CPT 0212U: Genomic Unity® Whole Genome Analysis — Proband

CPT code 0212U is a Proprietary Laboratory Analyses (PLA) code for the Genomic Unity® Whole Genome Analysis – Proband by Variantyx Inc., representing comprehensive whole genome and mitochondrial DNA sequencing and analysis performed to evaluate rare or unexplained constitutional or genetic disorders in the proband; service type is clinical laboratory genetic testing / whole genome analysis, and the typical site of service is a certified clinical molecular genetics laboratory or specialty reference lab.

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CPT 0212U: Genomic Unity® Whole Genome Analysis — Proband

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Clinical & Coding Specifications

Clinical Context

A pediatric or adult patient presents with an unexplained, likely genetic condition (for example, developmental delay, multiple congenital anomalies, progressive neurologic decline, cardiomyopathy of unclear etiology, or suspected mitochondrial disorder). Prior targeted testing (chromosomal microarray, single-gene testing, or targeted gene panels) is non-diagnostic or inconclusive. The ordering clinician (medical geneticist, genetic counselor, pediatric neurologist, or other specialist) documents a proband-focused evaluation and requests a comprehensive analysis of the whole genome including mitochondrial DNA. A blood or saliva specimen is collected per the laboratory’s instructions and sent to Variantyx Inc. for the Genomic Unity® Whole Genome Analysis – Proband (0212U). The laboratory performs whole genome sequencing and mitochondrial DNA analysis, bioinformatic variant calling and interpretation, and issues a clinical report summarizing pathogenic or likely pathogenic variants, variants of uncertain significance relevant to the phenotype, and recommended follow-up. Results are returned to the ordering clinician, who integrates findings with clinical data to guide diagnosis, cascade testing of family members if indicated, management, and possible referral for specialty care or clinical trial consideration. Typical sites of service include outpatient clinics, specialty genetics centers, and hospital outpatient draw stations; specimen collection may also occur in an inpatient setting for hospitalized patients with urgent diagnostic needs.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`81416`	Exome sequencing (eg, clinical exome); sequence analysis and interpretation	Alternative advanced genomic test; may be ordered prior to or instead of whole genome analysis depending on clinical strategy.
`81445`	Targeted genomic sequence analysis panel (e.g., disease-specific panel)	Often performed earlier in diagnostic workflow when phenotype suggests a focused panel before reflexing to whole genome analysis.
`0022U`*	Proprietary laboratory analyses — example PLA code	(If present) Other proprietary genomic tests may be performed alongside or as alternatives; specific PLA codes vary by manufacturer.
`99000`	Handling and processing of specimens (example)	Ancillary billing codes for specimen handling or courier services that may accompany testing logistics.
`88360`	Morphometric analysis (example histology adjunct)	Occasionally used for correlated tissue studies when genomic findings prompt pathologic review.

Related Modifiers

6 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RG0300X	Geriatric Medicine (Internal Medicine) Physician	An internist who has special knowledge of the aging process and special skills in the diagnostic, therapeutic, preventive and rehabilitative aspects o…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
207RP1002X	Physician Nutrition Specialist (Internal Medicine)	A physician who specializes in the diagnosis and treatment of primary nutritional diseases (e.g., undernutrition, overnutrition, and genetic or acquir…
207ZP0102X	Anatomic Pathology & Clinical Pathology Physician	A pathologist deals with the causes and nature of disease and contributes to diagnosis, prognosis and treatment through knowledge gained by the labora…
163WX0002X	High-Risk Obstetric Registered Nurse	Nursing Service Providers · Registered Nurse
163WR0006X	Registered Nurse First Assistant	A perioperative registered nurse who works in collaboration with the surgeon and other health care team members to achieve optimal outcomes. The RNFA…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
251C00000X	Developmentally Disabled Services Day Training Agency	These agencies are authorized to provide day habilitation services to developmentally disabled individuals who live in their homes. The function of d…

