CPT 0140U: ePlex BCID Fungal Pathogens Panel, Rapid Molecular Detection

CPT code 0140U designates a Proprietary Laboratory Analyses (PLA) test for the ePlex® BCID Fungal Pathogens Panel by GenMark Diagnostics Inc., a molecular diagnostic assay that rapidly detects 15 fungal targets from positive blood cultures. As a PLA code, 0140U is specific to a single manufacturer's test and matters nationally because rapid fungal identification from bloodstream infections can influence antimicrobial management, infection control, and laboratory workflows.

Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find information on payer coverage patterns and contract considerations for PLA tests, typical clinical contexts for ordering the panel, and benchmarking topics relevant to hospital and clinical microbiology laboratories. The publication also provides operational context such as common sites of service and the molecular diagnostic service type, plus a concise list of common billing modifiers provided in the input.

The reader will learn where this test fits clinically, how PLA designation affects coding and payer conversations, and what operational stakeholders should consider when implementing or reporting the assay. Data not available in the input is noted where applicable.

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Billing Code Overview

CPT code 0140U is a Proprietary Laboratory Analyses (PLA) code for the ePlex® BCID Fungal Pathogens Panel from GenMark Diagnostics Inc. The test uses an automated amplified probe technique for rapid detection of 15 common and emerging fungal targets from positive blood cultures. This code applies only to the single, specific laboratory test provided by the manufacturer/laboratory.

Service type: Molecular diagnostic infectious disease testing using an automated amplified probe platform
Typical site of service: Hospital laboratory or clinical microbiology laboratory processing positive blood culture specimens

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CPT 0140U: ePlex BCID Fungal Pathogens Panel, Rapid Molecular Detection

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Get alerted when payer policies referencing 0140U are released or updated.

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Billing Code Overview

Service type: Molecular diagnostic infectious disease testing using an automated amplified probe platform
Typical site of service: Hospital laboratory or clinical microbiology laboratory processing positive blood culture specimens

Clinical & Coding Specifications

Clinical Context

A hospitalized adult patient presents with sepsis or clinical evidence of bloodstream infection (fever, hypotension, leukocytosis) and blood cultures are obtained. One or more aerobic or anaerobic blood culture bottles flag positive in the microbiology lab. The clinical team sends the positive blood culture broth to the hospital molecular laboratory or a contracted reference lab for rapid organism identification and resistance marker detection using the ePlex® BCID Fungal Pathogens Panel (GenMark Diagnostics Inc.). The test uses an automated amplified probe technique to detect 15 fungal targets directly from positive blood culture material, providing results faster than culture-based identification. Typical workflow: collection of blood cultures in the emergency department or inpatient unit → incubation in the microbiology instrument → positive signal from culture bottles → Gram stain and preliminary microscopy → order and accessioning of the 0140U fungal panel → sample preparation and run on the ePlex instrument → result verification and release to the electronic medical record → antimicrobial or antifungal therapy decisions informed by panel results. Typical sites of service include hospital inpatient laboratories, hospital-based microbiology labs, and contracted reference laboratories performing specialty molecular testing.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`A41.9`	Sepsis, unspecified organism	Common clinical scenario prompting blood cultures and rapid fungal pathogen testing.

B37.7 | Candidal sepsis | Directly relevant for fungal bloodstream infection detection by the ePlex BCID Fungal Pathogens Panel.

B44.9 | Aspergillosis, unspecified | Relevant when invasive aspergillosis is suspected and rapid detection from blood culture is pursued.

R65.20 | Severe sepsis without septic shock | Clinical context where rapid pathogen identification guides therapy.

B96.4 | Candidiasis as the cause of disease classified elsewhere | Used when a fungal species identified by the panel is recorded as causal organism for a systemic infection.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`87070`	Culture, other source, bacterial; with isolation and presumptive identification of isolates	Performed when blood culture yields organisms requiring growth-based confirmation in addition to molecular identification.

87491 | Infectious agent detection by nucleic acid (DNA or RNA); direct probe technique, pathogen-specific (e.g., single target) | Related nucleic acid detection methods; used for targeted molecular detection when different platforms or single-target assays are ordered.

87899 | Unlisted infectious disease microbiology procedure | Used when a specific proprietary assay lacks an exact CPT entry in some billing systems (though 0140U is the PLA code for this test).

87077 | Culture, blood, bacterial isolation and presumptive identification | Blood culture processing codes performed in the microbiology lab prior to or alongside molecular panels.

0000U is not provided in input and must not be added | Data not applicable | Data not applicable

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Professional component	Use when a separate entity reports professional interpretation or reporting (rare for automated PLA tests) alongside technical reporting.
52	Reduced services	Use when test was performed but results limited due to specimen quality, partial run, or instrument failure leading to a reduced-scope report.
53	Discontinued procedure	Use when testing was started but discontinued for clinical or technical reasons prior to completion.
78	Return to the operating room (not typically applicable)	Generally not applicable for this laboratory test; retained in modifier list but used rarely in lab context.
82	Assistant surgeon (unrelated)	Not applicable to laboratory testing but included in the original modifier list.

