CPT code 0291U is a Proprietary Laboratory Analyses (PLA) code for the MindX Blood Test™ – Mood by MindX Sciences™ Inc., a laboratory-developed blood test that uses next-generation sequencing of RNA to measure expression of 144 genes and an algorithmic analysis to generate a predictive risk score for mood disorders such as depression and bipolar disorder; service type: laboratory molecular diagnostic test using NGS RNA gene expression profiling; typical site of service: clinical laboratory or reference diagnostic laboratory processing a patient blood specimen.

For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, Genomic Profiling for Selecting Targeted Cancer Therapies.