologist deals with the causes and nature of disease and contributes to diagnosis, prognosis and treatment through knowledge gained by the labora…
3747P1801X	Personal Care Attendant	An individual who provides assistance with eating, bathing, dressing, personal hygiene, activities of daily living as specified in the plan of care. …
163WF0300X	Flight Registered Nurse	Nursing Service Providers · Registered Nurse

CPT 0001U: PreciseType HEA Multiplex Erythrocyte Antigen Assay

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: Urine Metabolomic Polyp Risk Assay (PolypDX™)

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa™ (OVA1 Next Generation) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) Urine Gene Expression Risk Test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen with DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Panel, Gene Sequence Analysis

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Cordant CORE™ Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcript Testing

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 0298U: Praxis Somatic Transcriptome, Molecular Diagnostic

Sign up for cpt 0298U policy alerts

Billing Code Overview

OpenPayer

CPT 0298U: Praxis Somatic Transcriptome, Molecular Diagnostic

Sign up for cpt 0298U policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

CPT 0298U: Praxis Somatic Transcriptome, Molecular Diagnostic

Sign up for cpt 0298U policy alerts

Billing Code Overview

CPT 0298U: Praxis Somatic Transcriptome, Molecular Diagnostic

Sign up for cpt 0298U policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT code 0298U represent?

What specimens and clinical purpose are described for the Praxis Somatic Transcriptome?

Which related CPT codes are relevant when ordering or billing 0298U?

Which modifiers are indicated for use with this test and when should they be applied?

Does the page provide coverage or reimbursement rates for 0298U?

References

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT code 0298U represent?

What specimens and clinical purpose are described for the Praxis Somatic Transcriptome?

Which related CPT codes are relevant when ordering or billing 0298U?

Which modifiers are indicated for use with this test and when should they be applied?

Does the page provide coverage or reimbursement rates for 0298U?

References