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    v1.0.28
    OpenPayerBilling CodesProprietary Laboratory AnalysesCPT cpt-0289u-mindx-blood-test-memory-alzheimers-ngs-rna-expression
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    CPT 0289U: MindX Blood Test – Memory/Alzheimer’s, NGS RNA Gene Expression

    CPT code 0289U is a Proprietary Laboratory Analysis (PLA) specific to the MindX Blood Test™ – Memory/Alzheimer’s from MindX Sciences™ Inc.; the test uses next-generation sequencing (NGS) of RNA on a blood specimen to evaluate expression of 24 genes and applies an algorithmic analysis to generate a predictive risk score for Alzheimer’s disease and other memory conditions, reported as a laboratory molecular diagnostic service typically performed in a clinical reference laboratory or specialty diagnostic laboratory setting.

    For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, B-Hemolytic Streptococcus Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an older adult or middle-aged individual presenting to a memory clinic or primary care practice with subjective memory complaints, mild cognitive impairment (MCI), or concern for early Alzheimer disease. The clinician documents symptoms such as progressive forgetfulness, difficulty with instrumental activities of daily living, or objective cognitive decline on screening tools (for example, MoCA or MMSE). After history, physical exam, cognitive testing, and review of medication/metabolic contributors, the clinician orders the MindX Blood Test™ – Memory/Alzheimer’s (0289U) to provide an adjunctive molecular risk assessment. A phlebotomy draw is performed in an outpatient laboratory or clinic setting; whole blood is sent to the proprietary laboratory (MindX Sciences™ Laboratory) for RNA extraction, next-generation sequencing (NGS) of a 24-gene expression panel, and algorithmic analysis. The laboratory returns a predictive risk score for Alzheimer’s or other memory conditions to the ordering provider. Results are incorporated into the clinical evaluation, discussed with the patient during follow-up, and used alongside neuroimaging, neuropsychological testing, and other biomarker data when available.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    0289UMindX Blood Test™ – Memory/Alzheimer’s (proprietary 24-gene RNA NGS expression assay with algorithmic risk score)Primary PLA test being ordered; laboratory sequencing and algorithmic analysis provide an adjunctive predictive risk score.
    36415Collection of venous blood by venipunctureCommonly performed immediately prior to sending specimen for the 0289U assay; billed for phlebotomy when separate from lab fees.
    81025Urine pregnancy test, non-automated, performed in the office (qualitative)Data not available in the input.
    96372Therapeutic, prophylactic, or diagnostic injection (specify)Data not available in the input.
    87635Infectious agent detection by nucleic acid (e.g., viral RNA)Data not available in the input.

    Note: Where the input contained no related CPT list beyond 0289U, standard ancillary codes such as specimen collection (36415) are included as commonly associated services in the clinical workflow.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    2279H0200XHome Health Registered Respiratory TherapistHome care fosters individual responsibility for self-management of chronic respiratory conditions. It includes individualized assessment based plans …
    207ZD0900XDermatopathology (Pathology) PhysicianA dermatopathologist is an expert in diagnosing and monitoring diseases of the skin including infectious, immunologic, degenerative, and neoplastic di…
    207RS0012XSleep Medicine (Internal Medicine) PhysicianAn Internist who practices Sleep Medicine is certified in the subspecialty of sleep medicine and specializes in the clinical assessment, physiologic t…
    171W00000XContractorFor the purposes of the Health Care Provider Taxonomy, a contractor is limited to individuals who do construction or mechanical work to modify a patie…

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    F01.50Vascular dementia, unspecified severity, without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety
    F02.80Dementia in other diseases classified elsewhere, unspecified severity, without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety
    F03.90Unspecified dementia, unspecified severity, without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety
    G30.0Alzheimer's disease with early onset
    G30.1Alzheimer's disease with late onset
    G30.8Other Alzheimer's disease
    G30.9Alzheimer's disease, unspecified
    G31.83Neurocognitive disorder with Lewy bodies
    G31.84Mild cognitive impairment of uncertain or unknown etiology
    G31.89Other specified degenerative diseases of nervous system

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    2 rows

    PolicyPayerEffective Date
    RTM Testing of Homocysteine Metabolism-Related ConditionsOscar Health2026-10-01
    Multimarker Serum Testing Related to Ovarian CancerBlue Cross Blue Shield - Rhode Island2026-09-01

    Related Codes

    CPT-0001U-PRECISETYPE-HEA-MULTIPLEX-RBC-ANTIGEN-GENOTYPING

    CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

    CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

    CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

    CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

    CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

    CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

    CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

    CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

    CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

    CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

    CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

    CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

    CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

    CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

    CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

    CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

    CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

    CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

    CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

    Showing 1–10 of 536

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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