Summary & Overview
CPT 0269U: Versiti Autosomal Dominant Thrombocytopenia NGS Panel
CPT code 0269U designates a Proprietary Laboratory Analyses (PLA) test: the Versiti™ Autosomal Dominant Thrombocytopenia Panel, an NGS-based 22-gene panel for autosomal dominant congenital thrombocytopenia. As a PLA code, 0269U applies to a single manufacturer-specific assay and signals a targeted, proprietary genetic diagnostic service important for accurate diagnosis and familial risk assessment of inherited platelet disorders. Nationally, PLA codes like 0269U are significant because they identify unique laboratory offerings that can influence clinical decision-making, referral patterns, and coverage reviews.
Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the clinical context for the panel, how the code is used in claims, and what types of services and sites typically submit the code. The publication presents benchmarking and coverage considerations relevant to proprietary genetic tests, describes common billing practices for NGS panels, and highlights policy updates and payer pathways that commonly affect PLA-coded assays. This material is intended for billing managers, laboratory directors, clinical geneticists, and policy analysts seeking a national summary of CPT code 0269U and its operational and policy implications.
Billing Code Overview
CPT code 0269U is a Proprietary Laboratory Analyses (PLA) code for the Versiti™ Autosomal Dominant Thrombocytopenia Panel performed by Versiti™ Diagnostic Laboratories. The test uses next–generation sequencing (NGS) of 22 genes associated with autosomal dominant congenital thrombocytopenia and is reported for a single, specific laboratory assay. The panel may aid clinicians in diagnosing symptomatic patients with suspected inherited thrombocytopenia or in evaluating familial risk for autosomal dominant platelet disorders.
Service type: Genetic diagnostic testing (next–generation sequencing panel)
Typical site of service: Clinical laboratory or specialty diagnostic laboratory
Clinical & Coding Specifications
Clinical Context
A patient presents to a hematology clinic with lifelong, mild-to-moderate thrombocytopenia and a family history of low platelet counts and easy bruising. The hematologist orders the Versiti™ Autosomal Dominant Thrombocytopenia Panel (0269U) to evaluate for pathogenic variants in 22 genes associated with autosomal dominant congenital thrombocytopenia. Specimens accepted include peripheral blood, buccal swab, or amniotic fluid when prenatal family risk assessment is indicated. The clinical workflow: the ordering clinician documents indication and obtains informed consent for genetic testing, collects the appropriate specimen at an outpatient phlebotomy or genetic counseling visit (typical site of service: hospital outpatient lab, independent diagnostic laboratory, or specialty genetic testing center), labels and ships the specimen to Versiti™ Diagnostic Laboratories, and tracks results through the laboratory electronic result system. Results guide diagnosis, family counseling, and cascade testing for at-risk relatives; testing may also be used in prenatal risk evaluation when performed on amniotic fluid with appropriate maternal-fetal medicine involvement.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
00 | No modifier / default | Use when no specific modifier applies to the service billed. |