CPT 0180U: Navigator ABO Sequencing Test

CPT code 0180U is a Proprietary Laboratory Analyses (PLA) code for the Navigator ABO Sequencing test from Grifols Immunohematology Center that evaluates specific gene sequences to determine ABO blood group antigens; service type: targeted genetic sequencing/ABO genotyping; typical site of service: clinical laboratory using a blood specimen, supporting clinical decisions for blood transfusion, organ transplantation, and perinatal/newborn care.

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CPT 0180U: Navigator ABO Sequencing Test

Customize your policy alerts

Sign up for cpt 0180U policy alerts

Get alerted when payer policies referencing 0180U are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A patient scheduled for a complex transfusion evaluation or pre-transplant compatibility workup presents to a hospital transfusion medicine service or an immunohematology reference laboratory. A specimen of whole blood is collected and sent to the specialized laboratory for the Navigator ABO Sequencing test (0180U) to determine ABO gene sequence variants that influence blood group antigen expression. Typical indications include resolving discrepant or weak ABO serologic typing results, investigation of hemolytic disease of the fetus and newborn, pre-transfusion assessment for patients with a history of transfusion reactions, and pre-transplant donor–recipient compatibility evaluation. The clinical workflow begins with clinician order entry and specimen collection using standard blood bank tubes, couriered to the Grifols Immunohematology Center. The laboratory performs nucleic acid extraction, targeted sequencing of the ABO gene regions specified by the proprietary assay, bioinformatic analysis, and result reporting to the requesting transfusion medicine physician, hematologist, obstetrician, or transplant team. Results inform selection of compatible blood products, guide prenatal counseling when maternal–fetal ABO incompatibility is suspected, and assist transplant teams in minimizing ABO-related graft risks.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`86900`	Blood typing; ABO and Rh	Often performed prior to or alongside sequencing to establish serologic ABO and Rh status
`86901`	Blood typing; ABO only	May be used when only ABO serologic typing is initially performed before molecular testing
`86905`	Blood typing; Rh (D)	Performed in parallel to characterize Rh status for transfusion planning
`81265`	HFE (hereditary hemochromatosis) gene analysis	Example of another molecular blood-related test; not directly related but similar laboratory workflow
`81479`	Unlisted molecular pathology procedure	Sometimes used historically for proprietary molecular tests before adoption of PLA codes; sequencing `0180U` replaces use of unlisted codes

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
81	Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…	- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
47	Modifier -47 (“Anesthesia by Surgeon”) is appended to a surgical or procedural CPT code when the surgeon personally provides regional or general anesthesia for the procedure. Use of -47 indicates the…	- Use modifier -47 when the surgeon personally provides regional or general anesthesia during the surgical procedure (i.e., the surgeon administers the anesthesia in addition to performing the…
58	Modifier 58 (Staged or related procedure/service by the same physician during the postoperative period) indicates that a subsequent procedure performed by the same provider during the…	- Use modifier 58 when the same physician/QHP performs a procedure during the postoperative/global period of an earlier procedure and the subsequent procedure is either planned or anticipated…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207R00000X	Internal Medicine Physician	A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
2081P2900X	Pain Medicine (Physical Medicine & Rehabilitation) Physician	A physician who provides a high level of care, either as a primary physician or consultant, for patients experiencing problems with acute, chronic or …
364SS0200X	School Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
172A00000X	Driver	A person employed to operate a motor vehicle as a carrier of persons or property.
2471Q0001X	Quality Management Radiologic Technologist	A radiologic technologist who specializes in quality management.
246W00000X	Cardiology Technician	An individual who has knowledge of specific techniques, instruments, and equipment required in performing specific cardiovascular/peripheral vascular …

Related ICD-10-CM Codes

26 rows

ICD-10-CM Code	Description
D56.1	Beta thalassemia
D68.9	Coagulation defect, unspecified
O36.0130	Maternal care for anti-D [Rh] antibodies, third trimester, not applicable or unspecified
O36.0131	Maternal care for anti-D [Rh] antibodies, third trimester, fetus 1
O36.0132	Maternal care for anti-D [Rh] antibodies, third trimester, fetus 2
O36.0139	Maternal care for anti-D [Rh] antibodies, third trimester, other fetus
O36.4XX0	Maternal care for intrauterine death, not applicable or unspecified
O36.4XX1	Maternal care for intrauterine death, fetus 1
O36.4XX2	Maternal care for intrauterine death, fetus 2
O36.4XX9	Maternal care for intrauterine death, other fetus