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RG0100X	Infectious Disease Physician	Clinicians who interpret results to direct antifungal therapy and stewardship.
207L00000X	Clinical Pathology	Pathologists who oversee laboratory testing and result validation.
163W00000X	Critical Care Medicine	Critical care providers who order rapid fungal diagnostics for septic patients.
207P00000X	Emergency Medicine Physician	An emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
282NC2000X	Children's Hospital	Hospitals · General Acute Care Hospital
1835E0208X	Emergency Medicine Pharmacist	A licensed pharmacist who has demonstrated specialized knowledge and skill in the care for patients at the bedside in emergency medicine settings.
246ZS0410X	Surgical Technologist	Surgical technologists are allied health professionals, who are an integral part of the team of medical practitioners providing surgical care to patie…
207RP1002X	Physician Nutrition Specialist (Internal Medicine)	A physician who specializes in the diagnosis and treatment of primary nutritional diseases (e.g., undernutrition, overnutrition, and genetic or acquir…

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CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

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Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`A41.9`	Sepsis, unspecified organism	Common clinical scenario prompting blood cultures and rapid fungal pathogen testing.

B37.7 | Candidal sepsis | Directly relevant for fungal bloodstream infection detection by the ePlex BCID Fungal Pathogens Panel.

B44.9 | Aspergillosis, unspecified | Relevant when invasive aspergillosis is suspected and rapid detection from blood culture is pursued.

R65.20 | Severe sepsis without septic shock | Clinical context where rapid pathogen identification guides therapy.

B96.4 | Candidiasis as the cause of disease classified elsewhere | Used when a fungal species identified by the panel is recorded as causal organism for a systemic infection.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`87070`	Culture, other source, bacterial; with isolation and presumptive identification of isolates	Performed when blood culture yields organisms requiring growth-based confirmation in addition to molecular identification.

87899 | Unlisted infectious disease microbiology procedure | Used when a specific proprietary assay lacks an exact CPT entry in some billing systems (though 0140U is the PLA code for this test).

87077 | Culture, blood, bacterial isolation and presumptive identification | Blood culture processing codes performed in the microbiology lab prior to or alongside molecular panels.

0000U is not provided in input and must not be added | Data not applicable | Data not applicable

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Professional component	Use when a separate entity reports professional interpretation or reporting (rare for automated PLA tests) alongside technical reporting.
52	Reduced services	Use when test was performed but results limited due to specimen quality, partial run, or instrument failure leading to a reduced-scope report.
53	Discontinued procedure	Use when testing was started but discontinued for clinical or technical reasons prior to completion.
78	Return to the operating room (not typically applicable)	Generally not applicable for this laboratory test; retained in modifier list but used rarely in lab context.
82	Assistant surgeon (unrelated)	Not applicable to laboratory testing but included in the original modifier list.

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RG0100X	Infectious Disease Physician	Clinicians who interpret results to direct antifungal therapy and stewardship.
207L00000X	Clinical Pathology	Pathologists who oversee laboratory testing and result validation.
163W00000X	Critical Care Medicine	Critical care providers who order rapid fungal diagnostics for septic patients.
207P00000X	Emergency Medicine Physician	An emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
282NC2000X	Children's Hospital	Hospitals · General Acute Care Hospital
1835E0208X	Emergency Medicine Pharmacist	A licensed pharmacist who has demonstrated specialized knowledge and skill in the care for patients at the bedside in emergency medicine settings.
246ZS0410X	Surgical Technologist	Surgical technologists are allied health professionals, who are an integral part of the team of medical practitioners providing surgical care to patie…
207RP1002X	Physician Nutrition Specialist (Internal Medicine)	A physician who specializes in the diagnosis and treatment of primary nutritional diseases (e.g., undernutrition, overnutrition, and genetic or acquir…

CPT 0001U: PreciseType HEA Multiplex Erythrocyte Antigen Assay

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: Urine Metabolomic Polyp Risk Assay (PolypDX™)

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa™ (OVA1 Next Generation) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) Urine Gene Expression Risk Test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen with DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Panel, Gene Sequence Analysis

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Cordant CORE™ Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcript Testing

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 0140U: ePlex BCID Fungal Pathogens Panel, Rapid Molecular Detection

Sign up for cpt 0140U policy alerts

Billing Code Overview

OpenPayer

CPT 0140U: ePlex BCID Fungal Pathogens Panel, Rapid Molecular Detection

Sign up for cpt 0140U policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

CPT 0140U: ePlex BCID Fungal Pathogens Panel, Rapid Molecular Detection

Sign up for cpt 0140U policy alerts

Billing Code Overview

CPT 0140U: ePlex BCID Fungal Pathogens Panel, Rapid Molecular Detection

Sign up for cpt 0140U policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT 0140U represent?

Where and how is the ePlex BCID Fungal Pathogens Panel typically performed?

What other CPT codes are commonly associated with or performed alongside 0140U?

Which billing modifiers are applicable to 0140U and are there any modifiers that must not be used?

In what clinical situations is 0140U typically ordered and what diagnoses relate to its use?

References

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT 0140U represent?

Where and how is the ePlex BCID Fungal Pathogens Panel typically performed?

What other CPT codes are commonly associated with or performed alongside 0140U?

Which billing modifiers are applicable to 0140U and are there any modifiers that must not be used?

In what clinical situations is 0140U typically ordered and what diagnoses relate to its use?

References