Related ICD-10-CM Codes

24 rows

ICD-10-CM Code	Description
C71.9	Malignant neoplasm of brain, unspecified
D80.9	Immunodeficiency with predominantly antibody defects, unspecified
D82.1	Di George's syndrome
E10.9	Type 1 diabetes mellitus without complications
E11.9	Type 2 diabetes mellitus without complications
E78.5	Hyperlipidemia, unspecified
F82	Specific developmental disorder of motor function
F84.0	Autistic disorder
G40.909	Epilepsy, unspecified, not intractable, without status epilepticus
G71.3	Mitochondrial myopathy, not elsewhere classified

Showing 1–10 of 24

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`81416`	Exome sequencing (eg, clinical exome); sequence analysis and interpretation	Alternative advanced genomic test; may be ordered prior to or instead of whole genome analysis depending on clinical strategy.
`81445`	Targeted genomic sequence analysis panel (e.g., disease-specific panel)	Often performed earlier in diagnostic workflow when phenotype suggests a focused panel before reflexing to whole genome analysis.
`0022U`*	Proprietary laboratory analyses — example PLA code	(If present) Other proprietary genomic tests may be performed alongside or as alternatives; specific PLA codes vary by manufacturer.
`99000`	Handling and processing of specimens (example)	Ancillary billing codes for specimen handling or courier services that may accompany testing logistics.
`88360`	Morphometric analysis (example histology adjunct)	Occasionally used for correlated tissue studies when genomic findings prompt pathologic review.

Related Modifiers

6 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RG0300X	Geriatric Medicine (Internal Medicine) Physician	An internist who has special knowledge of the aging process and special skills in the diagnostic, therapeutic, preventive and rehabilitative aspects o…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
207RP1002X	Physician Nutrition Specialist (Internal Medicine)	A physician who specializes in the diagnosis and treatment of primary nutritional diseases (e.g., undernutrition, overnutrition, and genetic or acquir…
207ZP0102X	Anatomic Pathology & Clinical Pathology Physician	A pathologist deals with the causes and nature of disease and contributes to diagnosis, prognosis and treatment through knowledge gained by the labora…
163WX0002X	High-Risk Obstetric Registered Nurse	Nursing Service Providers · Registered Nurse
163WR0006X	Registered Nurse First Assistant	A perioperative registered nurse who works in collaboration with the surgeon and other health care team members to achieve optimal outcomes. The RNFA…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
251C00000X	Developmentally Disabled Services Day Training Agency	These agencies are authorized to provide day habilitation services to developmentally disabled individuals who live in their homes. The function of d…

Related ICD-10-CM Codes

24 rows

ICD-10-CM Code	Description
C71.9	Malignant neoplasm of brain, unspecified
D80.9	Immunodeficiency with predominantly antibody defects, unspecified
D82.1	Di George's syndrome
E10.9	Type 1 diabetes mellitus without complications
E11.9	Type 2 diabetes mellitus without complications
E78.5	Hyperlipidemia, unspecified
F82	Specific developmental disorder of motor function
F84.0	Autistic disorder
G40.909	Epilepsy, unspecified, not intractable, without status epilepticus
G71.3	Mitochondrial myopathy, not elsewhere classified

Showing 1–10 of 24

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 0212U: Genomic Unity® Whole Genome Analysis — Proband

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OpenPayer

CPT 0212U: Genomic Unity® Whole Genome Analysis — Proband

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

CPT 0212U: Genomic Unity® Whole Genome Analysis — Proband

Sign up for cpt 0212U policy alerts

CPT 0212U: Genomic Unity® Whole Genome Analysis — Proband

Sign up for cpt 0212U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does CPT 0212U represent and when is it used?

Who orders 0212U and where is the test usually performed?

Which billing modifiers are relevant for 0212U?

What related CPT codes might appear alongside or instead of 0212U?

Is 0212U covered by major payers and does the page provide reimbursement amounts or coverage rules?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does CPT 0212U represent and when is it used?

Who orders 0212U and where is the test usually performed?

Which billing modifiers are relevant for 0212U?

What related CPT codes might appear alongside or instead of 0212U?

Is 0212U covered by major payers and does the page provide reimbursement amounts or coverage rules?

References