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    v1.0.28
    OpenPayerBilling CodesProprietary Laboratory AnalysesCPT cpt-0109u-mycodart-pcr-aspergillus-panel
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    CPT 0109U: MycoDART–PCR Aspergillus Diagnostic Panel

    CPT code 0109U is a Proprietary Laboratory Analyses (PLA) code for the MycoDART–PCR™ Aspergillus diagnostic panel, a dual amplification real‑time PCR test that detects presence or absence of four Aspergillus species in blood, bronchoalveolar lavage fluid, or tissue; service type: molecular infectious disease testing, typical site of service: clinical laboratory or hospital laboratory processing respiratory or tissue specimens.

    For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, B-Hemolytic Streptococcus Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A 56-year-old immunocompromised patient with a history of hematologic malignancy presents with progressive fever, cough, dyspnea, and new focal pulmonary infiltrates on chest imaging. An intensivist and infectious disease physician evaluate the patient in the inpatient setting. Bronchoalveolar lavage (BAL) fluid is obtained during bronchoscopy and submitted to the hospital clinical laboratory for fungal testing. The laboratory performs the MycoDART–PCR™ Aspergillus diagnostic panel, a dual amplification real–time PCR assay that detects four clinically relevant Aspergillus species from blood, BAL fluid, or tissue. Results are reported as presence/absence of Aspergillus DNA to guide antimicrobial selection and infection control decisions. Typical sites of service include the hospital inpatient laboratory, hospital outpatient laboratory or reference laboratory, and the procedure (bronchoscopy) may occur in the operating room, bronchoscopy suite, or intensive care unit. The clinical workflow includes specimen collection (blood/BAL/tissue), specimen accessioning, PCR testing under the laboratory’s PLA test protocol, result validation by laboratory personnel, and result delivery to the treating team for correlation with clinical and radiographic findings.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    0109UMycoDART–PCR™ Aspergillus diagnostic panel; dual amplification real-time PCR for four Aspergillus species (proprietary PLA)Primary laboratory test code for detection of Aspergillus DNA in blood, lavage fluid, or tissue.
    31622Bronchoscopy, flexible, including collection of specimen(s) by brushing or washing or protected brush, with or without fluoroscopic guidanceCommon procedure to obtain BAL or bronchial washings for submission to the laboratory for 0109U testing.
    87471Infectious agent detection by nucleic acid (DNA or RNA); direct probe technique, each organismRelated molecular diagnostic family code representing respiratory pathogen nucleic acid testing methodologies; shown for context when additional molecular testing is performed.
    87899Unlisted microbiology procedureUsed when another specific microbiology/molecular diagnostic procedure is performed that does not have an existing CPT code alongside 0109U in the workflow.
    99223Initial hospital care, typically 70 minutes or moreRepresents inpatient evaluation by the admitting physician for a severely ill patient whose management may include 0109U testing as part of diagnostic workup.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    3416S0300XWater AmbulanceTransportation Services · Ambulance
    207ZC0500XCytopathology PhysicianA cytopathologist is an anatomic pathologist trained in the diagnosis of human disease by means of the study of cells obtained from body secretions an…
    261QX0203XRadiation Oncology Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    261QM0855XAdolescent and Children Mental Health Clinic/CenterAn entity, facility, or distinct part of a facility providing diagnostic, treatment, and prescriptive services related to mental and behavioral disord…
    2085R0205XRadiological Physics PhysicianA radiological physicist deals with the diagnostic and therapeutic applications of roentgen rays, gamma rays from sealed sources, ultrasonic radiation…

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    B20Human immunodeficiency virus [HIV] disease
    B37.7Candidal sepsis
    B44.0Invasive pulmonary aspergillosis
    B44.1Other pulmonary aspergillosis
    B44.2Tonsillar aspergillosis
    B44.7Disseminated aspergillosis
    B44.89Other forms of aspergillosis
    B44.9Aspergillosis, unspecified
    B59Pneumocystosis

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    2 rows

    PolicyPayerEffective Date
    RTM Testing of Homocysteine Metabolism-Related ConditionsOscar Health2026-10-01
    Multimarker Serum Testing Related to Ovarian CancerBlue Cross Blue Shield - Rhode Island2026-09-01

    Related Codes

    CPT-0001U-PRECISETYPE-HEA-MULTIPLEX-RBC-ANTIGEN-GENOTYPING

    CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

    CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

    CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

    CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

    CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

    CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

    CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

    CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

    CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

    CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

    CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

    CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

    CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

    CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

    CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

    CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

    CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

    CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

    CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

    Showing 1–10 of 536

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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