Summary & Overview
CPT 0282U: Versiti Red Cell Genotyping Panel, 12-Gene/44-Antigen Analysis
CPT code 0282U is a Proprietary Laboratory Analyses (PLA) code that identifies the Versiti™ Red Cell Genotyping Panel, a lab-developed test that analyzes 12 blood group system genes to characterize expression of 44 red blood cell antigens. The panel supports clinical decision-making for transfusion management by helping identify antigen compatibility and reducing the risk of transfusion reactions. As a PLA CPT code, 0282U applies uniquely to a single manufacturer's test and is relevant to hospitals, blood banks, reference laboratories, and transfusion services nationwide.
Key payers in scope include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. The publication summarizes coverage and billing considerations across those payers, where available, and frames clinical context for use in pre-transfusion testing, complex transfusion planning, and immunohematology consultation.
Readers will learn what CPT code 0282U represents, the clinical applications of red cell genotyping, typical sites where the service is performed, and what information is available versus missing in the input data. The report also outlines common modifier usage provided in the input and highlights areas where payers and policy documents most often address PLA codes. Data not available in the input is noted explicitly where applicable.
Billing Code Overview
CPT code 0282U is a Proprietary Laboratory Analyses (PLA) code for the Versiti™ Red Cell Genotyping Panel from Versiti™ Diagnostic Laboratories. The test uses a specimen such as blood for genotype analysis of 12 blood group system genes involving the expression of 44 red blood cell antigens to help clinicians minimize adverse blood–type incompatibility reactions in blood transfusions.
Service type: Genetic/Genotyping Laboratory Test for Red Cell Antigen Profiling
Typical site of service: Specialty diagnostic laboratory or reference laboratory
Data not available in the input.
Clinical & Coding Specifications
Clinical Context
A typical patient scenario involves a hospitalized or outpatient adult or pediatric patient who requires extended red blood cell (RBC) antigen characterization to guide transfusion decisions. Common scenarios include patients with multiple prior transfusions, alloimmunization, hemoglobinopathies (such as sickle cell disease or thalassemia), planned chronic transfusion therapy, or patients with discrepant serologic typing. The clinical workflow: a clinician (hematologist, transfusion medicine specialist, or treating physician) orders the Versiti™ Red Cell Genotyping Panel. A blood specimen is collected and sent to the performing laboratory (Versiti™ Diagnostic Laboratories). The lab performs molecular genotyping of 12 blood group system genes covering expression of 44 RBC antigens. Results are reported to the ordering clinician and transfusion service to assist selection of antigen-matched donor units and to minimize hemolytic transfusion reactions and alloimmunization risk. Typical site of service is an outpatient phlebotomy collection center, hospital inpatient laboratory service, or a reference diagnostic laboratory. Providers involved include hematology, transfusion medicine, and blood bank services.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
00 | Unspecified; not commonly used in claims transmission | Rarely used; typically not applied to PLA codes unless required by payer |
22 | Increased procedural services | Use when work or complexity of specimen handling or reporting significantly exceeds typical for the test |
26 | Professional component | Use when reporting only the professional component (interpretation) separate from the laboratory technical component |
52 | Reduced services | Use when the lab performed a reduced portion of the panel (rare for PLA tests) |
53 | Discontinued procedure | Use if testing was started but discontinued for documented clinical reasons |
62 | Two surgeons/physicians | Not typically applicable; may be used if two physicians share interpretation responsibilities and payer requires modifier |
78 | Return to OR following complication | Not applicable to laboratory testing but retained for payer systems that accept it |
80 | Assistant surgeon | Not applicable to lab testing; sometimes submitted in error—avoid for PLA testing |
82 | Assistant (when qualified resident not available) | Not applicable to lab testing |
TC | Technical component | Use when reporting only the laboratory technical component separate from the professional interpretation |
| Taxonomy Code | Specialty | Notes |
|---|---|---|
| 207RH0000X | Hematology | Physicians who frequently order and interpret RBC genotyping for transfusion management |
| 207RR0500X | Blood Banking/Transfusion Medicine | Specialists who direct testing strategy and apply results for donor selection |
| 208000000X | Pathology | Anatomic and clinical pathologists who oversee laboratory testing and quality |
| 207LP2900X | Laboratory Director | Clinical laboratory directors responsible for reference testing oversight |
Related Diagnoses
| ICD-10 Code | Description | Clinical Relevance |
|---|---|---|
D57.0 | Hb-SS disease with crisis | Sickle cell disease patients frequently require extended antigen matching due to chronic transfusion and alloimmunization risk |
D57.1 | Sickle-cell disease without crisis | Chronic management may include genotyping to guide transfusions |
D56.1 | Beta thalassemia | Patients on chronic transfusion programs need antigen-matched units to prevent alloimmunization |
D63.1 | Anemia in chronic kidney disease | Transfusions may be required; genotyping can aid in selecting compatible units for sensitized patients |
Z51.3 | Encounter for blood transfusion | Procedure-related coding context where genotyping informs donor selection |
Z51.89 | Encounter for other specified aftercare | Post-transfusion management and evaluation when alloantibodies or reactions are assessed |
R71.8 | Other abnormality of red blood cells | Abnormal serologic typing or hemolytic tendencies prompting genotyping |
Related CPT Codes
| CPT Code | Description | Relationship to This Procedure |
|---|---|---|
0282U | Versiti™ Red Cell Genotyping Panel — genotype analysis of 12 blood group system genes (44 antigens) | Primary PLA code describing the proprietary panel performed by Versiti™ Diagnostic Laboratories |
86355 | Blood typing; RBC antibody screen, indirect antiglobulin (eg, IAT) | Performed prior to or alongside genotyping to detect alloantibodies and guide further testing |
86840 | Crossmatch, serologic (major) | Used to confirm compatibility of donor red cells with recipient serum; genotyping informs selection of antigen-negative units |
88120 | Cytogenetic analysis, blood — specimen processing and mapping (example of molecular cytogenetic technical processing) | Laboratory molecular testing workflows may use molecular lab infrastructure; not specific but related to molecular testing context |
87491 | Infectious agent detection by nucleic acid (qualitative), serious pathogens (example molecular test) | Represents the type of molecular lab testing methodology; included as commonly co-processed molecular assays in reference labs |