Showing 1–10 of 26

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`86900`	Blood typing; ABO and Rh	Often performed prior to or alongside sequencing to establish serologic ABO and Rh status
`86901`	Blood typing; ABO only	May be used when only ABO serologic typing is initially performed before molecular testing
`86905`	Blood typing; Rh (D)	Performed in parallel to characterize Rh status for transfusion planning
`81265`	HFE (hereditary hemochromatosis) gene analysis	Example of another molecular blood-related test; not directly related but similar laboratory workflow
`81479`	Unlisted molecular pathology procedure	Sometimes used historically for proprietary molecular tests before adoption of PLA codes; sequencing `0180U` replaces use of unlisted codes

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
81	Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…	- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
47	Modifier -47 (“Anesthesia by Surgeon”) is appended to a surgical or procedural CPT code when the surgeon personally provides regional or general anesthesia for the procedure. Use of -47 indicates the…	- Use modifier -47 when the surgeon personally provides regional or general anesthesia during the surgical procedure (i.e., the surgeon administers the anesthesia in addition to performing the…
58	Modifier 58 (Staged or related procedure/service by the same physician during the postoperative period) indicates that a subsequent procedure performed by the same provider during the…	- Use modifier 58 when the same physician/QHP performs a procedure during the postoperative/global period of an earlier procedure and the subsequent procedure is either planned or anticipated…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207R00000X	Internal Medicine Physician	A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
2081P2900X	Pain Medicine (Physical Medicine & Rehabilitation) Physician	A physician who provides a high level of care, either as a primary physician or consultant, for patients experiencing problems with acute, chronic or …
364SS0200X	School Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
172A00000X	Driver	A person employed to operate a motor vehicle as a carrier of persons or property.
2471Q0001X	Quality Management Radiologic Technologist	A radiologic technologist who specializes in quality management.
246W00000X	Cardiology Technician	An individual who has knowledge of specific techniques, instruments, and equipment required in performing specific cardiovascular/peripheral vascular …

Related ICD-10-CM Codes

26 rows

ICD-10-CM Code	Description
D56.1	Beta thalassemia
D68.9	Coagulation defect, unspecified
O36.0130	Maternal care for anti-D [Rh] antibodies, third trimester, not applicable or unspecified
O36.0131	Maternal care for anti-D [Rh] antibodies, third trimester, fetus 1
O36.0132	Maternal care for anti-D [Rh] antibodies, third trimester, fetus 2
O36.0139	Maternal care for anti-D [Rh] antibodies, third trimester, other fetus
O36.4XX0	Maternal care for intrauterine death, not applicable or unspecified
O36.4XX1	Maternal care for intrauterine death, fetus 1
O36.4XX2	Maternal care for intrauterine death, fetus 2
O36.4XX9	Maternal care for intrauterine death, other fetus

Showing 1–10 of 26

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 0180U: Navigator ABO Sequencing Test

Sign up for cpt 0180U policy alerts

OpenPayer

CPT 0180U: Navigator ABO Sequencing Test

Sign up for cpt 0180U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

CPT 0180U: Navigator ABO Sequencing Test

Sign up for cpt 0180U policy alerts

CPT 0180U: Navigator ABO Sequencing Test

Sign up for cpt 0180U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does CPT 0180U represent and when is it used?

For which clinical situations is the Navigator ABO Sequencing test indicated?

What is the specimen and laboratory workflow for this test?

Are there related CPT codes that are commonly ordered with or instead of 0180U?

Which payers cover CPT 0180U and where can I find reimbursement details?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does CPT 0180U represent and when is it used?

For which clinical situations is the Navigator ABO Sequencing test indicated?

What is the specimen and laboratory workflow for this test?

Are there related CPT codes that are commonly ordered with or instead of 0180U?

Which payers cover CPT 0180U and where can I find reimbursement details?

References