CPT code 0198U is a Proprietary Laboratory Analyses (PLA) code for the Navigator RHD/CE Sequencing test (Grifols Immunohematology Center) that sequences specific Rh blood group gene regions from a blood specimen to determine Rh antigens; this molecular diagnostic service is a targeted genetic sequencing test typically billed as a laboratory molecular pathology/genetics service and performed in a clinical laboratory or reference lab setting for use in transfusion medicine, organ transplant compatibility assessment, and prenatal/newborn blood–type incompatibility risk evaluation.

For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, Genomic Profiling for Selecting Targeted Cancer Therapies.