CPT code 0263U is a Proprietary Laboratory Analyses (PLA) code for the NPDX ASD and Central Carbon Energy Metabolism test from Stemina Biomarker Discovery Inc.; it represents a plasma-based laboratory analysis of 16 central carbon metabolites with an algorithmic interpretation to identify metabolic patterns consistent with an autism spectrum disorder (ASD) diagnosis, classified as a specialized clinical laboratory diagnostic test and typically performed in a clinical laboratory or reference lab setting using a plasma specimen.

For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, Genomic Profiling for Selecting Targeted Cancer Therapies.