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    v1.0.28
    OpenPayerBilling CodesProprietary Laboratory AnalysesCPT cpt-0194u-kell-blood-group-sequencing-navigator-kel
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    CPT 0194U: Navigator KEL Sequencing for Kell Blood Group Antigens

    CPT code 0194U is a Proprietary Laboratory Analyses (PLA) code for the Navigator KEL Sequencing test from Grifols Immunohematology Center that sequences specific gene regions to identify Kell blood group antigens, supporting clinical decisions to minimize adverse blood–type incompatibility reactions in blood transfusion, organ transplant, pregnancy, and newborn management; this service is a molecular diagnostic genetic sequencing test typically performed on blood specimens in a clinical laboratory setting.

    For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, B-Hemolytic Streptococcus Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a pregnant person, a blood transfusion candidate, or an organ transplant recipient whose care team needs high-resolution Kell blood group genotyping to minimize immune-mediated hemolytic reactions. A prenatal scenario: a 28-year-old pregnant patient with a history of alloimmunization or a positive maternal antibody screen is referred for molecular Kell antigen genotyping to determine fetal risk and guide perinatal management. A transfusion scenario: a hospitalized adult requiring multiple red blood cell transfusions with discrepant serologic typing or a history of transfusion reactions undergoes testing to identify variant Kell alleles. A pre-transplant scenario: a kidney transplant candidate with complex serology is tested to refine donor compatibility.

    Clinical workflow: a clinician orders the Navigator KEL Sequencing test (0194U) at the hospital or outpatient clinic. A peripheral blood specimen is collected and sent to Grifols Immunohematology Center. The laboratory performs targeted sequencing of Kell gene regions, interprets alleles relevant to Kell blood group antigens, and issues a report indicating antigen predictions and any variant alleles. Results are used by transfusion medicine, obstetrics, or transplant teams to match blood products, monitor pregnancies for hemolytic disease of the fetus/newborn, or inform donor selection.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    81025Urinalysis, automated, with microscopyPre-test screening in hospitalized patients; not directly related but part of baseline labs prior to transfusion or transplant
    36415Collection of venous blood by venipunctureSpecimen collection for the Navigator KEL Sequencing test; commonly performed at the time of order
    88045Antibody identification; including adsorption/elution techniques (per sample)Serologic workup often performed before or alongside molecular Kell genotyping to resolve discrepant or complex antibody results
    86850Blood typing; ABO (including Rh antigen)Routine serologic blood typing performed as part of transfusion compatibility evaluation prior to molecular testing
    86880Antibody screen (indirect antiglobulin test)Initial screen for alloantibodies that may prompt Kell genotyping with 0194U
    0000UProprietary Laboratory Analyses example (placeholder)Example of other PLA codes that may be ordered alongside 0194U when comprehensive antigen genotyping panels are performed

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    2080P0206XPediatric Gastroenterology PhysicianA pediatrician who specializes in the diagnosis and treatment of diseases of the digestive systems of infants, children and adolescents. This speciali…
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    2084N0400XNeurology PhysicianA Neurologist specializes in the diagnosis and treatment of diseases or impaired function of the brain, spinal cord, peripheral nerves, muscles, auton…
    364SN0000XNeonatal Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    204C00000XSports Medicine (Neuromusculoskeletal Medicine) PhysicianA Neuromusculoskeletal Medicine and Osteopathic Manipulative Medicine physician trained to be responsible for the continuous care in the field of spor…
    183500000XPharmacistAn individual licensed by the appropriate state regulatory agency to engage in the practice of pharmacy. The practice of pharmacy includes, but is no…

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    2 rows

    PolicyPayerEffective Date
    RTM Testing of Homocysteine Metabolism-Related ConditionsOscar Health2026-10-01
    Multimarker Serum Testing Related to Ovarian CancerBlue Cross Blue Shield - Rhode Island2026-09-01

    Related Codes

    CPT-0001U-PRECISETYPE-HEA-MULTIPLEX-RBC-ANTIGEN-GENOTYPING

    CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

    CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

    CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

    CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

    CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

    CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

    CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

    CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

    CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

    CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

    CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

    CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

    CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

    CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

    CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

    CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

    CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

    CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

    CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

    Showing 1–10 of 536

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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