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    OpenPayerBilling CodesProprietary Laboratory AnalysesCPT cpt-0118u-viracor-trac-donor-derived-cell-free-dna-assay
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    CPT 0118U: Donor‑Derived Cell‑Free DNA Assay for Transplant Monitoring

    CPT code 0118U is a Proprietary Laboratory Analyses (PLA) code for the Viracor TRAC™ donor‑derived cell‑free DNA (dd‑cfDNA) assay, a next‑generation sequencing blood test that quantifies the percentage of donor‑derived cell‑free DNA to monitor allograft injury and transplant rejection after solid organ transplantation; service type: laboratory molecular diagnostic assay performed on patient blood specimens; typical site of service: outpatient laboratory or clinical laboratory associated with transplant programs.

    For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency, Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policy.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old male recipient of a deceased-donor kidney transplant presents for routine post-transplant surveillance. The patient is 6 months post-transplant, on maintenance immunosuppression, and is asymptomatic with stable serum creatinine but the transplant team orders a donor-derived cell-free DNA test to screen for subclinical allograft injury and early rejection. A peripheral blood sample is collected in the clinic or outpatient phlebotomy unit and sent to Viracor Eurofins for the Viracor TRAC™ dd-cfDNA assay. The laboratory performs next-generation sequencing to quantify the percentage of donor-derived cfDNA; results are returned to the transplant nephrology team to aid interpretation alongside clinical data, labs, and, when indicated, biopsy results. Typical site of service is outpatient transplant clinic, hospital outpatient lab, or contracted reference laboratory; service type is Proprietary Laboratory Analyses (PLA) — specialized molecular diagnostic testing.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    0118UViracor TRAC™ donor-derived cell-free DNA (dd-cfDNA) assay, quantification by next-generation sequencingPrimary PLA code for this specific proprietary dd-cfDNA test performed by Viracor Eurofins
    36415Collection of venous blood by venipuncturePerformed immediately prior to sending the sample to the reference lab for dd-cfDNA testing when collection occurs in clinic or outpatient phlebotomy
    85610Prothrombin time; single testExample of routine coagulation monitoring that may be ordered concurrently in transplant follow-up (ancillary test)
    87491Infectious agent detection by nucleic acid (e.g., CMV PCR), quantitative, each organismRepresentative molecular diagnostic test often ordered in transplant recipients alongside dd-cfDNA for infection surveillance
    88305Level IV surgical pathology, gross and microscopic examinationRenal allograft biopsy interpretation code used when dd-cfDNA results prompt a confirmatory graft biopsy

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    P1Modifier P1 indicates an ASA Physical Status I — a normal healthy patient — and is appended to anesthesia CPT codes (00100–01999) based on the anesthesiologist’s clinical assessment. It documents the…- When to apply: Use modifier P1 on anesthesia CPT codes (00100–01999) when the anesthesia provider assigns ASA Physical Status I — a normal healthy patient (non‑smoker, minimal or no alcohol use).…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    207RG0300X
    207V00000X
    363L00000X
    133V00000X
    282NC2000X
    174V00000X
    261QX0100X

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    D47.3Essential (hemorrhagic) thrombocythemia
    D64.9Anemia, unspecified
    E10.9Type 1 diabetes mellitus without complications
    E11.9Type 2 diabetes mellitus without complications
    E78.5Hyperlipidemia, unspecified
    I12.9Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
    I50.9Heart failure, unspecified
    J84.10Pulmonary fibrosis, unspecified

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Carrier Testing Panels for Genetic Diseases (for Kentucky Only)UnitedHealthcare2026-10-01
    Genetic Testing for Neurological Disorders (for Kansas Only)UnitedHealthcare2026-10-01
    Genetic and Molecular TestingProvidence Health Plan2026-10-01
    Cell-Free Fetal DNA Testing (for Idaho Only)UnitedHealthcare2026-10-01
    Next Generation Sequencing for Minimal Residual Disease DetectionProvidence Health Plan2026-10-01
    Pharmacogenetic Panel Testing (for Kansas Only)UnitedHealthcare2026-10-01
    Non-Covered Genetic Panel TestsProvidence Health Plan2026-10-01

    Related Codes

    CPT-0001U-PRECISETYPE-HEA-MULTIPLEX-RBC-ANTIGEN-GENOTYPING

    CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

    CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

    CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

    CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

    CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

    CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

    CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

    CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

    CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

    CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

    CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

    CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

    CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

    CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

    CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

    CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

    CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

    CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

    CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

    Showing 1–10 of 536

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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