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    v1.0.30
    OpenPayerBilling CodesProprietary Laboratory AnalysesCPT cpt-0205u-vita-risk-macular-degeneration-zinc-risk
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    CPT 0205U: Vita Risk® Test for AMD Progression with Zinc

    CPT code 0205U is a Proprietary Laboratory Analyses (PLA) code describing the Vita Risk® test by Arctic Medical Laboratories, a molecular diagnostic assay that evaluates whether a patient has an increased risk of progressing from dry to wet age-related macular degeneration (AMD) when taking zinc supplements; service type: laboratory diagnostic test, typical site of service: outpatient clinical laboratory or specialty ophthalmology clinic specimen collection site.

    For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency, Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policy.

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    Clinical & Coding Specifications

    Clinical Context

    A 72-year-old patient with intermediate dry age-related macular degeneration (AMD) presents to a retinal specialist for risk stratification prior to initiating or continuing oral zinc-containing supplementation. The clinician orders the Vita Risk® test (0205U) from Arctic Medical Laboratories to evaluate the patient’s genetic and biomarker profile associated with progression from dry (non-neovascular) to wet (neovascular) AMD when zinc supplements are used. Typical workflow: the retina clinic or ophthalmology practice collects a blood sample or buccal swab per the lab’s kit instructions during an outpatient visit; the specimen is shipped to the performing laboratory. Results return to the ordering clinician electronically and are reviewed in follow-up to inform counseling about supplement safety and monitoring frequency. Typical site of service: outpatient ophthalmology or retinal specialty clinic, ambulatory laboratory collection center, or home specimen collection arranged by the laboratory.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    0205UVita Risk® test (Proprietary Laboratory Analyses) — identifies increased risk of progression from dry to wet AMD with zinc supplementationPrimary PLA code describing the specific proprietary assay performed by Arctic Medical Laboratories.
    36415Collection of venous blood by venipunctureCommonly performed immediately prior to sending a sample to the laboratory when blood is the required specimen for the Vita Risk® test.
    99000Handling and/or conveyance of specimen for transfer from the physician’s office to a laboratoryUsed when the clinic bills for specimen collection handling or courier services per payer rules.
    G0008Data not available in the input.Data not available in the input.
    86328Immunoassay for infectious agent antibody(ies)Data not available in the input.

    Note: Where specific related codes were not provided in the input, common specimen collection and handling CPT codes are listed to reflect routine clinical workflow around a proprietary laboratory assay.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208C00000X
    207K00000X
    363A00000X
    207L00000X
    163WN0003X
    207RG0300X
    347B00000X
    225X00000X

    Related ICD-10-CM Codes

    19 rows

    ICD-10-CM CodeDescription
    E11.319Type 2 diabetes mellitus with unspecified diabetic retinopathy without macular edema
    E11.65Type 2 diabetes mellitus with hyperglycemia
    E78.5Hyperlipidemia, unspecified
    H35.20Other non-diabetic proliferative retinopathy, unspecified eye
    H35.21Other non-diabetic proliferative retinopathy, right eye
    H35.30Unspecified macular degeneration
    H35.33Angioid streaks of macula
    H35.40Unspecified peripheral retinal degeneration
    H40.9Unspecified glaucoma
    H52.13Myopia, bilateral

    Showing 1–10 of 19

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Carrier Testing Panels for Genetic Diseases (for Kentucky Only)UnitedHealthcare2026-10-01
    Genetic Testing for Neurological Disorders (for Kansas Only)UnitedHealthcare2026-10-01
    Genetic and Molecular TestingProvidence Health Plan2026-10-01
    Cell-Free Fetal DNA Testing (for Idaho Only)UnitedHealthcare2026-10-01
    Next Generation Sequencing for Minimal Residual Disease DetectionProvidence Health Plan2026-10-01
    Pharmacogenetic Panel Testing (for Kansas Only)UnitedHealthcare2026-10-01
    Non-Covered Genetic Panel TestsProvidence Health Plan2026-10-01

    Related Codes

    CPT-0001U-PRECISETYPE-HEA-MULTIPLEX-RBC-ANTIGEN-GENOTYPING

    CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

    CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

    CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

    CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

    CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

    CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

    CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

    CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

    CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

    CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

    CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

    CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

    CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

    CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

    CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

    CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

    CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

    CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

    CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

    Showing 1–10 of 536

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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