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    v1.0.28
    OpenPayerBilling CodesProprietary Laboratory AnalysesCPT cpt-0176u-ibschek-ibd-related-antibody-immunoassay
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    CPT 0176U: IBSchek® CdtB and Vinculin IgG Immunoassay

    CPT code 0176U is a Proprietary Laboratory Analyses (PLA) code for the IBSchek® immunoassay from Commonwealth Diagnostics International that detects CdtB and vinculin IgG antibodies in blood as a laboratory test to support evaluation for irritable bowel syndrome; service type: targeted serologic immunoassay for IBS biomarkers; typical site of service: outpatient clinical laboratory or reference laboratory performing proprietary diagnostic testing.

    For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, B-Hemolytic Streptococcus Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A 34-year-old patient presents to a gastroenterology clinic with a 2-year history of recurrent abdominal pain, bloating, and alternating constipation and diarrhea. Prior workup including stool studies, basic labs, celiac serology, and colonoscopy with biopsies were unrevealing for inflammatory bowel disease, celiac disease, or infection. The gastroenterologist considers post-infectious irritable bowel syndrome (IBS) as a working diagnosis and orders the proprietary immunoassay test IBSchek® to evaluate for serum IgG antibodies to cytolethal distending toxin B (CdtB) and vinculin.

    The clinical workflow: the provider documents symptoms, prior negative evaluations, and orders test 0176U in the electronic medical record with appropriate specimen collection instructions. A peripheral blood specimen is drawn at the clinic or an outpatient lab collection site (typical site of service: outpatient clinic or independent laboratory). The specimen is sent to Commonwealth Diagnostics International for analysis. Results reporting includes qualitative/quantitative antibody levels and interpretive guidance indicating whether antibody patterns are consistent with IBS. The ordering provider reviews results, documents interpretation in the medical record, and integrates findings into the diagnostic formulation and management planning for the patient.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    81002Urinalysis, by dipstick or tablet reagent; non-automated, without microscopyOften ordered in initial GI or abdominal pain workup to exclude urinary causes prior to targeted IBS testing
    83036Hemoglobin; glycosylated (A1C)Ordered when evaluating systemic or metabolic contributors to symptoms, frequently part of general workup
    82784Ferroxidase (serum ferritin)Ferritin testing is commonly performed to assess for iron deficiency contributing to fatigue or GI blood loss before attributing symptoms to IBS
    80053Comprehensive metabolic panelRoutinely ordered as part of baseline evaluation of patients with chronic GI complaints prior to specialized testing like 0176U
    81025Urine pregnancy test, by visual color comparison methodsPerformed in women of childbearing potential as part of initial evaluation before imaging or other diagnostic steps

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207R00000XInternal Medicine PhysicianA physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    213E00000XPodiatristA podiatrist is a person qualified by a Doctor of Podiatric Medicine (D.P.M.) degree, licensed by the state, and practicing within the scope of that l…
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    204D00000XNeuromusculoskeletal Medicine & OMM PhysicianThe Neuromusculoskeletal Medicine and Osteopathic Manipulative Medicine physician directs special attention to the neuromusculoskeletal system and its…
    132700000XDietary ManagerA dietary manager is a trained food services professional who is charged with maintaining cost/profit objectives, purchasing foods and services for th…
    364S00000XClinical Nurse SpecialistA registered nurse who, through a graduate degree program in nursing, or through a formal post-basic education program or continuing education courses…

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    E86.0Dehydration
    F45.41Pain disorder exclusively related to psychological factors
    K52.9Noninfective gastroenteritis and colitis, unspecified
    K58.0Irritable bowel syndrome with diarrhea
    K58.1Irritable bowel syndrome with constipation
    K58.2Mixed irritable bowel syndrome
    K58.8Other irritable bowel syndrome
    K59.1Functional diarrhea
    K59.9Functional intestinal disorder, unspecified
    N39.0Urinary tract infection, site not specified

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    2 rows

    PolicyPayerEffective Date
    RTM Testing of Homocysteine Metabolism-Related ConditionsOscar Health2026-10-01
    Multimarker Serum Testing Related to Ovarian CancerBlue Cross Blue Shield - Rhode Island2026-09-01

    Related Codes

    CPT-0001U-PRECISETYPE-HEA-MULTIPLEX-RBC-ANTIGEN-GENOTYPING

    CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

    CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

    CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

    CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

    CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

    CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

    CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

    CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

    CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

    CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

    CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

    CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

    CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

    CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

    CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

    CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

    CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

    CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

    CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

    Showing 1–10 of 536

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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