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    v1.0.28
    OpenPayerBilling CodesProprietary Laboratory AnalysesCPT cpt-0197u-navigator-lw-sequencing-lw-blood-group-antigen-analysis
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    CPT 0197U: Navigator LW Sequencing for LW Blood Group Antigens

    CPT code 0197U is a Proprietary Laboratory Analyses (PLA) test for the Navigator LW Sequencing assay from Grifols Immunohematology Center that sequences specific gene regions to determine Landsteiner–Wiener (LW) blood group antigens; this molecular blood group genotyping service is performed on a blood specimen and is used to help clinicians minimize adverse blood-type incompatibility reactions in transfusion, transplant, pregnancy, and newborn care. Service type: Molecular diagnostic blood group genotyping. Typical site of service: Clinical laboratory or reference immunohematology laboratory using blood specimens.

    For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, B-Hemolytic Streptococcus Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A 32-year-old pregnant woman with a history of a prior hemolytic transfusion reaction presents at an obstetrics clinic for prenatal care. Her blood bank records show discrepant or weak reactivity on standard serologic testing suggestive of uncommon Landsteiner–Wiener (LW) blood group antigen expression. The obstetrician orders a molecular blood group test — the Navigator LW Sequencing test (Grifols Immunohematology Center) — to sequence the specific LW-related gene regions from a peripheral blood specimen. The laboratory receives the EDTA whole blood sample, performs DNA extraction and targeted sequencing per the proprietary assay, and reports LW antigen genotype results to the transfusion medicine service and the obstetric team. Results inform selection of compatible donor blood for transfusion during delivery and guide fetal/newborn risk assessment for hemolytic disease of the fetus/newborn (HDFN). Typical workflow steps: specimen collection (blood), test requisition with clinical indication (e.g., prior transfusion reaction, serologic discrepancy, pregnancy with alloimmunization), transport to the reference lab, sequencing and interpretation by the performing laboratory, and an electronic report transmitted to the ordering clinician and blood bank to support transfusion or perinatal management decisions.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    86900Blood typing; ABOPerformed before or alongside molecular testing to establish routine blood group antigens and guide initial transfusion compatibility.
    86901Blood typing; Rh(D)Standard serologic Rh(D) typing commonly performed in transfusion and prenatal evaluation prior to or concurrently with specialized LW genotyping.
    86850Antibody screenDetects unexpected alloantibodies; positive or discrepant serology often prompts referral for specialized molecular testing like Navigator LW Sequencing.
    88271Microdeletion or duplication detection by MLPA, probe or PCR based (example molecular procedures)Other molecular methodologies for blood group or genetic testing that may be performed in the lab workflow; conceptually related though different technique.
    88299Unlisted cytogenetic study procedureMay be used when billing uncommon or proprietary molecular procedures if a PLA code is not applicable; for PLA code 0197U the proprietary PLA CPT is reported instead.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RG0100XGastroenterology PhysicianAn internist who specializes in diagnosis and treatment of diseases of the digestive organs including the stomach, bowels, liver and gallbladder. This…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    103TW0100XDeactivated - Psychotherapy Women
    207RA0201XAllergy & Immunology (Internal Medicine) PhysicianAn internist doctor of osteopathy that specializes in the treatment of allergy and immunologic disorders. A doctor of osteopathy that is board eligib…
    284300000XSpecial HospitalA designation by the AHA of a hospital whose primary function of the institution is to provide diagnostic and treatment services for patients who have…
    317400000XDeactivated - Christian Science FacilityInactive, use 282J00000X
    2278P1005XPulmonary Rehabilitation Certified Respiratory TherapistThe respiratory therapist can assist the chronic pulmonary patient in returning to an optimal role in society by providing an effective program. It i…
    2085R0203XTherapeutic Radiology PhysicianTherapeutic Radiology certificate name was changed to Radiation Oncology. Use Radiation Oncology.

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    D50.9Iron deficiency anemia, unspecified
    D51.0Vitamin B12 deficiency anemia due to intrinsic factor deficiency
    D56.9Thalassemia, unspecified
    D68.9Coagulation defect, unspecified
    D69.6Thrombocytopenia, unspecified
    O14.03Mild to moderate pre-eclampsia, third trimester
    O36.8230Fetal anemia and thrombocytopenia, third trimester, not applicable or unspecified
    O36.8231Fetal anemia and thrombocytopenia, third trimester, fetus 1
    O36.8232Fetal anemia and thrombocytopenia, third trimester, fetus 2
    O36.8930Maternal care for other specified fetal problems, third trimester, not applicable or unspecified

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    2 rows

    PolicyPayerEffective Date
    RTM Testing of Homocysteine Metabolism-Related ConditionsOscar Health2026-10-01
    Multimarker Serum Testing Related to Ovarian CancerBlue Cross Blue Shield - Rhode Island2026-09-01

    Related Codes

    CPT-0001U-PRECISETYPE-HEA-MULTIPLEX-RBC-ANTIGEN-GENOTYPING

    CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

    CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

    CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

    CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

    CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

    CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

    CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

    CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

    CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

    CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

    CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

    CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

    CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

    CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

    CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

    CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

    CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

    CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

    CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

    Showing 1–10 of 536

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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